Home Jurnale medicale Anatomie patologica, Chirurgie cardiovasculara
Jurnale medicale
Anatomie patologica
Chirurgie cardiovasculara

Jurnale medicale Anatomie patologica, Chirurgie cardiovasculara

6 Februarie 2015 21:05
6 Februarie 2015 21:05
6 Februarie 2015 21:05
Background—

The contemporary practice patterns and role of catheter-directed thrombolysis (CDT) in the treatment of inferior vena cava thrombosis is unknown.

Methods and Results—

The Nationwide Inpatient Sample database was used to identify patients with a principal discharge diagnosis of inferior

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Circulation: Cardiovascular Interventions current issue
5 Februarie 2015 21:00
Background—

Eptifibatide, a small-molecule glycoprotein IIb/IIIa inhibitor, is conventionally administered as a bolus plus infusion. A growing number of clinicians are using a strategy of catheterization laboratory–only eptifibatide (an off-label use) as procedural pharmacotherapy for patients under

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Circulation: Cardiovascular Interventions current issue
5 Februarie 2015 21:00
Background—

Up to 1 in 6 patients undergoing transcatheter aortic valve implantation (TAVI) present with low-ejection fraction, low-gradient (LEF-LG) severe aortic stenosis and concomitant relevant mitral regurgitation (MR) is present in 30% to 55% of these patients. The effect of MR on clinical out

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Circulation: Cardiovascular Interventions current issue
5 Februarie 2015 21:00
5 Februarie 2015 21:00
5 Februarie 2015 21:00
4 Februarie 2015 21:00
Background—

Percutaneous pulmonary valve implantation (PPVI) is a safe, less invasive alternative to surgical valve replacement for the congenital heart disease patient with right ventricular (RV) outflow tract dysfunction. The aim of this study was to determine whether reverse RV remodeling after P

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Circulation: Cardiovascular Interventions current issue
4 Februarie 2015 21:00
Background—

There is a conflicting evidence on safety and efficacy of transcatheter aortic valve implantation in patients with preoperative chronic kidney disease (CKD). Therefore, we conducted a meta-analysis on the impact of CKD on outcomes after transcatheter aortic valve implantation.

Methods a mai mult
Circulation: Cardiovascular Interventions current issue
4 Februarie 2015 21:00
4 Februarie 2015 21:00
Background—

The pathology of radiofrequency-derived sympathetic renal denervation has not been studied over time and may provide important understanding of the mechanisms resulting in sustained blood pressure reduction. The purpose of this study was to investigate chronological changes after radiofr

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Circulation: Cardiovascular Interventions current issue
5 Februarie 2015 17:00

Immunotherapy of B-cell malignancies using CD19-targeted chimeric antigen receptor–transduced T cells or CD20-targeted therapeutic monoclonal antibodies has shown clinical efficacy. However, refractory disease and the emergence of antigen-loss tumor escape variants after treatment demonstrate the ne

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Blood current issue
5 Februarie 2015 17:00
5 Februarie 2015 17:00

Thrombopoietin (Thpo) signaling through the c-Mpl receptor promotes either quiescence or proliferation of hematopoietic stem cells (HSCs) in a concentration-dependent manner; however, in vivo Thpo serum levels are responsive to platelet mass rather than HSC demands, suggesting additional regulation

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Blood current issue
5 Februarie 2015 17:00
5 Februarie 2015 17:00
5 Februarie 2015 17:00
5 Februarie 2015 17:00
5 Februarie 2015 17:00

Defects of the platelet P2Y12 receptor (P2Y12R) for adenosine diphosphate (ADP) are associated with increased bleeding risk. The study of molecular abnormalities associated with inherited qualitative defects of the P2Y12R protein is useful to unravel structure-function relationships of the receptor.

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Blood current issue
5 Februarie 2015 17:00

Vascular safety is an emerging issue in patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors (TKIs). Whereas imatinib exhibits a well-documented and favorable long-term safety profile without obvious accumulation of vascular events, several types of vascular adverse e

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Blood current issue
5 Februarie 2015 17:00

Serum cytokines and chemokines may reflect tumor biology and host response in follicular lymphoma (FL). To determine whether the addition of these biological factors may further refine prognostication, 30 cytokines and chemokines were measured in pretreatment serum specimens from newly diagnosed FL

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Blood current issue
5 Februarie 2015 17:00
5 Februarie 2015 17:00

Translocation of the mixed-lineage leukemia (MLL) gene with AF4, AF9, or ENL results in acute leukemia with both lymphoid and myeloid involvement. We characterized leukemia-initiating cells (LICs) in primary infant MLL-rearranged leukemia using a xenotransplantation model. In MLL-AF4 patients, CD34+

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Blood current issue
5 Februarie 2015 17:00

To explore how RUNX1 mutations predispose to leukemia, we generated induced pluripotent stem cells (iPSCs) from 2 pedigrees with germline RUNX1 mutations. The first, carrying a missense R174Q mutation, which acts as a dominant-negative mutant, is associated with thrombocytopenia and leukemia, and th

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Blood current issue
5 Februarie 2015 17:00

Current guidelines for heparin-induced thrombocytopenia (HIT) management recommend heparin cessation and switching to a nonheparin anticoagulant (ie, argatroban, danaparoid) upon clinical suspicion. Fondaparinux may be effective but information supporting its use is limited. We retrospectively evalu

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Blood current issue
5 Februarie 2015 17:00

Non-Hodgkin lymphomas (NHLs) are the most common cancer to affect pet dogs. In contrast to the many genes whose mutation contributes to lymphomagenesis in humans, relatively little is known about the acquired genetic alterations that lead to canine B-cell lymphomas (cBCLs). We performed a survey of

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Blood current issue
5 Februarie 2015 17:00

The Therapeutic Intensification in De Novo Leukaemia (TIDEL)-II study enrolled 210 patients with chronic phase chronic myeloid leukemia (CML) in two equal, sequential cohorts. All started treatment with imatinib 600 mg/day. Imatinib plasma trough level was performed at day 22 and if <1000 ng/mL, ima

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Blood current issue
5 Februarie 2015 17:00

Effective treatment of diffuse large B-cell lymphoma (DLBCL) is plagued by heterogeneous responses to standard therapy, and molecular mechanisms underlying unfavorable outcomes in lymphoma patients remain elusive. Here, we profiled 148 genomes with 91 matching transcriptomes in a DLBCL cohort treate

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Blood current issue
5 Februarie 2015 17:00

Type 2 von Willebrand disease (VWD) includes a wide range of qualitative abnormalities of von Willebrand factor structure and function resulting in a variable bleeding tendency. According to the current classification, 4 different subtypes can be identified, each with distinctive phenotypic and ther

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Blood current issue
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