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Jurnale medicale
Anatomie patologica
Psihiatrie

Jurnale medicale Anatomie patologica, Psihiatrie

6 Februarie 2015
Background: Cognitive behavioural therapy (CBT) is recommended for the treatment of depression and anxiety. However, access is limited. Low-intensity approaches such as guided CBT self-help (bibliotherapy) can increase access to treatment and is recommended by UK guidelines. No previous research has mai mult
BMC Psychiatry - Latest Articles
6 Februarie 2015
Background: The main objective of this study was to assess psychiatric morbidity among adolescents following the Omagh car bombing in Northern Ireland in 1998. Methods: Data was collected within schools from adolescents aged between 14 and 18?years via a self-completion booklet comprised of establis mai mult
BMC Psychiatry - Latest Articles
5 Februarie 2015 12:00
Background: Depression is a common mental disorder associated with substantial disability. It is inadequately recognised and managed, and clinicians? attitudes to this condition and its treatment may play a part in this. Most research in this area has used the Depression Attitude Questionnaire (DAQ) mai mult
BMC Psychiatry - Latest Articles
5 Februarie 2015 12:00
Background: Many of the assessment tools used to study depression among older people are adaptations of instruments developed in other cultural setting. There is a need to validate those instruments in low and middle income countries (LMIC) Methods: A one-phase cross-sectional survey of people aged mai mult
BMC Psychiatry - Latest Articles
5 Februarie 2015 12:00
Background: Behavioral disturbances following chemotherapy with cisplatin are rare. Here, we report a patient with temporary loss of moral behavior in the setting of cisplatin-based chemotherapy for treatment of tonsillar cancer.Case presentationA 66-year-old Caucasian male with no psychiatric or vi mai mult
BMC Psychiatry - Latest Articles
5 Februarie 2015 12:00
Background: Suicidal behaviours are major public health concerns worldwide. They are associated with risk factors that vary with age and gender, occur in combination, and may change over time. The aim of our study was to investigate how frequently patients visiting a hospital emergency room (ER) req mai mult
BMC Psychiatry - Latest Articles
5 Februarie 2015 12:00
Background: There is limited knowledge about how environmental factors affect the course of bipolar disorder (BD). Cannabis has been proposed as a potential risk factor for poorer course of illness, but the role of cannabis use has not been studied in a first treatment BD I sample. Methods: The pres mai mult
BMC Psychiatry - Latest Articles
5 Februarie 2015 12:00
Background: Prenatal depression can negatively affect the physical and mental health of both mother and fetus. The aim of this study was to determine the effectiveness of yoga as an intervention in the management of prenatal depression. Methods: A systematic review and meta-analysis of randomized co mai mult
BMC Psychiatry - Latest Articles
5 Februarie 2015 12:00
Background: Although exposure to early life stress is known to affect mental health, the underlying mechanisms of its impacts on depressive symptoms among institutionalized children and adolescents have been little studied. Methods: To investigate the role of attachment and self-esteem in associatio mai mult
BMC Psychiatry - Latest Articles
5 Februarie 2015 12:00
Background: Historically, the focus of Non Communicable Disease (NCD) prevention and control has been cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), cancer and chronic respiratory diseases. Collectively, these account for more deaths than any other NCDs. Despite recent calls to inclu mai mult
BMC Psychiatry - Latest Articles
5 Februarie 2015 12:00
Background: Insomnia is a significant risk factor for depression onset, can result in more disabling depressive illness, and is a common residual symptom following treatment cessation that can increase the risk of relapse. Internet-based cognitive behavioural therapy for insomnia has demonstrated ef mai mult
BMC Psychiatry - Latest Articles
5 Februarie 2015 12:00
Background: Depression represents one of the most common psychiatric disorders among older adults. Married couples are affected frequently, and psychiatric problems usually affect marital satisfaction. Despite the frequency of such relationships, it appears that very few studies have examined the is mai mult
BMC Psychiatry - Latest Articles
5 Februarie 2015 17:00

