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Jurnale medicale
Circulation Research current issue
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Jurnale medicale Circulation Research current issue

29 Ianuarie 2015 21:00

Oxidative stress has long been implicated in cardiovascular disease, but more recently, the role of reactive oxygen species (ROS) in normal physiological signaling has been elucidated. Signaling pathways modulated by ROS are complex and compartmentalized, and we are only beginning to identify the mo

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
Rationale:

To maintain cardiac mechanical and structural integrity after an ischemic insult, profound alterations occur within the extracellular matrix. Osteoglycin is a small leucine-rich proteoglycan previously described as a marker of cardiac hypertrophy.

Objective:

To establish whether osteogly

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00

Autophagy is an important physiological process in the heart, and alterations in autophagic activity can exacerbate or mitigate injury during various pathological processes. Methods to assess autophagy have changed rapidly because the field of research has expanded. As with any new field, methods an

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
Rationale:

A major goal for the treatment of heart tissue damaged by cardiac injury is to develop strategies for restoring healthy heart muscle through the regeneration and repair of damaged myocardium. We recently demonstrated that administration of a specific combination of microRNAs (miR combo) i

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00

There is increasing interest in the role of autophagic flux in maintaining normal vessel wall biology and a growing suspicion that autophagic dysregulation may be a common pathway through which vascular aging and associated pathologies develop. Within endothelial and smooth muscle cells, diverse but

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
Rationale:

The mechanisms leading to an expanded neutrophil and monocyte supply after stroke are incompletely understood.

Objective:

To test the hypothesis that transient middle cerebral artery occlusion (tMCAO) in mice leads to activation of hematopoietic bone marrow stem cells.

Methods and Resul mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00

Autophagy is a catabolic recycling pathway triggered by various intra- or extracellular stimuli that is conserved from yeast to mammals. During autophagy, diverse cytosolic constituents are enveloped by double-membrane vesicles, autophagosomes, which later fuse with lysosomes or the vacuole to degra

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
Rationale:

Proper patterning of the atrioventricular canal (AVC) is essential for delay of electrical impulses between atria and ventricles, and defects in AVC maturation can result in congenital heart disease.

Objective:

To determine the role of canonical Wnt signaling in the myocardium during AVC

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
Rationale:

Preclinical evidence demonstrates that inorganic nitrite, after its in situ conversion to nitric oxide, attenuates consequent myocardial reperfusion injury.

Objective:

We investigated whether intracoronary injection of nitrite during primary percutaneous coronary intervention might impro

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
29 Ianuarie 2015 21:00

Coronary artery disease causes acute myocardial infarction and heart failure. Identifying coronary vascular progenitors and their developmental program could inspire novel regenerative treatments for cardiac diseases. The developmental origins of the coronary vessels have been shrouded in mystery an

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
29 Ianuarie 2015 21:00

Autophagy is a reparative, life-sustaining process by which cytoplasmic components are sequestered in double-membrane vesicles and degraded on fusion with lysosomal compartments. Growing evidence reveals that basal autophagy is an essential in vivo process mediating proper vascular function. Moreove

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
29 Ianuarie 2015 21:00
29 Ianuarie 2015 21:00
29 Ianuarie 2015 21:00
Rationale:

Trimethylamine-N-oxide (TMAO), a gut microbial-dependent metabolite of dietary choline, phosphatidylcholine (lecithin), and l-carnitine, is elevated in chronic kidney diseases (CKD) and associated with coronary artery disease pathogenesis.

Objective:

To both investigate the clinical pro

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
29 Ianuarie 2015 21:00

Autophagy is an evolutionarily conserved process by which long-lived proteins and organelles are sequestered by autophagosomes and subsequently degraded by lysosomes for recycling. Autophagy is important for maintaining cardiac homeostasis and is a survival mechanism that is upregulated during stres

mai mult
Circulation Research current issue
15 Ianuarie 2015 21:00
Rationale:

CD4+ natural killer T (NKT) cells augment atherosclerosis in apolipoprotein E–deficient (ApoE)–/– mice but their mechanisms of action are unknown.

Objectives:

We investigated the roles of bystander T, B, and NK cells; NKT cell–derived interferon-, interleukin (IL)-4, and IL-21 cytokines;

mai mult
Circulation Research current issue
15 Ianuarie 2015 21:00
Rationale:

Myocardial infarction is a leading cause of death in developed nations, and there remains a need for cardiac therapeutic systems that mitigate tissue damage. Cardiac progenitor cells (CPCs) and other stem cell types are attractive candidates for treatment of myocardial infarction; however

mai mult
Circulation Research current issue
15 Ianuarie 2015 21:00
15 Ianuarie 2015 21:00
15 Ianuarie 2015 21:00
15 Ianuarie 2015 21:00
15 Ianuarie 2015 21:00
Rationale:

Patients with sickle cell disease (SCD) have markers of chronic inflammation, but the mechanism of inflammation and its relevance to patient survival are unknown.

Objective:

To assess the relationship between iron, inflammation, and early death in SCD.

Methods and Results:

Using periphe

mai mult
Circulation Research current issue
15 Ianuarie 2015 21:00
15 Ianuarie 2015 21:00
Rationale:

In some patients with type 2 diabetes mellitus (DM) without hypertension, cardiac hypertrophy and attenuated cardiac function are observed, and this insult is termed diabetic cardiomyopathy. To date, microRNA (miRNAs or miR) functions in diabetic cardiomyopathy remain to be elucidated.

O mai mult
Circulation Research current issue
15 Ianuarie 2015 21:00
Rationale:

Generation of induced cardiac myocytes (iCMs) directly from fibroblasts offers great opportunities for cardiac disease modeling and cardiac regeneration. A major challenge of iCM generation is the low conversion rate of fibroblasts to fully reprogrammed iCMs, which could in part be attrib

mai mult
Circulation Research current issue
15 Ianuarie 2015 21:00
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