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Jurnale medicale
Anatomie patologica

Jurnale medicale Anatomie patologica

29 Ianuarie 2015 17:00

Dyskeratosis congenita (DC) is an inherited multisystem disorder, characterized by oral leukoplakia, nail dystrophy, and abnormal skin pigmentation, as well as high rates of bone marrow (BM) failure, solid tumors, and other medical problems such as osteopenia. DC and telomere biology disorders (coll

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Blood current issue
29 Ianuarie 2015 17:00
29 Ianuarie 2015 17:00
29 Ianuarie 2015 17:00
29 Ianuarie 2015 17:00
29 Ianuarie 2015 17:00

Autoimmune cytopenia is a frequent manifestation of primary immunodeficiencies. Two siblings presented with Evans syndrome, viral infections, and progressive leukopenia. DNA available from one patient showed a homozygous frameshift mutation in tripeptidyl peptidase II (TPP2) abolishing protein expre

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Blood current issue
29 Ianuarie 2015 17:00
29 Ianuarie 2015 17:00

Acute myeloid leukemia (AML) in older patients presents a notable therapeutic challenge to the clinical hematologist. The clinical biology of AML among patients is highly heterogeneous. Interpatient variations are relevant for prognosis and treatment choice. Outcome of treatment for patients of adva

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Blood current issue
29 Ianuarie 2015 17:00

Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by intravascular hemolysis, which is effectively controlled with eculizumab, a humanized monoclonal antibody that binds complement protein 5 (C5). The residual functional activity of C5 can be screened using a 50% hemolytic complement (CH50)

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Blood current issue
29 Ianuarie 2015 17:00

A specialized form of trogocytosis occurs when Fc receptors on acceptor cells take up and internalize donor cell-associated immune complexes composed of specific monoclonal antibodies (mAbs) bound to target antigens on donor cells. This trogocytosis reaction, an example of antigenic modulation, has

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Blood current issue
29 Ianuarie 2015 17:00

Natural killer (NK) cells can enhance engraftment and mediate graft-versus-leukemia following allogeneic hematopoietic stem cell transplantation (HSCT), but the potency of graft-versus-leukemia mediated by naturally reconstituting NK cells following HSCT is limited. Preclinical studies demonstrate t

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Blood current issue
29 Ianuarie 2015 17:00

We examined immunological responses in patients receiving histone deacetylase (HDAC) inhibition (vorinostat) for graft-versus-host disease prophylaxis after allogeneic hematopoietic cell transplant. Vorinostat treatment increased histone acetylation in peripheral blood mononuclear cells (PBMCs) from

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Blood current issue
29 Ianuarie 2015 17:00

The interaction of lymphoid tumor cells with components of the extracellular matrix via integrin αvβ3 allows tumor survival and growth. This integrin was demonstrated to be the membrane receptor for thyroid hormones (THs) in several tissues. We found that THs, acting as soluble integrin αvβ3 ligands

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Blood current issue
29 Ianuarie 2015 17:00

Patients with t(1;19)-positive acute lymphoblastic leukemia (ALL) are prone to central nervous system (CNS) relapses, and expression of the TAM (Tyro3, Axl, and Mer) receptor Mer is upregulated in these leukemias. We examined the functional role of Mer in the CNS in preclinical models and performed c

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Blood current issue
29 Ianuarie 2015 17:00

The acquisition of the cytogenetic abnormalities hyperdiploidy or translocations into the immunoglobulin gene loci are considered as initiating events in the pathogenesis of myeloma and were often assumed to be mutually exclusive. These lesions have clinical significance; hyperdiploidy or the presence

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Blood current issue
29 Ianuarie 2015 17:00

Bone marrow megakaryocytes produce platelets by extending long cytoplasmic protrusions, designated proplatelets, into sinusoidal blood vessels. Although microtubules are known to regulate platelet production, the underlying mechanism of proplatelet elongation has yet to be resolved. Here we report t

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Blood current issue
29 Ianuarie 2015 17:00

