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Cancer Research current issue
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Aesthetic Surgery Journal Allergy Am J Psychiatry current issue American Journal of Clinical Nutrition current issue American Journal of Geriatric Psych - Featured Articles - Featured Articles American Journal of Hematology American Journal of Obstetrics & Gynecology American Journal of Ophthalmology American Journal of Physical Medicine & Rehabilitation - Current Issue Anaesthesia & Intensive Care Medicine Anesthesiology - Current Issue ANZ Journal of Surgery Archives of Physical Medicine and Rehabilitation Arteriosclerosis, Thrombosis, and Vascular Biology current issue
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BioMed Central - Latest Articles Blood current issue BMC Ear, Nose and Throat Disorders - Latest Articles BMC Gastroenterology - Latest Articles BMC Geriatrics - Latest Articles BMC Ophthalmology - Latest Articles BMC Psychiatry - Latest Articles British Journal of Anaesthesia - current issue British Journal of Dermatology British Journal of Ophthalmology current issue
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Cancer Research current issue Cardiovascular Research - current issue CDC HIV/AIDS Prevention Circulation current issue Circulation Research current issue Circulation: Arrhythmia and Electrophysiology current issue Circulation: Cardiovascular Genetics current issue Circulation: Cardiovascular Imaging current issue Circulation: Cardiovascular Interventions current issue Circulation: Cardiovascular Quality and Outcomes current issue Circulation: Heart Failure current issue Cleveland Clinic Journal of Medicine current issue Clinical Diabetes Journal current issue Clinical Endocrinology Clinical Microbiology and Infection Critical Care - Latest Articles Current Issue
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Diabetes Care Journal current issue Diabetes Journal current issue Diabetes Spectrum Journal current issue
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Emergency Medicine Journal current issue European Heart Journal - current issue European Journal of Endocrinology current issue European Journal of Internal Medicine European Journal of Nuclear Medicine and Molecular Imaging (Online First™) European Journal of Nuclear Medicine and Molecular Imaging (Online First™) European Journal of Pediatrics (Online First™) Evidence-Based Medicine current issue
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Gut current issue
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Haematologica current issue Heart current issue Hypertension current issue
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International Journal of Dental Hygiene International Journal of Emergency Medicine International Journal of Nephrology and Renovascular Disease International Journal of Paediatric Dentistry International Journal of Rheumatic Diseases
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JCR: Journal of Clinical Rheumatology - Most Popular Articles Journal of Clinical Oncology Current Issue Journal of Clinical Pathology current issue Journal of Esthetic and Restorative Dentistry Journal of Family Practice Journal of Gastroenterology and Hepatology Journal of Hematology & Oncology - Latest Articles Journal of Human Kinetics Journal of Intensive Care Medicine current issue Journal of Neurology (Online First™) Journal of Neurology, Neurosurgery & Psychiatry current issue Journal of Neuroscience current issue Journal of Occupational Medicine and Toxicology - Latest Articles Journal of Orthopaedic Surgery and Research - Latest Articles Journal of Orthopaedics and Traumatology (Online First™) Journal of Pediatric Surgery Journal of Prosthetic Dentistry Journal of Radiology Case Reports Journal of the American Academy of Dermatology Journal of the American College of Cardiology Current Issue Journal of the American Society of Nephrology current issue
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Latest BMJ blogs Latest Issue of Journal of Dentistry for Children Latest Issue of Journal of Rehabilitation Medicine Legal Medicine
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Massachusetts Medical Society: New England Journal of Medicine: Table of Contents Mayo Clinic Proceedings current issue Medscape Medical News Headlines
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NEO : Last 10 articles Nephrology Nephrology Dialysis Transplantation - current issue Nuclear Medicine and Biology
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Obstetrics & Gynecology - Featured Articles - Editors' Picks Occupational and Environmental Medicine current issue Occupational Medicine - current issue
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Pediatric Surgery International (Online First™) Pediatrics & Neonatology PEDIATRICS current issue Plastic and Reconstructive Surgery - Current Issue PLOS Medicine: New Articles