Immunotherapy of B-cell malignancies using CD19-targeted chimeric antigen receptor–transduced T cells or CD20-targeted therapeutic monoclonal antibodies has shown clinical efficacy. However, refractory disease and the emergence of antigen-loss tumor escape variants after treatment demonstrate the ne

mai mult
Blood current issue
5 Februarie 2015 17:00
5 Februarie 2015 17:00

Thrombopoietin (Thpo) signaling through the c-Mpl receptor promotes either quiescence or proliferation of hematopoietic stem cells (HSCs) in a concentration-dependent manner; however, in vivo Thpo serum levels are responsive to platelet mass rather than HSC demands, suggesting additional regulation

mai mult
Blood current issue
5 Februarie 2015 17:00
5 Februarie 2015 17:00
5 Februarie 2015 17:00
5 Februarie 2015 17:00
5 Februarie 2015 17:00

Defects of the platelet P2Y12 receptor (P2Y12R) for adenosine diphosphate (ADP) are associated with increased bleeding risk. The study of molecular abnormalities associated with inherited qualitative defects of the P2Y12R protein is useful to unravel structure-function relationships of the receptor.

mai mult
Blood current issue
5 Februarie 2015 17:00

Vascular safety is an emerging issue in patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors (TKIs). Whereas imatinib exhibits a well-documented and favorable long-term safety profile without obvious accumulation of vascular events, several types of vascular adverse e

mai mult
Blood current issue
5 Februarie 2015 17:00

Serum cytokines and chemokines may reflect tumor biology and host response in follicular lymphoma (FL). To determine whether the addition of these biological factors may further refine prognostication, 30 cytokines and chemokines were measured in pretreatment serum specimens from newly diagnosed FL

mai mult
Blood current issue
5 Februarie 2015 17:00
5 Februarie 2015 17:00

Translocation of the mixed-lineage leukemia (MLL) gene with AF4, AF9, or ENL results in acute leukemia with both lymphoid and myeloid involvement. We characterized leukemia-initiating cells (LICs) in primary infant MLL-rearranged leukemia using a xenotransplantation model. In MLL-AF4 patients, CD34+

mai mult
Blood current issue
5 Februarie 2015 17:00

To explore how RUNX1 mutations predispose to leukemia, we generated induced pluripotent stem cells (iPSCs) from 2 pedigrees with germline RUNX1 mutations. The first, carrying a missense R174Q mutation, which acts as a dominant-negative mutant, is associated with thrombocytopenia and leukemia, and th

mai mult
Blood current issue
5 Februarie 2015 17:00

Current guidelines for heparin-induced thrombocytopenia (HIT) management recommend heparin cessation and switching to a nonheparin anticoagulant (ie, argatroban, danaparoid) upon clinical suspicion. Fondaparinux may be effective but information supporting its use is limited. We retrospectively evalu

mai mult
Blood current issue
5 Februarie 2015 17:00

Non-Hodgkin lymphomas (NHLs) are the most common cancer to affect pet dogs. In contrast to the many genes whose mutation contributes to lymphomagenesis in humans, relatively little is known about the acquired genetic alterations that lead to canine B-cell lymphomas (cBCLs). We performed a survey of

mai mult
Blood current issue
5 Februarie 2015 17:00

The Therapeutic Intensification in De Novo Leukaemia (TIDEL)-II study enrolled 210 patients with chronic phase chronic myeloid leukemia (CML) in two equal, sequential cohorts. All started treatment with imatinib 600 mg/day. Imatinib plasma trough level was performed at day 22 and if <1000 ng/mL, ima

mai mult
Blood current issue
5 Februarie 2015 17:00

Effective treatment of diffuse large B-cell lymphoma (DLBCL) is plagued by heterogeneous responses to standard therapy, and molecular mechanisms underlying unfavorable outcomes in lymphoma patients remain elusive. Here, we profiled 148 genomes with 91 matching transcriptomes in a DLBCL cohort treate

mai mult
Blood current issue
5 Februarie 2015 17:00

Type 2 von Willebrand disease (VWD) includes a wide range of qualitative abnormalities of von Willebrand factor structure and function resulting in a variable bleeding tendency. According to the current classification, 4 different subtypes can be identified, each with distinctive phenotypic and ther

mai mult
Blood current issue
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