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Jurnale medicale
The Journal of Pathology
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Jurnale medicale The Journal of Pathology

30 Ianuarie 2015 07:25

Abstract

ATP7A is a copper transporting P-type ATPase that is essential for cellular copper homeostasis. Loss-of-function mutations in the ATP7A gene result in Menkes disease, a fatal neurodegenerative disorder resulting in seizures, hypotonia, and failure to thrive due to systemic copper deficiency

mai mult
The Journal of Pathology
30 Ianuarie 2015 08:03

Abstract

Peripheral chondrosarcoma (PCS) develops as malignant transformation of an osteochondroma, a benign cartilaginous outgrowth at the bone surface. Its invasive, lobular growth despite low-grade histology suggests a loss of chondrocyte polarity. The known genetics of osteochondromagenesis incl

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The Journal of Pathology
6 Ianuarie 2015 08:17

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a nearly lethal neoplasm. It is a remarkably stroma-rich, vascular-poor and hypo-perfused tumor, which prevents efficient drug delivery. Paradoxically, the neoplastic cells have robust glucose uptake, suggesting the microvasculature has adopted an

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The Journal of Pathology
7 Ianuarie 2015 09:06

Abstract

CaMKIIδ, a calcium/calmodulin-dependent protein kinase, plays pivotal roles in the development of heart disease. In this issue of the Journal of Pathology, Salma Awad and colleagues demonstrate that CaMKIIδ is engaged in both pathological hypertrophy and heart failure. By analysis of mice

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The Journal of Pathology
14 Ianuarie 2015 06:47

Abstract

In diabetic nephropathy (DN), podocyte cytoskeletal rearrangement occurs followed by podocyte effacement and the development of proteinuria. PTEN (phosphatase and tensin homolog) is a ubiquitously expressed phosphatase that plays a critical role in cell proliferation, cytoskeletal rearrange

mai mult
The Journal of Pathology
16 Ianuarie 2015 12:49

Abstract

Melanoma is the leading cause of skin cancer mortality. The major cause of melanoma mortality is metastasis to distant organs, frequently to the brain. The microenvironment plays a critical role in tumorigenesis and metastasis. In order to treat or prevent metastasis, the interactions of di

mai mult
The Journal of Pathology
2 Ianuarie 2015 06:41

Abstract

Oncogene-induced senescence is an important tumour-suppressing mechanism to prevent both premalignant transformation and cancer progression. Overcoming this process is a critical step in early cancer development. The druggable orphan nuclear receptor TLX (NR2E1) is characterized as an impor

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The Journal of Pathology
30 Decembrie 2014 07:38

Abstract

Chronic ethanol consumption causes hepatic steatosis and inflammation, which are associated with liver hypoxia. Monocyte chemoattractant protein-1 (MCP-1) is a hypoxia response factor that determines recruitment and activation of monocytes to the site of tissue injury. The level of MCP-1 is

mai mult
The Journal of Pathology
26 Decembrie 2014 11:32

Abstract

Phaeochromocytomas (PCC) and paragangliomas (PGL) are rare neural crest derived tumours originating from adrenal chomaffin cells or extra-adrenal sympathetic and parasympathetic tissues. More than a third of PCC/PGL cases are associated with heritable syndromes involving thirteen or more kn

mai mult
The Journal of Pathology
24 Decembrie 2014 07:09

Abstract

Our recent work has indicated that the DMP1 locus on 7q21, encoding a haplo-insufficient tumour suppressor, is hemizygously deleted at a high frequency in breast cancer. The locus encodes DMP1? protein, an activator of the p53 pathway leading to cell cycle arrest and senescence, and other

mai mult
The Journal of Pathology
17 Decembrie 2014 12:12

Abstract

The epidermal growth factor receptor (EGFR) is implicated in many types of cancer, including colorectal cancer (CRC), and has become one of the most common candidates for targeted therapy. Here, we found that Erbin, a member of the leucine-rich repeat and PDZ domain (LAP) family, plays a ke

mai mult
The Journal of Pathology
16 Decembrie 2014 07:43

Abstract

Integrins play an important role in vascular biology. The ?8 integrin chain attenuates smooth muscle cell migration but its functional role in the development of atherosclerosis is unclear. Therefore, we studied the contribution of ?8 integrin to atherosclerosis and vascular remodelling.

