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Jurnale medicale
Circulation: Heart Failure current issue
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Jurnale medicale Circulation: Heart Failure current issue

20 Ianuarie 2015 21:01
Background—

We have reported that pro–B-type natriuretic peptide (BNP)-1-108 circulates and is processed to mature BNP1-32 in human blood. Building on these findings, we sought to determine whether proBNP1-108 processed forms in normal circulation are biologically active and stimulate cGMP, and whet

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
20 Ianuarie 2015 21:01
20 Ianuarie 2015 21:01
Background—

New therapeutic approaches to improve cardiac contractility without severe risk would improve the management of acute heart failure. Increasing systolic sodium influx can increase cardiac contractility, but most sodium channel activators have proarrhythmic effects that limit their clinic

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

Exercise training enhances extracellular superoxide dismutase (EcSOD) expression in skeletal muscle and elicits positive health outcomes in individuals with diabetes mellitus. The goal of this study was to determine if enhanced skeletal muscle expression of EcSOD is sufficient to mitigat

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

Angiotensin receptor neprilysin inhibitors (ARNi), beyond blocking angiotensin II signaling, augment natriuretic peptides by inhibiting their breakdown by neprilysin. The myocardial effects of ARNi have been little studied until recently. We hypothesized that LCZ696 attenuates left ventr

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

Stem cell factor (SCF), a ligand of the c-kit receptor, is a critical cytokine, which contributes to cell migration, proliferation, and survival. It has been shown that SCF expression increases after myocardial infarction (MI) and may be involved in cardiac repair. The aim of this study

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

Intravenous inotropic therapy can be used to support children awaiting heart transplantation. Although use of this therapy is discouraged in adults because of poor outcomes, its use in children, particularly outpatient, has had limited evaluation. We aimed to evaluate the safety and effi

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

Extravascular smooth muscle cells are often observed in the endocardium of human failing hearts. Here, we characterized the phenotype of those cells and investigated their physiological significance.

Methods and Results—

We examined left ventricular biopsy specimens obtained from 44 pat

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

Despite the application of proven adult heart failure therapies to children with idiopathic dilated cardiomyopathy (IDC), prognosis remains poor. Clinical experience with phosphodiesterase 3 inhibitors (PDE3i) in pediatric patients with IDC, however, demonstrates improved heart failure s

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

Although resveratrol has multiple beneficial cardiovascular effects, whether resveratrol can be used for the treatment and management of heart failure (HF) remains unclear. In the current study, we determined whether resveratrol treatment of mice with established HF could lessen the detr

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

Vitamin D supplementation may be an inexpensive intervention to reduce heart failure (HF) incidence. However, there are insufficient data to support this hypothesis. This study evaluates whether vitamin D plus calcium (CaD) supplementation is associated with lower rates of HF in postmeno

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

Nuclear factor B (NF-B) is often implicated in contributing to the detrimental effects of cardiac injury. This ostensibly negative view of NF-B competes with its important role in the normal host inflammatory and immune response. We have previously demonstrated that pharmacological inhib

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

Invasive hemodynamic exercise testing is commonly used in the evaluation of patients with suspected heart failure with preserved ejection fraction (HFpEF) or pulmonary hypertension. Saline loading has been suggested as an alternative provocative maneuver, but the hemodynamic changes indu

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

Heart failure with preserved ejection fraction (HFPEF) is common and characterized by exercise intolerance and lack of proven effective therapies. Exercise training has been shown to be effective in improving cardiorespiratory fitness (CRF) in patients with systolic heart failure. In thi

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

Cardiovascular diseases are the major cause of mortality among both men and women with a lower incidence in women before menopause. The clinical use of doxorubicin, widely used as an antineoplastic agent, is markedly hampered by severe cardiotoxicity. Even if there is a significant sex d

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

Heart failure is a leading cause of morbidity and mortality in the USA and is closely associated with diabetes mellitus. The molecular link between diabetes mellitus and heart failure is incompletely understood. We recently demonstrated that insulin receptor substrates 1, 2 (IRS1, 2) are

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

Heart failure with preserved ejection fraction (HFpEF) represents a growing health burden associated with substantial mortality and morbidity. Consequently, risk prediction is of highest importance. Endothelial dysfunction has been recently shown to play an important role in the complex

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

Induced pluripotent stem cells (iPSCs) can be differentiated into potentially unlimited lineages of cell types for use in autologous cell therapy. However, the efficiency of the differentiation procedure and subsequent function of the iPSC-derived cells may be influenced by epigenetic fa

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

Characteristics and outcomes of patients with heart failure and reduced ejection fraction receiving care at Veterans Affairs (VA) versus non-VA hospitals have not been previously reported.

Methods and Results—

In the randomized controlled Beta-blocker Evaluation of Survival Trial (BEST;

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

The failing heart displays increased glycolytic flux that is not matched by a commensurate increase in glucose oxidation. This mismatch induces increased anaplerotic flux and inefficient glucose metabolism. We previously found adult transgenic mouse hearts expressing the fetal troponin I

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

Heart failure (HF) guidelines recommend screening for cognitive impairment (CI) but do not identify how. The Mini-Cog is an ultrashort cognitive "vital signs" measure that has not been studied in patients hospitalized for HF. The purpose of this study was to evaluate whether CI as assess

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
20 Ianuarie 2015 21:01
Background—

Tumor necrosis factor (TNF) signaling protects against ischemia/reperfusion–induced cardiomyocyte death, in vitro, ex vivo, and in vivo. TNF-receptor–associated factor 2 (TRAF2), an E3 ubiquitin ligase, coordinates cytoprotective signaling downstream of both TNF receptors, via unclear me

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
Background—

We previously reported that specialized and housekeeping genes are differentially regulated via de novo recruitment and pause-release of RNA polymerase II, respectively, during cardiac hypertrophy. However, the significance of this finding remains to be examined. Therefore, the purpose o

mai mult
Circulation: Heart Failure current issue
20 Ianuarie 2015 21:01
20 Ianuarie 2015 21:01
20 Ianuarie 2015 21:01
18 Noiembrie 2014 21:01
18 Noiembrie 2014 21:01
Background—

Elevated high-sensitivity troponin is associated with increasing disease severity in patients with stable heart failure with reduced ejection fraction, but less is known about the association in heart failure with preserved ejection fraction.

Methods and Results—

We examined the prevale

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Circulation: Heart Failure current issue
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