Mice with T-cell–specific loss of the tumor suppressor gene PTEN early in T-cell ontogeny develop thymic lymphomas that invariably harbor a reciprocal translocation involving the T-cell receptor α/ locus and c-myc, t(14;15). In addition to its known function as a lipid phosphatase opposing PI3K signal

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Blood current issue
29 Ianuarie 2015 17:00

An unresolved issue in chronic lymphocytic leukemia (CLL) is whether IGHV3-21 gene usage, in general, or the expression of stereotyped B-cell receptor immunoglobulin defining subset #2 (IGHV3-21/IGLV3-21), in particular, determines outcome for IGHV3-21-utilizing cases. We reappraised this issue in 8

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Blood current issue
29 Ianuarie 2015 17:00

Class IA phosphoinositide 3-kinase β (PI3Kβ) is considered a potential drug target in arterial thrombosis, which is a major cause of death worldwide. Here we show that a striking phenotype of mice with selective p110β deletion in the megakaryocyte lineage is thrombus instability at a high shear rate

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Blood current issue
29 Ianuarie 2015 17:00

Inherited thrombocytopenias (ITs) are a heterogeneous group of syndromic and nonsyndromic diseases caused by mutations affecting different genes. Alterations of ACTN1, the gene encoding for α-actinin 1, have recently been identified in a few families as being responsible for a mild form of IT (ACTN1

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Blood current issue
29 Ianuarie 2015 17:00

Hemoglobin E (HbE) β-thalassemia is the most common severe thalassemia syndrome across Asia, and millions of people are carriers. Clinical heterogeneity in HbE β-thalassemia is incompletely explained by genotype, and the interaction of phenotypic variation with hepcidin is unknown. The effect of tha

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Blood current issue
29 Ianuarie 2015 17:00
29 Ianuarie 2015 17:00
29 Ianuarie 2015 17:00
29 Ianuarie 2015 17:00

The hematopoietically expressed homeobox gene, Hhex, is a transcription factor that is important for development of definitive hematopoietic stem cells (HSCs) and B cells, and that causes T-cell leukemia when overexpressed. Here, we have used an Hhex inducible knockout mouse model to study the role

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Blood current issue
6 Ianuarie 2015 08:17

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a nearly lethal neoplasm. It is a remarkably stroma-rich, vascular-poor and hypo-perfused tumor, which prevents efficient drug delivery. Paradoxically, the neoplastic cells have robust glucose uptake, suggesting the microvasculature has adopted an

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The Journal of Pathology
7 Ianuarie 2015 09:06

Abstract

CaMKII╬┤, a calcium/calmodulin-dependent protein kinase, plays pivotal roles in the development of heart disease. In this issue of the Journal of Pathology, Salma Awad and colleagues demonstrate that CaMKII╬┤ is engaged in both pathological hypertrophy and heart failure. By analysis of mice

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The Journal of Pathology
14 Ianuarie 2015 06:47

Abstract

In diabetic nephropathy (DN), podocyte cytoskeletal rearrangement occurs followed by podocyte effacement and the development of proteinuria. PTEN (phosphatase and tensin homolog) is a ubiquitously expressed phosphatase that plays a critical role in cell proliferation, cytoskeletal rearrange

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The Journal of Pathology
16 Ianuarie 2015 12:49

Abstract

Melanoma is the leading cause of skin cancer mortality. The major cause of melanoma mortality is metastasis to distant organs, frequently to the brain. The microenvironment plays a critical role in tumorigenesis and metastasis. In order to treat or prevent metastasis, the interactions of di

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The Journal of Pathology
22 Ianuarie 2015 17:00

Cytomegalovirus (CMV) remains a significant cause of morbidity after allogeneic hematopoietic stem cell transplantation (HSCT). Clinical risk varies according to a number of factors, including recipient/donor CMV serostatus. Current dogma suggests risk is greatest in seropositive recipient (R+)/sero

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Blood current issue
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