Jurnale medicale
2010

Jurnale medicale 2010

30 Decembrie 2010 22:00
30 Decembrie 2010 22:00
30 Decembrie 2010 22:00

Abstract

Leprosy is an important health problem in Brazil despite extensive use of multidrug therapy. Nasal mucosa is the preferential site of entry and exit of Mycobacterium leprae, and although lesions have been found in oral mucosa, its potential involvement in transmission of leprosy bacilli has

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Clinical Microbiology and Infection
30 Decembrie 2010 22:00

ABSTRACT

In clinical studies on bacteraemia, the negativity of blood cultures is an important end point to compare the efficacy of different therapeutic regimens. In FAN??? anaerobic blood culture medium (BacT/ALERT system), daptomycin displayed increased MIC against Staphylococcus aureus and improve

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Clinical Microbiology and Infection
30 Decembrie 2010
Background: Adolescents and young adults frequently experience mental disorders, yet tend not to seek help. This systematic review aims to summarise reported barriers and facilitators of help-seeking in young people using both qualitative research from surveys, focus groups, and interviews and quant mai mult
BMC Psychiatry - Latest Articles
29 Decembrie 2010 23:01
29 Decembrie 2010 23:01
29 Decembrie 2010 23:01
29 Decembrie 2010 23:01
Background

The treatment of cancer in patients with comorbidities can be challenging as these individuals are underrepresented in clinical trials. We conducted a systematic review to determine the impact of comorbidity on chemotherapy use, delivery, tolerability, and survival among patients with sol

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Journal of Clinical Oncology Current Issue
29 Decembrie 2010 23:01
29 Decembrie 2010 23:01
29 Decembrie 2010 23:01
29 Decembrie 2010 23:01
29 Decembrie 2010 23:01
29 Decembrie 2010 23:01
29 Decembrie 2010 23:01
29 Decembrie 2010 23:01
Purpose

This study was performed to characterize the impact of obesity on the risk of breast cancer recurrence and death as a result of breast cancer or other causes in relation to adjuvant treatment.

Patients and Methods

Information on body mass index (BMI) at diagnosis was available for 18,967 (3

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Journal of Clinical Oncology Current Issue
29 Decembrie 2010 23:01
Purpose

Functional iron deficiency may impair response to erythropoiesis-stimulating agents (ESAs) in iron-replete patients with chemotherapy-associated anemia (CAA). This study evaluated whether coadministration of parenteral iron improves ESA efficacy in patients with CAA.

Patients and Methods

Th

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Journal of Clinical Oncology Current Issue
29 Decembrie 2010 23:01
29 Decembrie 2010 23:01
Purpose

Preclinical studies have suggested accelerated tumor growth, local invasion, and distant metastasis after withdrawal of treatment with some antiangiogenic agents. To investigate whether discontinuation of bevacizumab treatment is associated with accelerated disease progression or increased m

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Journal of Clinical Oncology Current Issue
29 Decembrie 2010 23:01
29 Decembrie 2010 23:01
Purpose

Sorafenib is a kinase inhibitor targeting Raf and other kinases (ie, vascular endothelial growth factor receptor [VEGFR], platelet-derived growth factor receptor [PDGFR], Flt3, and c-KIT). This study assessed its activity and tolerability in patients with recurrent ovarian cancer (OC) or pri

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Journal of Clinical Oncology Current Issue
29 Decembrie 2010 23:01
29 Decembrie 2010 23:01
Purpose

Self-reported diabetes has been associated with poor breast cancer outcomes. Research is needed to investigate the relationship between biologically determined glycemic control and breast cancer prognosis.

Methods

Archived baseline blood samples from the Women's Healthy Eating and Living St

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Journal of Clinical Oncology Current Issue
29 Decembrie 2010 23:01
Purpose

This study aims to develop a robust gene expression classifier that can predict disease relapse in patients with early-stage colorectal cancer (CRC).

Patients and Methods

Fresh frozen tumor tissue from 188 patients with stage I to IV CRC undergoing surgery was analyzed using Agilent 44K oli

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Journal of Clinical Oncology Current Issue
29 Decembrie 2010 23:01
Purpose

The goal of this study was to perform a systematic review and meta-analysis to examine the effect of pre-existing diabetes on breast cancer–related outcomes.

Methods

We searched EMBASE and MEDLINE databases from inception through July 1, 2009, using search terms related to diabetes mellitus

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Journal of Clinical Oncology Current Issue
29 Decembrie 2010 23:01
Purpose

Evaluation of the communication and informed consent process in phase I clinical trial interviews to provide authentic, practice-based content for inclusion in a communication skills training intervention for health care professionals.

Patients and Methods

Seventeen oncologists and 52 patie

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Journal of Clinical Oncology Current Issue
29 Decembrie 2010 23:01
Purpose

To examine the association between serum C-peptide, a marker of insulin secretion, measured 3 years after a breast cancer diagnosis, and death resulting from all causes and breast cancer.

Patients and Methods

This was a prospective, observational study of 604 women enrolled onto the Health,

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Journal of Clinical Oncology Current Issue
29 Decembrie 2010 23:01
Purpose

To use published literature to estimate large, medium, and small differences in quality of life (QOL) data from the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30).

Methods

An innovative method combining systematic review

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Journal of Clinical Oncology Current Issue
29 Decembrie 2010 23:01
Purpose

The National Surgical Adjuvant Breast and Bowel Project C-08 trial was designed to investigate the safety and efficacy of adding bevacizumab to modified FOLFOX6 (mFOLFOX6; ie, infusional/bolus fluorouracil, leucovorin, and oxaliplatin) for the adjuvant treatment of patients with stages II to

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Journal of Clinical Oncology Current Issue
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