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Jurnale medicale
Anatomie patologica

Jurnale medicale Anatomie patologica

22 Ianuarie 2015 17:00

DNA methyltransferase 3A (DNMT3A) is mutated in hematologic malignancies affecting myeloid, mixed, and lymphoid lineages, and these mutations are associated with poor prognosis. Past studies in mice revealed Dnmt3a-knockout (KO) hematopoietic stem cells (HSCs) had increased self-renewal, but no leuk

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Blood current issue
22 Ianuarie 2015 17:00

The precise mechanism for reduced thrombosis in prekallikrein null mice (Klkb1–/–) is unknown. Klkb1–/– mice have delayed carotid artery occlusion times on the rose bengal and ferric chloride thrombosis models. Klkb1–/– plasmas have long-activated partial thromboplastin times and defective contact a

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Blood current issue
22 Ianuarie 2015 17:00

Genome sequencing studies of patient samples have implicated the involvement of various components of the epigenetic machinery in myeloid diseases, including the de novo DNA methyltransferase DNMT3A. We have recently shown that Dnmt3a is essential for hematopoietic stem cell differentiation. Here, w

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Blood current issue
22 Ianuarie 2015 17:00

Nitric oxide (NO) exerts vasodilatatory, antiplatelet, antioxidant, and antiproliferative effects. Endothelium-derived NO has been shown to be of crucial importance in cardiovascular protection, whereas evidence that NO is synthesized by platelets and regulates platelet function is still controversi

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Blood current issue
22 Ianuarie 2015 17:00

Many patients with syndromes of thrombotic microangiopathy (TMA), including thrombotic thrombocytopenic purpura and hemolytic-uremic syndrome, have been reported to have a drug-induced etiology, and many different drugs have been suspected as a cause of TMA. We established criteria to assess the str

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Blood current issue
22 Ianuarie 2015 17:00

Acute lymphoblastic leukemia (ALL) in adolescents and young adults (AYA) is characterized by distinct presenting features and inferior prognosis compared with pediatric ALL. We performed a genome-wide association study (GWAS) to comprehensively identify inherited genetic variants associated with sus

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Blood current issue
22 Ianuarie 2015 17:00

Chronic graft-versus-host disease (GVHD) remains a common and potentially life-threatening complication of allogeneic hematopoietic stem cell transplantation (HCT). The 2-year cumulative incidence of chronic GVHD requiring systemic treatment is ~30% to 40% by National Institutes of Health criteria.

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Blood current issue
22 Ianuarie 2015 17:00

Follicular lymphoma (FL), an indolent neoplasm caused by a t(14;18) chromosomal translocation that juxtaposes the BCL2 gene and immunoglobulin locus, has a variable clinical course and frequently undergoes transformation to an aggressive lymphoma. Although BCL2 mutations have been previously described

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Blood current issue
22 Ianuarie 2015 17:00

The analyses carried out using 2 different bioinformatics pipelines (SomaticSniper and MuTect) on the same set of genomic data from 133 acute myeloid leukemia (AML) patients, sequenced inside the Cancer Genome Atlas project, gave discrepant results. We subsequently tested these 2 variant-calling pip

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Blood current issue
22 Ianuarie 2015 17:00

The signal transducer and activator of transcription (STAT) family of transcription factors orchestrate hematopoietic cell differentiation. Recently, mutations in STAT1, STAT5B, and STAT3 have been linked to development of immunodysregulation polyendocrinopathy enteropathy X-linked–like syndrome. He

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Blood current issue
22 Ianuarie 2015 17:00

Germline loss-of-function mutations in the transcription factor signal transducer and activator of transcription 3 (STAT3) cause immunodeficiency, whereas somatic gain-of-function mutations in STAT3 are associated with large granular lymphocytic leukemic, myelodysplastic syndrome, and aplastic anemi

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Blood current issue
22 Ianuarie 2015 17:00

The Eph kinases, EphA4 and EphB1, and their ligand, ephrinB1, have been previously reported to be present in platelets where they contribute to thrombus stability. Although thrombus formation allows for Eph-ephrin engagement and bidirectional signaling, the importance specifically of Eph kinase or e

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Blood current issue
22 Ianuarie 2015 17:00
22 Ianuarie 2015 17:00

The precise glycosyltransferase enzymes that mediate selectin-ligand biosynthesis in human leukocytes are unknown. This knowledge is important because selectin-mediated cell tethering and rolling is a critical component of both normal immune response and various vascular disorders. We evaluated the

