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Jurnale medicale
Cardiovascular Research - current issue
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Jurnale medicale Cardiovascular Research - current issue

16 Ianuarie 2015 15:25
Aims

Polyunsaturated fatty n-3 acids (PUFAs) have been reported to exhibit antiarrhythmic properties. However, the mechanisms of action remain unclear. We studied the electrophysiological effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on IKs, and on the expression and location

mai mult
Cardiovascular Research - current issue
16 Ianuarie 2015 15:25
Aims

Actin-binding protein filamin A (FLNA) regulates signal transduction important for cell locomotion, but the role of FLNA after myocardial infarction (MI) has not been explored. The main purpose of this study was to determine the impact of endothelial deletion of FLNA on post-MI remodelling of t

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Cardiovascular Research - current issue
16 Ianuarie 2015 15:25
Aims

The NLRP3 inflammasome is activated in the ischaemic heart promoting caspase-1 activation, inflammation, and cell death. Ischaemic injury establishes both a priming signal (transcription of inflammasome components) and a trigger (NLRP3 activation). Whether NLRP3 activation, without priming, ind

mai mult
Cardiovascular Research - current issue
16 Ianuarie 2015 15:25
Aims

Release of norepinephrine (NE) from sympathetic neurons enhances heart rate (HR) and developed force through activation of β-adrenergic receptors, and this sympathoexcitation is a key risk for the generation of cardiac arrhythmias. Studies of β-adrenergic modulation of cardiac function typicall

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Cardiovascular Research - current issue
16 Ianuarie 2015 15:25
Aims

Renalase, an enzyme that can metabolize catecholamine, was recently reported to attenuate the ischaemia/reperfusion (I/R)-induced cardiac injury. This work was undertaken to investigate the functions and regulation mechanisms of renalase in protection against cardiac I/R injury.

Methods and re mai mult
Cardiovascular Research - current issue
16 Ianuarie 2015 15:25
Aims

P2X receptors (P2XRs) mediate sympathetic control and autoregulation of renal circulation triggering preglomerular vasoconstriction, which protects glomeruli from elevated pressures. Although previous studies established a casual link between glomerular susceptibility to hypertensive injury and

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Cardiovascular Research - current issue
16 Ianuarie 2015 15:25
Aims

To examine the role of physiological Akt signalling in pathological hypertrophy through analysis of PHLPP1 (PH domain leucine-rich repeat protein phosphatase) knock-out (KO) mice.

Methods and results

To investigate the in vivo requirement for ‘physiological’ control of Akt activation in cardia

mai mult
Cardiovascular Research - current issue
16 Ianuarie 2015 15:25
16 Ianuarie 2015 15:25
Aims

In this work, we provide novel insight into the morphology of dissecting abdominal aortic aneurysms in angiotensin II-infused mice. We demonstrate why they exhibit a large variation in shape and, unlike their human counterparts, are located suprarenally rather than infrarenally.

Methods and re mai mult
Cardiovascular Research - current issue
16 Ianuarie 2015 15:25
16 Ianuarie 2015 15:25
Aims

Contraction of the heart is regulated by electrically evoked Ca2+ transients (CaTs). H+ ions, the end products of metabolism, modulate CaTs through direct interactions with Ca2+-handling proteins and via Na+-mediated coupling between acid-extruding proteins (e.g. Na+/H+ exchange, NHE1) and Na+/

mai mult
Cardiovascular Research - current issue
16 Ianuarie 2015 15:25
16 Ianuarie 2015 15:25
Aims

Uncoupling protein 3 (UCP3), located in the mitochondrial inner membrane, is cardioprotective, but its mechanisms of preserving mitochondrial function during ischaemia/reperfusion (I/R) are not fully understood. This study investigated whether UCP3 mediates/mimics the cardioprotection of H2O2 p

mai mult
Cardiovascular Research - current issue
16 Ianuarie 2015 15:25
16 Ianuarie 2015 15:25
26 Decembrie 2014 15:53
Aims

S100A1, a 10-kDa, Ca2+-binding protein, is expressed in endothelial cells (ECs) and binds eNOS. Its absence is associated with impaired production of nitric oxide (NO) and mild systemic hypertension. As endothelial dysfunction contributes to clinical and experimental pulmonary hypertension (PH)

mai mult
Cardiovascular Research - current issue
26 Decembrie 2014 15:53
Aims

The recombinant epidermal growth factor-like domain plus the serine/threonine-rich domain of thrombomodulin (rTMD23) promotes angiogenesis and accelerates the generation of activated protein C (APC), which facilitates angiogenesis. The aim of this study was to elucidate the molecular mechanisms

mai mult
Cardiovascular Research - current issue
26 Decembrie 2014 15:53
26 Decembrie 2014 15:53
Aims

The MEK5/Erk5 pathway mediates beneficial effects of laminar flow, a major physiological factor preventing vascular dysfunction. Forced Erk5 activation induces a protective phenotype in endothelial cell (EC) that is associated with a dramatically decreased migration capacity of those cells. Tra

mai mult
Cardiovascular Research - current issue
26 Decembrie 2014 15:53
26 Decembrie 2014 15:53
Aims

The formyl peptide receptor (FPR) subtype FPR2/ALX transduces pro-inflammatory responses and participates in the resolution of inflammation depending on activation. The aim of the present study was to unravel the role of FPR2/ALX signalling in atherosclerosis.

Methods and results

Expression of

mai mult
Cardiovascular Research - current issue
26 Decembrie 2014 15:53
26 Decembrie 2014 15:53
Aims

Our previous study found that A83-01, a small molecule type 1 TGFβ receptor inhibitor, could induce proliferation of postnatal Nkx2.5+ cardiomyoblasts in vitro and enhance their cardiomyogenic differentiation. The present study addresses whether A83-01 treatment in vivo could increase cardiomyo

mai mult
Cardiovascular Research - current issue
26 Decembrie 2014 15:53
26 Decembrie 2014 15:53
Aims

Perilipin-1 (Plin1), exclusively located on the surface of lipid droplets in adipocytes, regulates the storage and hydrolysis of adipose triglycerides. Plin1 deficiency primarily causes low adiposity and aberrant lipolysis in rodents and humans. Here, we investigated whether adipose tissue dysf

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Cardiovascular Research - current issue
26 Decembrie 2014 15:53
26 Decembrie 2014 15:53
26 Decembrie 2014 15:53
Aims

Hypercholesterolaemia is a major risk factor for cardiovascular diseases and has been shown to influence angiogenesis in the hind limb ischaemia (HLI) model. The impaired up-regulation of angiogenic factors seems to be one of the underlying mechanisms for reduced vessel formation. Since we foun

mai mult
Cardiovascular Research - current issue
26 Decembrie 2014 15:53
26 Decembrie 2014 15:53
Aims

Stimulation of β-adrenergic receptors (β-AR) increases cAMP production and contributes to the pathogenesis of cardiac hypertrophy and failure through poorly understood mechanisms. We previously demonstrated that Exchange protein directly activated by cAMP 1 (Epac1)-induced hypertrophy in primar

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Cardiovascular Research - current issue
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