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Radiographics current issue Radiology current issue Rheumatology - current issue
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ScienceDirect Publication: European Journal of Radiology ScienceDirect Publication: International Journal of Gynecology & Obstetrics Stroke current issue
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The American Journal of Human Genetics The American Journal of Surgery The British Journal of Diabetes & Vascular Disease current issue The Clinical Respiratory Journal The European Journal of Orthodontics - current issue The Journal of Bone & Joint Surgery current issue The Journal of Clinical Endocrinology & Metabolism Current Issue The Journal of Pathology The Journal of Urology The Lancet The Lancet Infectious Diseases The Lancet Neurology The Lancet Oncology The Oncologist current issue
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Jurnale medicale Cancer Research current issue

2 Februarie 2015 05:05
2 Februarie 2015 05:05
2 Februarie 2015 05:05
2 Februarie 2015 05:05
Some patients with soft-tissue sarcoma (STS) report a history of injury at the site of their tumor. Although this phenomenon is widely reported, there are relatively few experimental systems that have directly assessed the role of injury in sarcoma formation. We recently described a mouse model of S mai mult
Cancer Research current issue
2 Februarie 2015 05:05
Ibrutinib (Imbruvica), a small-drug inhibitor of Bruton tyrosine kinase (BTK), is currently undergoing clinical testing in patients with multiple myeloma, yet important questions on the role of BTK in myeloma biology and treatment are outstanding. Using flow-sorted side population cells from human m mai mult
Cancer Research current issue
2 Februarie 2015 05:05
Many epithelial??mesenchymal transition (EMT)??promoting transcription factors have been implicated in tumorigenesis and metastasis as well as chemoresistance of cancer. However, the underlying mechanisms mediating these processes are unclear. Here, we report that Foxq1, a forkhead box-containing mai mult
Cancer Research current issue
2 Februarie 2015 05:05
Global changes in gene expression accompany the development of cancer. Thus, inherited variants in miRNA-binding sites are likely candidates for conferring inherited susceptibility. Using an in silico approach, we compiled a comprehensive list of SNPs predicted to modulate miRNA binding in genes fro mai mult
Cancer Research current issue
2 Februarie 2015 05:05
Breast cancer brain metastasis is resistant to therapy and a particularly poor prognostic feature in patient survival. Altered metabolism is a common feature of cancer cells, but little is known as to what metabolic changes benefit breast cancer brain metastases. We found that brain metastatic breas mai mult
Cancer Research current issue
2 Februarie 2015 05:05
Perinatal factors, including high birth weight, have been associated with childhood brain tumors in case??control studies. However, the specific contributions of gestational age and fetal growth remain unknown, and these issues have never been examined in large cohort studies with follow-up into ad mai mult
Cancer Research current issue
2 Februarie 2015 05:05
Glucose and amino acids are key nutrients supporting cell growth. Amino acids are imported as monomers, but an alternative route induced by oncogenic KRAS involves uptake of extracellular proteins via macropinocytosis and subsequent lysosomal degradation of these proteins as a source of amino acids. mai mult
Cancer Research current issue
2 Februarie 2015 05:05
miR155 is a regulator of immune cell development and function that is generally thought to be immunostimulatory. However, we report here that genetic ablation of miR155 renders mice resistant to chemical carcinogenesis and the growth of several transplanted tumors, suggesting that miR155 functions i mai mult
Cancer Research current issue
2 Februarie 2015 05:05
The prototypic chitinase-like protein Chi3l1 is induced in cancers and portends a poor prognosis, but whether it contributes to cancer progression is unknown. To address this gap in knowledge, we investigated the production of Chi3l1 in melanoma lung metastases. We found that Chi3l1 was induced duri mai mult
Cancer Research current issue
2 Februarie 2015 05:05
Host responses are increasingly considered important for the efficacious response to experimental cancer therapies that employ viral vectors, but little is known about the specific nature of host responses required. In this study, we investigated the role of host type I interferons (IFN-I) in the ef mai mult
Cancer Research current issue
2 Februarie 2015 05:05
Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous disease that develops via one of the two primary carcinogenic routes: chemical carcinogenesis through exposure to tobacco and alcohol or virally induced tumorigenesis. Human papillomavirus (HPV)??positive (HPV+) and HPV-negativ mai mult
Cancer Research current issue
2 Februarie 2015 05:05
