Home Jurnale medicale Anatomie patologica, Endocrinologie
Jurnale medicale
Anatomie patologica
Endocrinologie

Jurnale medicale Anatomie patologica, Endocrinologie

6 Februarie 2015 11:54
Objective

The effects of vitamin D in the elderly are inconsistent. The aim of this study was to evaluate the association between vitamin D status and the metabolic syndrome (MetS) in the elderly, as well as between vitamin D status and the components of MetS (i.e. serum glucose, triglycerides (TG),

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Background

Reports conflict concerning measurements of plasma metanephrines (MNs) for diagnosis of pheochromocytomas/paragangliomas (PPGLs) by immunoassays compared with other methods. We aimed to compare the performance of a commercially available enzyme-linked immunoassay (EIA) kit with liquid chr

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

Management of insulinomas in the context of MEN1 remains poorly studied. The aim of this study was to evaluate long-term results of various surgical approaches in a large cohort of insulinoma–MEN1 patients.

Design and methods

Consecutive insulinoma–MEN1 patients operated on for a nonmetas

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Context and objective

Patients with cranial diabetes insipidus (CDI) are at risk of developing both hypernatraemia and hyponatraemia, due to the condition itself or secondary to treatment with vasopressin-analogues or during administration of i.v. fluids. We aimed to assess the frequency and impact

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

MicroRNAs (miRNAs) are involved in the regulation of adiposity, but functional studies have yielded inconclusive results. Examining the associations of circulating miRNAs levels with obesity and insulin sensitivity in humans may lead to improved insights.

Design and methods

Serum samples

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

The objective was to assess the amount of vitamin D3 stored in adipose tissue after long-term supplementation with high dose vitamin D3.

Design

A cross-sectional study on 29 subjects with impaired glucose tolerance who had participated in a randomized controlled trial with vitamin D3 20 0

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

Mutations in the glucokinase (GCK) gene, along with hepatocyte nuclear factor 1A (HNF1A) gene mutations, are the most frequent cause of maturity-onset diabetes of the young (MODY). GCK-MODY patients are typically characterized by a moderate fasting hyperglycemia; however, little is known ab

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

To assess whether single nucleotide polymorphisms of HSD17B5 (AKR1C3) (rs1937845 and rs12529) and HSD17B6 (rs898611) are associated with polycystic ovary syndrome (PCOS) in a Chinese population.

Design

A case–control study was conducted to investigate the relation between HSD17B5 and HSD1

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

Germany was iodine deficient until the mid-1990s when a nationwide iodine fortification program became effective. It is expected that after a longer period of sufficient iodine supply, median TSH values in the general population will shift to the right. Hence, the previous TSH reference ra

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54

Mineralocorticoid receptor antagonists have been used in patients with aldosterone-producing adenomas (APAs) as a test designed to predict the blood pressure (BP) outcome of surgery. They are commonly used in patients undergoing adrenalectomy to reduce BP and increase plasma potassium levels during

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

There are scarce reports regarding the prognosis of a second course of antithyroid drug (ATD) therapy on recurrent Graves' disease (GD). The aim of this study was to assess the long-term remission rate after a second ATD therapy and verify significant clinical predictors of a remission.

D mai mult
European Journal of Endocrinology current issue
6 Februarie 2015 11:54

Adrenal crisis is a life-threatening emergency contributing to the excess mortality of patients with adrenal insufficiency. Studies in patients on chronic replacement therapy for adrenal insufficiency have revealed an incidence of 5–10 adrenal crises/100 patient years and suggested a mortality rate

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

To obtain structured information on the diagnostic delay in patients with Cushing's disease (CD) from the patients perspective to provide leverage points for earlier diagnosis.

Design

The study includes 176 patients with ACTH-dependent CD who had received pituitary surgery completed a sel

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

Diabetes mellitus (DM) is associated with endothelial dysfunction, reducing nitric oxide-dependent vasodilation, and increasing production of pro-inflammatory factors, leading to an increased risk of long-term cardiovascular disease. As the effects of phosphodiesterase 5 inhibitors (PDE5i)

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54

Recently, an increased incidence of central diabetes insipidus (CDI) in pregnancy, and less frequently in the post partum period, has been reported, most probably favoured by some conditions occurring in pregnancy. This study was aimed at investigating the influence of pregnancy on a pre-existing po

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

To review the published literature on the effects of telecare intervention in patients with type 2 diabetes and inadequate glycemic control.

Design and methods

A review of randomized controlled trials on telecare intervention in patients with type 2 diabetes, and a search of electronic da

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

Intravenous glucocorticoid (i.v.GC) pulse therapy for Graves' ophthalmopathy (GO) can be associated with acute liver damage (ALD), which was roughly estimated to occur in ~1% of patients, with an overall mortality of 0.4%. The aim of this study was to evaluate the frequency of ALD after th

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

Specific germline mutations in the RET proto-oncogene are correlated with clinical features in multiple endocrine neoplasia type 2A (MEN2A); however, data are scarce regarding differences in clinical profiles dependent on the type of nucleotide and amino acid substitution at the same codon

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European Journal of Endocrinology current issue
7 Februarie 2015 14:26

Summary

Objective

To investigate the response of serum fibroblast growth factor 21 (FGF21) to a meal and to insulin infusion in haemodialysis (HD) patients.

Design and Patients

Meal study: in a cross-over design, 12 non-diabetic HD patients were randomly assigned to: 1) a non-HD day with one meal serv

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Clinical Endocrinology
7 Februarie 2015 14:26

Abstract

Objectives

Lower circulating androgens and poorer lung function are associated with increased cardiovascular risk and mortality in men. The association between androgens and lung function is unclear. We tested the hypothesis that circulating testosterone (T) and its metabolites dihydrotestos

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Clinical Endocrinology
5 Februarie 2015 14:12

Abstract

Objective

Serum thyroglobulin (Tg) is a marker of residual differentiated thyroid cancer (DTC) after total thyroidectomy, however circulating anti-thyroglobulin antibodies (TgAb) may interfere with the immunoassay for Tg. Ultrasensitive assays may have a more significant role in detecting ci

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Clinical Endocrinology
5 Februarie 2015 17:00

Immunotherapy of B-cell malignancies using CD19-targeted chimeric antigen receptor–transduced T cells or CD20-targeted therapeutic monoclonal antibodies has shown clinical efficacy. However, refractory disease and the emergence of antigen-loss tumor escape variants after treatment demonstrate the ne

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Blood current issue
5 Februarie 2015 17:00
5 Februarie 2015 17:00

Thrombopoietin (Thpo) signaling through the c-Mpl receptor promotes either quiescence or proliferation of hematopoietic stem cells (HSCs) in a concentration-dependent manner; however, in vivo Thpo serum levels are responsive to platelet mass rather than HSC demands, suggesting additional regulation

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Blood current issue
5 Februarie 2015 17:00
5 Februarie 2015 17:00
5 Februarie 2015 17:00
5 Februarie 2015 17:00
5 Februarie 2015 17:00

Defects of the platelet P2Y12 receptor (P2Y12R) for adenosine diphosphate (ADP) are associated with increased bleeding risk. The study of molecular abnormalities associated with inherited qualitative defects of the P2Y12R protein is useful to unravel structure-function relationships of the receptor.

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Blood current issue
5 Februarie 2015 17:00

Vascular safety is an emerging issue in patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors (TKIs). Whereas imatinib exhibits a well-documented and favorable long-term safety profile without obvious accumulation of vascular events, several types of vascular adverse e

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Blood current issue
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