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Jurnale medicale
Clinical Endocrinology
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Jurnale medicale Clinical Endocrinology

7 Februarie 2015 14:26

Summary

Objective

To investigate the response of serum fibroblast growth factor 21 (FGF21) to a meal and to insulin infusion in haemodialysis (HD) patients.

Design and Patients

Meal study: in a cross-over design, 12 non-diabetic HD patients were randomly assigned to: 1) a non-HD day with one meal serv

mai mult
Clinical Endocrinology
7 Februarie 2015 14:26

Abstract

Objectives

Lower circulating androgens and poorer lung function are associated with increased cardiovascular risk and mortality in men. The association between androgens and lung function is unclear. We tested the hypothesis that circulating testosterone (T) and its metabolites dihydrotestos

mai mult
Clinical Endocrinology
5 Februarie 2015 14:12

Abstract

Objective

Serum thyroglobulin (Tg) is a marker of residual differentiated thyroid cancer (DTC) after total thyroidectomy, however circulating anti-thyroglobulin antibodies (TgAb) may interfere with the immunoassay for Tg. Ultrasensitive assays may have a more significant role in detecting ci

mai mult
Clinical Endocrinology
30 Ianuarie 2015 12:05

Summary

Objective

Insulin resistance and subclinical inflammation are characteristics in the development of type 2 diabetes mellitus (T2DM). The adipokine chemerin has been associated with both factors. The aim of this study was to analyse whether chemerin predicts T2DM.

Design

Blood samples of 440 pa

mai mult
Clinical Endocrinology
31 Ianuarie 2015 07:46

Abstract

Objective

A calcium load to suppress PTH secretion can help to perform the diagnosis in some case of primary hyperparathyroidism (PHPT) with atypical presentation. A similar test with calcimimetic, that avoids hypercalcemia, would be of interest. Our proof of concept study was conducted to c

mai mult
Clinical Endocrinology
1 Februarie 2015 10:28

Abstract

Addison's disease is associated with low bone mineral density and increased risk of hip fractures. Causes are multi-factorial, contributed by underlying adrenocortical hormonal deficiency, associated autoimmune endocrinopathies, electrolyte disturbances, and in some patients, supra-physiolo

mai mult
Clinical Endocrinology
2 Februarie 2015 06:56

Abstract

Acromegaly is a chronic disorder usually diagnosed late in the disease evolution. Such delayed diagnosis may result in substantial morbidity and mortality as well as the inability to achieve the treatment goals of normalizing biochemical disease markers and controlling tumour mass without h

mai mult
Clinical Endocrinology
2 Februarie 2015 06:57

Abstract

Objective

The association of low vitamin D status with mild cognitive impairment (MCI), a preclinical condition that can lead to dementia, has not yet been fully explored. Our aim was to investigate the association between vitamin D status and the future risk of MCI and dementia in older adu

mai mult
Clinical Endocrinology
2 Februarie 2015 06:57

Abstract

Objective

To examine associations between metabolic syndrome (MetS) and its individual components with risk of mild cognitive impairment (MCI) among community elderly and explore the age difference.

Design

Cross-sectional study.

Subjects

2,102 aged 60 and older community residents in Beijing m

mai mult
Clinical Endocrinology
2 Februarie 2015 06:58

Abstract

Objective

There are no consistent data on the prevalence and bone status of normocalcaemic hypoparathyroidism (NHYPO) as defined by normal adjusted calcium and low PTH level. Our aim was to determine the prevalence and the metabolic bone profile of NHYPO in older women, assessing its evoluti

mai mult
Clinical Endocrinology
3 Februarie 2015 16:16

Summary

Objective

It has been reported that the positive feedback mechanism of estrogens and progesterone is preserved, although attenuated, in late postmenopausal years. Whether this is also true for the positive feedback effect of estrogens alone has not been investigated.

Design

Prospective interve

mai mult
Clinical Endocrinology
27 Ianuarie 2015 10:11

Abstract

Glucocorticoid hormones are essential for life in vertebrates. They act through the glucocorticoid receptor, which is expressed in virtually all cells of the human body. Yet the actions of glucocorticoids are specific to particular cell types. Broadly glucocorticoids regulate carbohydrate m

mai mult
Clinical Endocrinology
6 Ianuarie 2015 13:50

Abstract

Objective

Follistatin (FST) is a regulator of the biological activity of activin A (Act A), binding and blocking it, which could contribute to the modulation of its pro-inflammatory activity during pregnancy. We sought to investigate, in this nested case-control study, FST serum levels durin

mai mult
Clinical Endocrinology
8 Ianuarie 2015 13:26

Brown adipose tissue (BAT) in the supraclavicular and perirenal regions plays a key role in mammalian energy balance and has been proposed as a promising candidate to reduce the spread of the obesity epidemic (1, 2). Urged by the connection between brown adipocytes and muscle cells (3, 4) as well as

mai mult
Clinical Endocrinology
9 Ianuarie 2015 04:21

Abstract

Objective

Total urinary cortisol and metabolites represents cortisol production and metabolism. We hypothesised that to assay metabolites could add some information to the one provided by a sole cortisol assay.