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Blood current issue
22 Ianuarie 2015 17:00
22 Ianuarie 2015 17:00

Human germinal center–associated lymphoma (HGAL) is specifically expressed only in germinal center (GC) B lymphocytes and GC-derived lymphomas. HGAL protein decreases lymphocyte motility by inhibiting the ability of myosin to translocate actin via direct interaction with F-actin and myosin II and by

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Blood current issue
22 Ianuarie 2015 17:00
22 Ianuarie 2015 17:00

The pathophysiology of severe aplastic anemia (SAA) is immune-mediated destruction of hematopoietic stem and progenitor cells (HSPCs). Most patients respond to immunosuppressive therapies, but a minority transform to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), frequently associa

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Blood current issue
22 Ianuarie 2015 17:00
22 Ianuarie 2015 17:00
22 Ianuarie 2015 17:00

Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma in the Western world. FL cell-intrinsic and cell-extrinsic factors influence FL biology and clinical outcome. To further our understanding of the genetic basis of FL, we performed whole-exome sequencing of 23 highly purified FL

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Blood current issue
20 Ianuarie 2015 14:31

Knijn N, Nagtegaal ID. Guidelines for reporting histopathology studies J Clin Pathol 2014;67:1111–2. Figure 1 and box 1 were left out in the printed PDF version of this article. Please find the complete article below.

Guidelines for reporting histopathology studies

With the increasing amount of publishe

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Journal of Clinical Pathology current issue
20 Ianuarie 2015 14:31
Aims

To establish the human papillomavirus (HPV) type-specific prevalence in cervical cancer and high-grade cervical lesions in the UK prior to the introduction of national HPV vaccination.

Methods

Specimens of cervical cancer (n=1235) and cervical intraepithelial neoplasia (CIN)3 (n=2268) were tes

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Journal of Clinical Pathology current issue
20 Ianuarie 2015 14:31
Aims

To demonstrate clinical application of a mesodissection platform that was developed to combine advantages of laser-based instrumentation with the speed/ease of manual dissection for automated dissection of tissue off standard glass slides.

Methods

Genomic analysis for KRAS gene mutation was pe

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Journal of Clinical Pathology current issue
20 Ianuarie 2015 14:31
Background

Mucosal melanomas (MM) represent a heterogeneous tumour population that exhibits site-specific molecular profiles.

Aims

In a multicentre retrospective study, we investigated KIT aberrations in primary anorectal (AR) melanomas compared with melanoma metastatic to the gastrointestinal (GI)

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Journal of Clinical Pathology current issue
20 Ianuarie 2015 14:31
Aim

Serological indices for liver fibrosis have been widely used to estimate liver fibrosis, but as far as we know they have not been tested to predict hepatocellular carcinoma (HCC). Our aim is to study the clinical usefulness of some simple non-invasive fibrosis indices in the prediction of HCC am

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Journal of Clinical Pathology current issue
20 Ianuarie 2015 14:31
Aim

We studied ERG expression in a large series of chondrogenic bone and soft tissue tumours to assess the value of ERG as a possible marker of chondroid/cartilaginous differentiation.

Methods

Formalin-fixed, paraffin-embedded whole sections from 111 bone and soft tissue tumours with chondroid diff

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Journal of Clinical Pathology current issue
20 Ianuarie 2015 14:31
Aims

The canals of Hering (CoH), which are the most peripherally located bile drainage pathway, are considered a niche of hepatic progenitor cells. Recently, CoH loss has been described as an early feature of primary biliary cirrhosis (PBC). We investigated the correlation between CoH loss and the h

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Journal of Clinical Pathology current issue
20 Ianuarie 2015 14:31
Aims

Primary histopathology of miscarriage remains undetermined in the majority of cases. This study was conducted to determine histological characteristics pertinent to miscarriage.

Methods

The study groups were composed of elective abortions (n=29) and miscarriages (n=45) comprised of chromosomal

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Journal of Clinical Pathology current issue
20 Ianuarie 2015 14:31
Introduction

Cervical metaplastic carcinomas, including most cases of malignant mixed müllerian tumours (MMMTs), or carcinosarcomas, and sarcomatoid carcinomas, are rare biphasic neoplasms.1 2 Recent research suggests that both elements share a common epithelial origin, with sarcomatous/sarcomatoid

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Journal of Clinical Pathology current issue
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