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American Journal of Hematology
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Jurnale medicale American Journal of Hematology

4 Februarie 2015 08:31

Abstract

Mutations in IDH1 and IDH2 occur in 15-20% of AML cases, resulting in the production of 2-hydroxyglutarate, which promotes aberrant hypermethylation of DNA in leukemic cells. Although these mutations have been shown to have prognostic implications for patients with AML, optimal treatment st

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American Journal of Hematology
4 Februarie 2015 21:31

Abstract

Therapy-related myeloid neoplasms (t-MN) are a complication of cytotoxic treatment for primary tumors and autoimmune diseases.

We report data on 277 t-MN patients, recruited between 1999 and 2013 by the Italian Network on Secondary Leukemias (104 retrospectively and 173 prospectively regist

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American Journal of Hematology
4 Februarie 2015 21:31

Abstract

Despite the common practice of combining dexamethasone (Dex) with bortezomib (Bz) in patients with multiple myeloma (MM), until now there has been few prospective trials undertaken. We undertook a trial that recapitulated the original APEX study except that dexamethasone was incorporated fr

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American Journal of Hematology
30 Ianuarie 2015 12:05

ABSTRACT

Many drugs have been reported to cause thrombotic microangiopathy (TMA), often described as thrombotic thrombocytopenic purpura (TTP) or hemolytic-uremic syndrome (HUS). We recently established criteria to evaluate the evidence for a causal association of a drug with TMA and then we systema

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American Journal of Hematology
31 Ianuarie 2015 06:47

Abstract

Among 274 patients with chronic myelomonocytic leukemia (CMML) and followed for a median of 17.1 months, blast transformation (BT) occurred in 36 (13%). On multivariable analysis, risk factors for BT were presence of circulating blasts (HR 5.7; 95% CI 2.8-11.9) and female gender (HR 2.6; 95%

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American Journal of Hematology
31 Ianuarie 2015 06:47
31 Ianuarie 2015 06:47
2 Februarie 2015 21:31

Abstract

The treatment of relapsed/refractory chronic lymphocytic leukemia (CLL) remains a challenging clinical issue. An important treatment option is the use of high-dose corticosteroids. The purpose of this clinical trial was to determine the efficacy and toxicity of an ofatumumab-dexamethasone (

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American Journal of Hematology
5 Ianuarie 2015 14:02
7 Ianuarie 2015 21:18

Abstract

Pediatric acquired aplastic anemia (AA) is a bone marrow disorder that is difficult to distinguish from inherited bone marrow failure syndrome and hypocellular refractory cytopenia of childhood (RCC). Historically, patients with hypocellular RCC have been given the diagnosis of AA. To asses

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American Journal of Hematology
7 Ianuarie 2015 21:18

Abstract

Bortezomib and lenalidomide are increasingly used in patients with AL amyloidosis, but long term data on their use as primary therapy in AL amyloidosis are lacking while early mortality remains significant. Thus, we analyzed the long term outcomes of 85 consecutive unselected patients, whic

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American Journal of Hematology
7 Ianuarie 2015 21:20

Abstract

Rare but serious cardiovascular and pulmonary adverse events (AEs) have been reported in patients with chronic myeloid leukemia treated with BCR-ABL inhibitors. Clinical trial data may not reflect the full AE profile of BCR-ABL inhibitors because of stringent study entry criteria, relativel

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American Journal of Hematology
7 Ianuarie 2015 21:20

Abstract

Anti-HLA antibodies can adversely impact the care of hematology patients. In particular, HLA antibody testing provides important information for optimal stem cell and platelet donor selection in the management of stem cell recipients and platelet refractory patients. Current testing methods

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American Journal of Hematology
10 Ianuarie 2015 06:17

Abstract

Although transformation to Hodgkin lymphoma (HL) is a recognized complication in patients with chronic lymphocytic leukemia (CLL), its incidence, clinical characteristics and outcomes are not well defined.We used the Mayo Clinic CLL and Lymphoma Databases to identify CLL patients who develo

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American Journal of Hematology
10 Ianuarie 2015 06:18
12 Ianuarie 2015 07:10

Abstract

Red blood cells (RBCs) are deformable and flow through vessels narrower than their own size. Their deformability is most stringently challenged when they cross micrometer-wide slits in the spleen. In several inherited or acquired RBC disorders, blockade of small vessels by stiff RBCs can tr

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American Journal of Hematology
12 Ianuarie 2015 07:40

Abstract

As life expectancy increases in persons with hemophilia (PWH), more age-related diseases such as cancer emerge among this patient group. The aim of this study was to investigate incidence and survival of cancers among PWH in Taiwan. We analyzed data of 1054 PWH retrieved from Taiwan's Natio

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American Journal of Hematology
12 Ianuarie 2015 07:49
12 Ianuarie 2015 08:08
12 Ianuarie 2015 08:25
12 Ianuarie 2015 08:46

Abstract

Flavopiridol and lenalidomide have activity in refractory CLL without immunosuppression or opportunistic infections seen with other therapies. We hypothesized that flavopiridol treatment could adequately de-bulk disease prior to lenalidomide therapy, decreasing the incidence of tumor flare

mai mult
American Journal of Hematology
21 Ianuarie 2015 18:32

Disease overview: Polycythemia vera (PV) and essential thrombocythemia (ET) are myeloproliferative neoplasms, respectively characterized by erythrocytosis and thrombocytosis. Other disease features include leukocytosis, splenomegaly, thrombosis, bleeding, microcirculatory symptoms, pruritus, and ris

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American Journal of Hematology
21 Ianuarie 2015 23:00
21 Ianuarie 2015 23:01
22 Ianuarie 2015 12:42
22 Ianuarie 2015 13:18
22 Ianuarie 2015 13:41
23 Ianuarie 2015 09:47

ABSTRACT

Genome-wide association studies (GWAS) hold tremendous promise to improve our understanding of human biology. Recent GWAS have revealed over 75 loci associated with erythroid traits, including the 4q27 locus that is associated with red blood cell size (mean corpuscular volume, MCV). The clo

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American Journal of Hematology
23 Ianuarie 2015 09:51
23 Ianuarie 2015 10:10
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