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Jurnale medicale
Alergologie si imunologie clinica

Jurnale medicale Alergologie si imunologie clinica

7 Februarie 2015 14:16

Abstract

Background

Interleukin 33 (IL-33) is implicated as an epithelium-derived danger signal promoting Th2-dependent responses in asthma. We hypothesized that IL-33 might also have direct effects on mast cell-driven allergic airway obstruction.

Methods

The effects of IL-33 on allergic responses in

mai mult
Allergy
4 Februarie 2015 14:52

Abstract

Background

Currently there is no mandatory labelling of allergens for non-pre-packed foods in the EU. Therefore, consumers with food allergy rely on voluntary information provided by the staff. The aim of this study was to characterise allergic reactions to non-pre-packed foods and to invest

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Allergy
29 Ianuarie 2015 06:41

Abstract

The aim of the study was to investigate if adverse drug reactions (ADRs) during immunotherapy with a grass extract (AVANZĀ? Phleum, ALK-Abell??) are related to the different patterns of sensitization of patients to grass allergens.

192 patients with rhinitis and/or asthma sensitized to gras

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Allergy
29 Ianuarie 2015 06:56

Abstract

Background

A detailed characterization of human oral immune cells is needed to better understand local mechanisms associated with allergen capture following oral exposure.

Methods

Oral immune cells were characterized by immunohistology and immunofluorescence in biopsies obtained from 3 health

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Allergy
29 Ianuarie 2015 06:58

Abstract

Background

Chronic sinusitis (CRS) is a common otorhinolaryngologic disease that is frequently encountered in everyday practice, but there is lack of precise data regarding the prevalence of CRS in developing countries. We performed a national investigation in China to determine the prevalen

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Allergy
29 Ianuarie 2015 07:07

Abstract

Background

Identifying inflammatory phenotypes is relevant in severe uncontrolled asthma. The aim of the present study was to identify the different clinical, inflammatory, functional and molecular phenotypes in patients with severe asthma and to investigate the potential role of sputum peri

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Allergy
29 Ianuarie 2015 07:29

Abstract

Chronic spontaneous urticaria (CSU) significantly impacts the quality of life of those affected through symptoms of pruritus and recurrent skin lesions. In active CSU disease, reduced IgE-mediated basophil histamine release (HR) and basopenia are observed. We sought to examine the relations

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Allergy
30 Ianuarie 2015 07:31

Abstract

Background

Recommended management of attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor (C1-INH) deficiency (C1-INH-HAE) includes therapy with exogenous C1INH. Thrombotic/thromboembolic events (TEE) have been reported with plasma-derived C1INH, but so far none with recombina

mai mult
Allergy
30 Ianuarie 2015 07:42

Abstract

Occupational exposure to gas, dust and fumes (GDF) increases the risk of asthma and eczema. We investigated the role of sensitisation in the association between GDF and allergic conditions. A population-based sample of 788 adults from the West Sweden Asthma Study completed questionnaires an

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Allergy
30 Ianuarie 2015 07:43

Abstract

In most of the cases the standard diagnosis of an allergic disease is based on a detailed clinical history and demonstration of sensitisation (either by skin test or in vitro testing) to a relevant allergen concordant with the history. The allergen provocation test is rarely required. Howev

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Allergy
30 Ianuarie 2015 07:57

Abstract

Background

The EuroPrevall project aimed to develop effective management strategies in food allergy through a suite of interconnected studies and a multidisciplinary integrated approach. To address some of the gaps in food allergy diagnosis, allergen risk management and socioeconomic impact,

mai mult
Allergy
3 Februarie 2015 13:40

Abstract

Background

Food allergy, in particular peanut allergy, is a growing concern in Western countries. The prevalence of allergy to peanut, which currently stands at 1.4%, has nearly tripled between 1997 to 2008. Allergic sensitization is a particularly difficult process to study as it is clinica

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Allergy
3 Februarie 2015 15:41

Abstract

Background

Patients with a previous history of hypersensitivity reaction (HSR) to iodinated contrast media (ICM) are at high risk for the development of HSR to ICM. Many studies have tried to evaluate the diagnostic potential of skin tests in this population but have not yet reached a common

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Allergy
28 Ianuarie 2015 07:29

Abstract

Background

An important advantage of allergen immunotherapy as compared to pharmacotherapy for allergic rhinitis is the long-term effect that persists after completing immunotherapy. The mechanism of the sustained effect of allergen immunotherapy is not completely understood.