Design and patients

We set up an inexpensive multiplex mass spectrometry assay to

mai mult
Clinical Endocrinology
12 Ianuarie 2015 07:09

Abstract

We strongly disagree with the commentary on our paper set out by Ahmet Ucar that ??Age-related serum dehydroepiandrosterone sulphate (DHEA-S) levels per se should not be considered a reliable surrogate parameter for clinical presentation of adrenarche? as it reflects a clear misunderstan

mai mult
Clinical Endocrinology
12 Ianuarie 2015 07:10

Abstract

Objective

To evaluate the association between subclinical thyroid dysfunction and psychiatric disorders using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

Design

Cross-sectional study.

Patients

The study included 12,437 participants from the ELSA-Brasil wi

mai mult
Clinical Endocrinology
12 Ianuarie 2015 07:14

Abstract

Objective

This study aimed to assess insulin resistance according to maternal age at childbirth.

Patients and methods

The data used in this study were obtained from the 2010 Korean National Health and Nutrition Examination Survey. The present study included a total of 2,233 non-diabetic femal

mai mult
Clinical Endocrinology
19 Ianuarie 2015 10:33

Abstract

Background

It is unclear whether the rate of Vitamin D deficiency in paediatric cancer survivors is higher than in the background population, and whether this is of pathological significance

Patients and Methods

25OHD was measured in a previously studied group of 208 survivors (n=108 paediatr

mai mult
Clinical Endocrinology
19 Ianuarie 2015 10:35

Abstract

Background

Thyroid cancer incidence has been increasing worldwide. Some suggest greater ascertainment of indolent tumours is the only driver, but others suggest there has been a true increase. Increases in Australia appear to have been among the largest in the world so we investigated incide

mai mult
Clinical Endocrinology
19 Ianuarie 2015 10:42

Abstract

Objectives

This study aimed to evaluate an association between testosterone, sex hormone binding globulin, and body composition as well as the influence of genetic and environmental factors on the association.

Design

A cross-sectional study.

Setting

community-based study.

Participants

1,083 Kor

mai mult
Clinical Endocrinology
19 Ianuarie 2015 10:43

Abstract

Further to the paper by Chng et al, entitled ??Value of sonographic features in predicting malignancy in thyroid nodules diagnosed as follicular neoplasm on cytology?, published in the 2014 December issue of Clinical Endocrinology, we wish to make the following comments:

(a) We agree th

mai mult
Clinical Endocrinology
19 Ianuarie 2015 10:43

Summary

Objective

Graves?? disease, one of the commonest autoimmune disorders, has a complex genetic basis. Interleukin-17A (IL-17A) is an important cytokine involved in innate and adaptive immune responses. This case-control study sought to investigate genetic association between the IL-17A gene an

mai mult
Clinical Endocrinology
20 Ianuarie 2015 09:17

Abstract

Background

An unfavorable cardiovascular and metabolic phenotype causes 3-fold excess mortality in Turner syndrome (TS), and perturbed cardiac substrate metabolism is increasingly recognized as a common component of cardiovascular and metabolic diseases. We therefore hypothesized that myocar

mai mult
Clinical Endocrinology
22 Ianuarie 2015 14:10

Invasive macrocorticotropinomas are frequently refractory to surgery and radiotherapy, medical therapies being generally useless. First publications of treatment with the alkylating agent temozolomide (TMZ) appeared in 2006 and since then, variable responses have been published 1, 2 We report here t

mai mult
Clinical Endocrinology
24 Ianuarie 2015 07:38

Abstract

Objectives

To validate the diagnostic utility of Cortrosyn?? stimulated aldosterone in the differentiation of primary (PAI) and secondary adrenal insufficiency (SAI); and to evaluate the effect of urine sodium levels and posture on test performance.

Design

Cross-sectional study.

Methods

Healt

mai mult
Clinical Endocrinology
2 Ianuarie 2015 06:38

Abstract

Objective

A possible association between serum 25-hydroxyvitamin D and testosterone levels has been reported, however, contradictory results have emerged.

Design

To investigate a causal link between vitamin D and testosterone status, we studied the effect of vitamin D supplementation on serum

mai mult
Clinical Endocrinology
2 Ianuarie 2015 06:41

Summary

A 23-year-old woman with metastatic phaeochromocytoma was found to have a previously unclassified variant in the von Hippel Lindau disease gene (c.361G>C). We use this case to highlight the issue of unclassified single nucleotide variants and the approaches to help predict whether they are d

mai mult
Clinical Endocrinology
2 Ianuarie 2015 06:41

Abstract

Background

Non-invasive stress tests for the diagnosis of significant coronary arterial stenosis requiring intervention are not perfect. We investigated whether plasma metabolome during the oral glucose tolerance test (OGTT) can improve the diagnosis.

Methods

A total of 117 subjects with posi

mai mult
Clinical Endocrinology
31 Decembrie 2014 07:06

Abstract

Objective

Report the prevalence of parathyroid carcinoma (PC) in patients with multiple endocrine neoplasia type 1 (MEN1) and review of the literature.

Background

Primary hyperparathyroidism (PHP) is the most common manifestation of MEN1. The occurrence of PC in patients with MEN1 is rare and

mai mult
Clinical Endocrinology
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