Jurnale medicale Dermatovenerologie
Reducing healthcare-associated infections (HCAI) has been a priority in the UK over recent decades and this has been reflected in interventions focussing on improving hygiene procedures.
to evaluate whether these interventions coincided with an increased incidence of work
Pruritus (itching) can be a distressing symptom, and previous research suggests that it is common in patients with chronic heart failure (CHF).
The primary aim was to examine the prevalence of itching in patients with CHF and to compare this first to that among patients
The histopathologic features of drug rash with eosinophilia and systemic symptoms (DRESS) remain poorly characterized.
To better characterize the histopathological features of DRESS and to define the phenotype of the effector cells in the skin, and to make a comparison wi
Solitary pink tumors represent a diagnostic challenge for clinicians since they often reveal subtle clinical and dermoscopic features. Reflectance confocal microscopy (RCM) has been shown to improve the accuracy for the diagnosis of amelanotic melanoma and basal cell carcinoma.
I read with great interest the work by Johannesdottir et¬†al 1 (and associated editorial commentary commentary2) which reported an increased incidence of cancer in patients diagnosed with pruritus in a secondary care setting. The authors are to be commended for the comprehensive nature of t
As transformed mycosis fungoides (TMF) large-cells may express CD30 antigen, the differential diagnosis between CD30-rich TMF and primary cutaneous anaplastic large cell lymphoma (cALCL) may be difficult, especially to distinguish cALCL associated with MF vs CD30-rich TMF.
We read with great interest the U.K. experience of cutaneous side-effects of first generation HCV (Hepatitis C Virus) protease inhibitors.1 The majority of these reactions are mild/moderate and are generally similar to those observed with peginterferon/ribavirin, including xerosis, pruritus, and ecz
I read with great interest the letter by Taylor and Bhagwandas in the November issue of the BJD.1 The prospect of a safe and effective oral treatment (N-acetylcysteine, NAC) for trichotillomania and related disorders is appealing and encouraging. However, as a clinician with an interest in psychoder
Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease resulting from interaction of genetic, immunological and environmental factors1. IgE-mediated autoimmunity (‚??autoallergy‚?Ě) is a known pathogenetic factor2. Autoallergy to human manganese superoxide dismutase (hMnSOD) in
Lipoedema of the legs is a chronic disorder of adipose tissue, characterized by bilateral, symmetric lower extremity enlargement due to subcutaneous deposition of fat which occurs almost exclusively in women 1. The excess fat deposit usually extends from the waist to a distinct line just above the a
Vorinostat is the first histone deacetylase inhibitor approved for cutaneous T cell lymphoma (CTCL).1 Although in vitro effects of this drug on various types of cells have been studied,2-5 little is known about how this drug has clinical effects on CTCL patients. As many chemokines are reported to r
Lenalidomide, as monotherapy or in combination with dexamethasone, is an immune modulatory drug for the treatment of multiple myeloma, myelodysplastic syndromes and systemic amyloidosis.1 Although cutaneous adverse drug reactions (cADR) are a well-known complication of lenalidomide, perforating foll
Basal cell carcinoma (BCC) can be classified into a number of different clinical and histopathological types.1 The clinical diagnosis is not always consistent with the histopathological diagnosis because BCC does not have a definite clinical appearance in all cases. Accordingly, the extent of tumour
Cowpox viruses (CPXV) are orthopoxviruses (OPV) and belong to the family of poxviridae, which are linear double-stranded DNA viruses. CPXV share common antigens with the smallpox virus, vaccinia virus and monkeypox virus, which also belong to the genus orthopoxvirus. OPV can survive in the environme
Objective outcome measures for melasma severity are essential for the evaluation of severity as well as results of treatment. The modified MASI score (mMASI) is a validated tool for assessing melasma severity but is often subject to inter-observer variability.
Dowling‚??Degos disease (DDD) is a rare autosomal dominant genetic pigmentary disorder characterized by dot-like or reticulate, slightly depressed, sharply demarcated brown macules particularly affecting the flexures and other major skin folds (Fig. 1a).1 There has long been controversy over whether
Darier disease (DD), also known as dyskeratosis follicularis, keratosis follicularis, or Darier-White disease, a genodermatosis with autosomal inheritance, is characterized by multiple, red-to-brown, crusted, follicular- and non-follicular, hyperkeratotic papules preferentially affecting the scalp,
Sebaceous gland carcinoma (SGC) is a tumor of pilosebaceous unit associated with hair follicle and predominantly occurs in eyelid due to abundance of sebaceous glands (Meibomian/Zeiss).1Higher incidence of SGC has been reported from China and India.2 Wnt/ő?-catenin signalling plays an important role
Mycosis Fungoides (MF) is the most frequent cutaneous T-cell lymphoma but its etiology remains largely unknown. Typically, it presents as erythematous patches or plaques located mainly on sun protected areas, progressing to indurated plaques, tumors or erythroderma. During early stages, diagnosis ma
Human papillomavirus (HPV) infections are normally controlled by an intact cell-mediated and humoral immune system. Patients with cell-mediated immunodeficiencies, whether primary, secondary or iatrogenic are all, therefore, at increased risk of developing extensive, persistent and recurrent warts.1
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis that is defined by heterogeneous multi-organ involvement. Due to rarity of disease strong evidence based therapies have yet to be established and prognosis has previously been considered to be poor, with more than hal
Discoid lupus erythematosus (DLE) causes scarring and inflammation and therefore it is not surprising that the psychological impact is considerable1. Patients‚?? subjective perceptions of their condition may be a better predictor of psychological outcomes than clinician-based assessments of severity
The Ichthyosiform dermatoses are hereditary conditions in which genetic mutations alter the normal development and function of keratinocytes, causing a defect in skin desquamation.1 Secondary ectropion and cicatricial eyelid retraction are commonly seen, often causing significant functional and cosm
Despite established pathogenic role of anti-desmoglein (Dsg) antibodies in classical pemphigus, significance of autoantibodies to another desmosomal cadherin, desmocollin (Dsc), is at present unknown. No consistent immunoassay for IgG autoantibodies to Dscs has been developed.
A recent proposal of the concept of immune memory in peripheral tissue mediated by resident memory T cells has enhanced our understanding of skin diseases. These resident memory T cells can provide long-lasting, local, and rapid responses to pathogen reexposure, but can also contribute to inflammato
Solar ultraviolet (UV) radiation is recognised as the principal environmental cause of skin cancer. In particular, the risk of induction of squamous cell carcinoma (SCC) has been shown to increase with cumulative exposure to UV radiation. Models of risk of SCC induction have been developed
Psoriasis is a common chronic inflammatory disorder of the skin frequently characterized by relapsing thick scaling plaques, with or without nail and joint involvement.1 While not life threatening, psoriasis may cause substantial disability subsequent to both physical discomfort (e.g. pruritus, arth