Methods

We condu

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Allergy
28 Ianuarie 2015 07:30

Abstract

Background

Although food allergy has universally been found to impair HRQL, studies have found significant differences in HRQL between countries, even when corrected for differences in perceived disease severity. However, little is known about factors other than disease severity which may co

mai mult
Allergy
28 Ianuarie 2015 14:28

Abstract

Asthma is a major public health issue. The co-occurrence of the high prevalence of asthma and vitamin D deficiency documented globally in recent decades has prompted several investigations into a possible association between the two conditions. The objective of this paper was to synthesise

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Allergy
8 Ianuarie 2015 13:47

Abstract

Background

Mastocytosis is characterized by clonal proliferation of mast cells limited to the skin (cutaneous mastocytosis: CM and mastocytosis in the skin: MIS) and/or involving internal organs (systemic mastocytosis: SM). Oxidative stress occurring in various inflammatory and neoplastic di

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Allergy
22 Ianuarie 2015 07:04

Abstract

Growing evidence identifies histamine as a key player in allergic responses, but the reports relating serum histamine to tolerance are scarce and inconclusive. This study investigated the relationship of circulating histamine to the tolerant phenotype in allergic beekeepers. The results sho

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Allergy
23 Ianuarie 2015 13:26

Abstract

Background

Antigen-specific human IgEs are important reagents in immunoassays to quantify antigen-specific IgEs in allergic patients, but they are not easy to prepare. .

Methods

We constructed a knock-in homozygous mouse strain, referred to as HĪ?Ī?KI strain, whose gene segment encoding Ī?1 c

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Allergy
24 Ianuarie 2015 06:32

Abstract

Background

We tested the hypothesis that specific molecular sensitization patterns correlate with the clinical data/manifestation in a European peanut allergic population characterized under a common protocol.

Methods

68 peanut allergic subjects and 82 tolerant controls from 11 European count

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Allergy
24 Ianuarie 2015 06:33

Abstract

Rhinitis is an umbrella term that encompasses many different subtypes, several of which still elude complete characterization. The concept of phenotyping, being the definition of disease subtypes on the basis of clinical presentation, has been well established in the last decade. Classifica

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Allergy
26 Ianuarie 2015 07:24

Abstract

Background

Eosinophilic esophagitis (EoE) exhibits esophageal dysfunction owing to an eosinophil-predominant inflammation. Activated eosinophils generate eosinophil extracellular traps (EETs) able to kill bacteria. There is evidence of an impaired barrier function in EoE that might allow pat

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Allergy
26 Ianuarie 2015 09:24

Abstract

The aim of this study was to assess the genetic association of Filaggrin loss-of-function (FLG LOF) genetic variants with food allergy, and to investigate the added value of this test in diagnosing food allergy. Clinical reactivity to foods was diagnosed by the gold standard, the double-bli

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Allergy
26 Ianuarie 2015 09:29

Abstract

Background

Asthma is characterized by chronic airway inflammation and airway hyperresponsiveness (AHR). Little is known about the role of pulmonary stem/progenitor cells (PSCs) in allergic airway inflammation.

Methods

To identify and investigate the role of PSCs in the bronchial epithelium of

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Allergy
3 Ianuarie 2015 06:45

Abstract

Background

Despite the critical role of IgE in allergy, circulating IgE+ B cells are scarce. Here we describe in patients with allergic rhinitis B cells with a memory phenotype responding to a prototypic aeroallergen.

Methods

Fifteen allergic rhinitis patients with grass pollen allergy and 13

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Allergy
3 Ianuarie 2015 06:47

Abstract

Syk, an immune regulatory tyrosine kinase, plays a role in inflammatory disease processes. We recently reported a role for epithelial expression of Syk in the airways hyperresponsiveness in response to air pollution in a mouse model of asthma. The aim of this study was to further investigat

mai mult
Allergy
3 Ianuarie 2015 06:47

Abstract

In the general population, a history of asthma (HA) is associated with a higher risk of mortality of anaphylactic shock (AS), but it is unknown whether this association remains valid for intraoperative AS. The goal of this retrospective study was to investigate whether a HA was associated w

mai mult
Allergy
3 Ianuarie 2015 06:47

Abstract

Background

Interleukin (IL) 37 has been described as negative regulator of innate immunity, since it reduces the activation and cytokine production of different innate immune cells. Recently, results from the CLARA childhood asthma cohort suggested an implication of IL-37 for human asthma pa

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Allergy
15 Decembrie 2014 04:38

Abstract

Background

Patients with asthma may be more susceptible to adverse events (AEs) with sublingual immunotherapy tablet (SLIT-tablet) treatment, such as severe systemic reactions and asthma-related events. Using data from 8 trials of grass SLIT-tablet in subjects with allergic rhinitis with/wit

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Allergy
15 Decembrie 2014 04:56

Abstract

The impact of early childhood Traffic Related Air Pollution (TRAP) exposure on development of asthma and allergies remains unclear. Birth cohort studies are the best available study design to answer this question, but the evidence from such studies has not been synthesised to date. We condu

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Allergy
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