Immune rejection of tumors is mediated by IFN? production and T-cell cytolytic activity. These processes are impeded by PD-1, a coinhibitory molecule expressed on T cells that is elevated in tumor-infiltrating lymphocytes (TIL). PD-1 elevation may reflect T-cell exhaustion marked by decreased proli mai mult
Cancer Research current issue
2 Februarie 2015 05:05
CD4 T cells are key components of the immune system that shape the anticancer immune response in animal models and in humans. The biology of CD4 T cells is complex because na??ve T cells can differentiate into various subpopulations with various functions. Recently, a new population called Th9 cells mai mult
Cancer Research current issue
2 Februarie 2015 05:05
The aberrant processes driving hepatocellular carcinoma (HCC) are not fully understood. Lysophosphatidic acid receptors (LPAR) are commonly overexpressed in HCC, but their contributions to malignant development are not well established. In this report, we show that aberrant expression of LPAR6 susta mai mult
Cancer Research current issue
15 Ianuarie 2015 05:05
15 Ianuarie 2015 05:05
KAP1 (TRIM28) is a transcriptional regulator in embryonic development that controls stem cell self-renewal, chromatin organization, and the DNA damage response, acting as an essential corepressor for KRAB family zinc finger proteins (KRAB-ZNF). To gain insight into the function of this large gene fa mai mult
Cancer Research current issue
15 Ianuarie 2015 05:05
Cancer stem cells (CSC) have been implicated in disease recurrence, metastasis, and therapeutic resistance, but effective targeting strategies for these cells are still wanting. VS-5584 is a potent and selective dual inhibitor of mTORC1/2 and class I PI 3-kinases. Here, we report that VS-5584 is up mai mult
Cancer Research current issue
15 Ianuarie 2015 05:05
Beta human papillomaviruses (HPV) have been suspected to be carcinogenic in nonmelanoma skin cancers (NMSC), but the basis for potential viral contributions to these cancers is poorly understood. In particular, it is unresolved how HPV-infected keratinocytes escape cell-cycle control and whether the mai mult
Cancer Research current issue
15 Ianuarie 2015 05:05
Soluble growth factors and cytokines within the tumor microenvironment aid in the induction of the epithelial-to-mesenchymal transition (EMT). Although EMT promotes the development of cancer-initiating cells (CIC), cellular mechanisms by which cancer cells maintain mesenchymal phenotypes remain poor mai mult
Cancer Research current issue
15 Ianuarie 2015 05:05
Clear-cell renal cell cancer (CRCC) is initiated typically by loss of the tumor-suppressor VHL, driving constitutive activation of hypoxia-inducible factor-1 (HIF1) and HIF2. However, whereas HIF1 has a tumor-suppressor role, HIF2 plays a distinct role in driving CRCC. In this study, we show that th mai mult
Cancer Research current issue
15 Ianuarie 2015 05:05
Estrogen receptor (ER) ???positive breast cancers initially respond to antiestrogens but eventually become estrogen independent and recur. ER+ breast cancer cells resistant to long-term estrogen deprivation (LTED) exhibit hormone-independent ER transcriptional activity and growth. A kinome-wide si mai mult
Cancer Research current issue
15 Ianuarie 2015 05:05
Cancer metastasis can occur at early stages of tumor development due to facilitative alterations in the tumor microenvironment. Although imaging techniques have considerably improved our understanding of metastasis, early events remain challenging to study due to the small numbers of malignant cells mai mult
Cancer Research current issue
15 Ianuarie 2015 05:05
The bradykinin receptor B1R is overexpressed in many human cancers where it might be used as a general target for cancer imaging. In this study, we evaluated the feasibility of using radiolabeled kallidin derivatives to visualize B1R expression in a preclinical model of B1R-positive tumors. Three sy mai mult
Cancer Research current issue
15 Ianuarie 2015 05:05
Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) results in complete regression of advanced cancer in some patients, but the efficacy of this potentially curative therapy may be limited by poor persistence of TIL after adoptive transfer. Pharmacologic inhibition of t mai mult
Cancer Research current issue
15 Ianuarie 2015 05:05
Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies, but its genetic drivers remain little understood. In this study, we report losses in expression of the miRNA miR30a, which is downregulated in ATC compared with differentiated thyroid cancer and normal tissue. miR30a downr mai mult
Cancer Research current issue
15 Ianuarie 2015 05:05
Crosstalk between tumor and stromal cells in the tumor microenvironment alter its properties in ways that facilitate the invasive behavior of tumor cells. Here, we demonstrate that cancer-associated fibroblasts (CAF) increase the stiffness of the extracellular matrix (ECM) and promote anisotropic fi mai mult
Cancer Research current issue
15 Ianuarie 2015 05:05
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