Home Jurnale medicale Cardiologie
Jurnale medicale
Cardiologie

Jurnale medicale Cardiologie

7 Februarie 2015 08:05
7 Februarie 2015 08:05
7 Februarie 2015 08:05
Aims

Acute coronary syndromes (ACSs) are driven by inflammation within coronary plaque. Interleukin-1 (IL-1) has an established role in atherogenesis and the vessel-response to injury. ACS patients have raised serum markers of inflammation. We hypothesized that if IL-1 is a driving influence of infl

mai mult
European Heart Journal - current issue
7 Februarie 2015 08:05
7 Februarie 2015 08:05
Aims

This randomized controlled trial (RCT) evaluated whether a process with single combined testing of copeptin and troponin at admission in patients with low-to-intermediate risk and suspected acute coronary syndrome (ACS) does not lead to a higher proportion of major adverse cardiac events (MACE)

mai mult
European Heart Journal - current issue
7 Februarie 2015 08:05
7 Februarie 2015 08:05
7 Februarie 2015 08:05
7 Februarie 2015 08:05
7 Februarie 2015 08:05
7 Februarie 2015 08:05
Aims

Several methods provide new insights into understanding clinical trial composite endpoints, using both conventional and novel methods. The TRILOGY ACS trial is used as a contemporary example to prospectively compare these methods side by side.

Methods and results

The traditional time-to-first-

mai mult
European Heart Journal - current issue
7 Februarie 2015 08:05
7 Februarie 2015 08:05
Aim

Heart disease is recognized as a consequence of dysregulation of cardiac gene regulatory networks. Previously, unappreciated components of such networks are the long non-coding RNAs (lncRNAs). Their roles in the heart remain to be elucidated. Thus, this study aimed to systematically characterize

mai mult
European Heart Journal - current issue
5 Februarie 2015 18:55
5 Februarie 2015 18:55
Background—

Anthracycline-induced cardiotoxicity and myocardial dysfunction may be associated with apoptosis. Caspase 3 catalyzes a terminal step in apoptosis, and its expression may serve as a marker of cardiomyocyte apoptosis. We synthesized 18F-CP18, a caspase-3 substrate and evaluated cardiac 18

mai mult
Circulation: Cardiovascular Imaging current issue
4 Februarie 2015 13:39
Background—

Atrial fibrillation (AF) is associated with left atrial (LA) structural and functional changes. Cardiac magnetic resonance late gadolinium enhancement (LGE) and feature-tracking are capable of noninvasive quantification of LA fibrosis and myocardial motion, respectively. We sought to exa

mai mult
Circulation: Cardiovascular Imaging current issue
29 Ianuarie 2015 21:00

Oxidative stress has long been implicated in cardiovascular disease, but more recently, the role of reactive oxygen species (ROS) in normal physiological signaling has been elucidated. Signaling pathways modulated by ROS are complex and compartmentalized, and we are only beginning to identify the mo

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
Rationale:

To maintain cardiac mechanical and structural integrity after an ischemic insult, profound alterations occur within the extracellular matrix. Osteoglycin is a small leucine-rich proteoglycan previously described as a marker of cardiac hypertrophy.

Objective:

To establish whether osteogly

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00

Autophagy is an important physiological process in the heart, and alterations in autophagic activity can exacerbate or mitigate injury during various pathological processes. Methods to assess autophagy have changed rapidly because the field of research has expanded. As with any new field, methods an

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
Rationale:

A major goal for the treatment of heart tissue damaged by cardiac injury is to develop strategies for restoring healthy heart muscle through the regeneration and repair of damaged myocardium. We recently demonstrated that administration of a specific combination of microRNAs (miR combo) i

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00

There is increasing interest in the role of autophagic flux in maintaining normal vessel wall biology and a growing suspicion that autophagic dysregulation may be a common pathway through which vascular aging and associated pathologies develop. Within endothelial and smooth muscle cells, diverse but

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
Rationale:

The mechanisms leading to an expanded neutrophil and monocyte supply after stroke are incompletely understood.

Objective:

To test the hypothesis that transient middle cerebral artery occlusion (tMCAO) in mice leads to activation of hematopoietic bone marrow stem cells.

Methods and Resul mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00

Autophagy is a catabolic recycling pathway triggered by various intra- or extracellular stimuli that is conserved from yeast to mammals. During autophagy, diverse cytosolic constituents are enveloped by double-membrane vesicles, autophagosomes, which later fuse with lysosomes or the vacuole to degra

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
Rationale:

Proper patterning of the atrioventricular canal (AVC) is essential for delay of electrical impulses between atria and ventricles, and defects in AVC maturation can result in congenital heart disease.

Objective:

To determine the role of canonical Wnt signaling in the myocardium during AVC

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
Rationale:

Preclinical evidence demonstrates that inorganic nitrite, after its in situ conversion to nitric oxide, attenuates consequent myocardial reperfusion injury.

Objective:

We investigated whether intracoronary injection of nitrite during primary percutaneous coronary intervention might impro

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
29 Ianuarie 2015 21:00

Coronary artery disease causes acute myocardial infarction and heart failure. Identifying coronary vascular progenitors and their developmental program could inspire novel regenerative treatments for cardiac diseases. The developmental origins of the coronary vessels have been shrouded in mystery an

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
29 Ianuarie 2015 21:00

Autophagy is a reparative, life-sustaining process by which cytoplasmic components are sequestered in double-membrane vesicles and degraded on fusion with lysosomal compartments. Growing evidence reveals that basal autophagy is an essential in vivo process mediating proper vascular function. Moreove

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
.
1 - 30 din 14989
paginamedicala.ro utilizeaza fisiere de tip cookie pentru a personaliza si imbunatati experienta ta pe website-ul nostru. Prin click pe butonul "Accepta" accepti utilizarea modulelor cookie. Daca ai nevoie de mai multe detalii despre cum functioneaza acestea, citeste Politica de confidentialitate