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The Journal of Pathology
15 Decembrie 2014 07:06

Abstract

Inherited syndromes provide unique opportunities to identify key regulatory mechanisms governing human disease. We previously identified germline loss-of-function DICER1 mutations in a human syndrome defined by the childhood lung neoplasm, pleuropulmonary blastoma (PPB), which arises during

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The Journal of Pathology
11 Decembrie 2014 11:17
10 Decembrie 2014 15:33
10 Decembrie 2014 15:33
9 Decembrie 2014 11:13
9 Decembrie 2014 11:16

Abstract

Human skin color, i.e. pigmentation, differs widely among individuals as do their responses to various types of ultraviolet radiation (UV) and their risks of skin cancer. In some individuals UV-induced pigmentation persists for months to years in a phenomenon termed long-lasting pigmentatio

mai mult
The Journal of Pathology
8 Decembrie 2014 08:12

Abstract

Human papillomaviruses (HPVs) are a necessary cause of carcinoma of the cervix and other mucosal epithelia. Key events in high-risk HPV (HRHPV)-associated neoplastic progression include persistent infection, deregulated expression of virus early genes in basal epithelial cells and genomic i

mai mult
The Journal of Pathology
3 Decembrie 2014 06:41

Abstract

Increasing evidence supports the association of catenin delta-1 (CTNND1, p120ctn) with tumor development and progression. However, the mechanism and clinical significance of CTNND1 deregulation in gastric cancer remain unknown. The expression level and cellular localization of CTNND1 were d

mai mult
The Journal of Pathology
3 Decembrie 2014 06:42

Abstract

Breast cancer survival rates decrease from 99% for patients with local disease to 25% for those with distant metastases. Matrix metalloproteinases (MMPs), including MMP2, are associated with metastatic progression. We found that loss of host MMP2 reduces the proliferation of experimental me

mai mult
The Journal of Pathology
28 Noiembrie 2014 05:27

Abstract

Although many pre-clinical studies have implicated ?3 integrin receptors (?v?3 and ?IIb?3) in cancer progression, ?3 inhibitors have shown only modest efficacy in patients with advanced solid tumours. The limited efficacy of ?3 inhibitors in patients could arise from our incomplete u

mai mult
The Journal of Pathology
28 Noiembrie 2014 07:13

Abstract

Activation of Wnt/?-catenin signaling is frequently observed in many types of cancers including hepatocellular carcinoma (HCC). We recently reported that Cullin 4B (CUL4B), a scaffold protein that assembles CRL4B ubiquitin ligase complexes, is overexpressed in many types of solid tumors an

mai mult
The Journal of Pathology
28 Noiembrie 2014 07:13

Abstract

Amyloid ? peptide (A?) immunization of Alzheimer's disease (AD) patients has been reported to induce amyloid plaque removal but with little impact on cognitive decline. We have explored the consequences of A? immunotherapy on neurons in post-mortem brain tissue. Eleven immunized (AN1792,

mai mult
The Journal of Pathology
26 Noiembrie 2014 06:38

Abstract

Mutations in genes encoding proteins involved in RNA splicing have been found to occur at relatively high frequencies in several tumour types including myelodysplastic syndromes, chronic lymphocytic leukaemia, uveal melanoma, pancreatic cancer and at lower frequencies in breast cancer. To i

mai mult
The Journal of Pathology
25 Noiembrie 2014 08:42

Abstract

Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are the most frequently occurring histological subtypes of breast cancer, accounting for 80??90% and 10??15% of the total cases, respectively. At time of diagnosis and surgical resection of the primary tumour, most patie

mai mult
The Journal of Pathology
25 Noiembrie 2014 08:44

Abstract

Heart failure is associated with the reactivation of a fetal cardiac gene program which has become a hallmark of cardiac hypertrophy and maladaptive ventricular remodeling. Yet the mechanisms that regulate this transcriptional reprogramming are not fully understood. Using mice with genetic

mai mult
The Journal of Pathology
25 Noiembrie 2014 08:45

Abstract

Macrophages play a central role in immune and tissue responses of granulomatous lung diseases induced by pathogens and foreign bodies. Circulating monocytes are generally viewed as central precursors of these tissue effector macrophages. Here, we provide evidence that granulomas derive from

mai mult
The Journal of Pathology
21 Noiembrie 2014 06:40

Abstract

Fibroblast growth factor (FGF) 9 is essential for lung development and is highly expressed in a subset of human lung adenocarcinomas. We recently described a mouse model in which FGF9 expression in the lung epithelium caused proliferation of the airway epithelium at the terminal bronchioles

mai mult
The Journal of Pathology
19 Noiembrie 2014 07:01

Abstract

Idiopathic Focal Segmental Glomerulosclerosis (FSGS) is a progressive and proteinuric kidney disease that starts with podocyte injury. Podocytes cover the external side of the glomerular capillary by a complex web of primary and secondary ramifications. Similar to dendritic spines of neuron

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The Journal of Pathology
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