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Jurnale medicale
Endocrinologie

Jurnale medicale Endocrinologie

6 Februarie 2015 11:54
Objective

The effects of vitamin D in the elderly are inconsistent. The aim of this study was to evaluate the association between vitamin D status and the metabolic syndrome (MetS) in the elderly, as well as between vitamin D status and the components of MetS (i.e. serum glucose, triglycerides (TG),

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Background

Reports conflict concerning measurements of plasma metanephrines (MNs) for diagnosis of pheochromocytomas/paragangliomas (PPGLs) by immunoassays compared with other methods. We aimed to compare the performance of a commercially available enzyme-linked immunoassay (EIA) kit with liquid chr

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

Management of insulinomas in the context of MEN1 remains poorly studied. The aim of this study was to evaluate long-term results of various surgical approaches in a large cohort of insulinoma–MEN1 patients.

Design and methods

Consecutive insulinoma–MEN1 patients operated on for a nonmetas

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Context and objective

Patients with cranial diabetes insipidus (CDI) are at risk of developing both hypernatraemia and hyponatraemia, due to the condition itself or secondary to treatment with vasopressin-analogues or during administration of i.v. fluids. We aimed to assess the frequency and impact

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

MicroRNAs (miRNAs) are involved in the regulation of adiposity, but functional studies have yielded inconclusive results. Examining the associations of circulating miRNAs levels with obesity and insulin sensitivity in humans may lead to improved insights.

Design and methods

Serum samples

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

The objective was to assess the amount of vitamin D3 stored in adipose tissue after long-term supplementation with high dose vitamin D3.

Design

A cross-sectional study on 29 subjects with impaired glucose tolerance who had participated in a randomized controlled trial with vitamin D3 20 0

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

Mutations in the glucokinase (GCK) gene, along with hepatocyte nuclear factor 1A (HNF1A) gene mutations, are the most frequent cause of maturity-onset diabetes of the young (MODY). GCK-MODY patients are typically characterized by a moderate fasting hyperglycemia; however, little is known ab

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

To assess whether single nucleotide polymorphisms of HSD17B5 (AKR1C3) (rs1937845 and rs12529) and HSD17B6 (rs898611) are associated with polycystic ovary syndrome (PCOS) in a Chinese population.

Design

A case–control study was conducted to investigate the relation between HSD17B5 and HSD1

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

Germany was iodine deficient until the mid-1990s when a nationwide iodine fortification program became effective. It is expected that after a longer period of sufficient iodine supply, median TSH values in the general population will shift to the right. Hence, the previous TSH reference ra

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54

Mineralocorticoid receptor antagonists have been used in patients with aldosterone-producing adenomas (APAs) as a test designed to predict the blood pressure (BP) outcome of surgery. They are commonly used in patients undergoing adrenalectomy to reduce BP and increase plasma potassium levels during

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

There are scarce reports regarding the prognosis of a second course of antithyroid drug (ATD) therapy on recurrent Graves' disease (GD). The aim of this study was to assess the long-term remission rate after a second ATD therapy and verify significant clinical predictors of a remission.

D mai mult
European Journal of Endocrinology current issue
6 Februarie 2015 11:54

Adrenal crisis is a life-threatening emergency contributing to the excess mortality of patients with adrenal insufficiency. Studies in patients on chronic replacement therapy for adrenal insufficiency have revealed an incidence of 5–10 adrenal crises/100 patient years and suggested a mortality rate

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

To obtain structured information on the diagnostic delay in patients with Cushing's disease (CD) from the patients perspective to provide leverage points for earlier diagnosis.

Design

The study includes 176 patients with ACTH-dependent CD who had received pituitary surgery completed a sel

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

Diabetes mellitus (DM) is associated with endothelial dysfunction, reducing nitric oxide-dependent vasodilation, and increasing production of pro-inflammatory factors, leading to an increased risk of long-term cardiovascular disease. As the effects of phosphodiesterase 5 inhibitors (PDE5i)

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54

Recently, an increased incidence of central diabetes insipidus (CDI) in pregnancy, and less frequently in the post partum period, has been reported, most probably favoured by some conditions occurring in pregnancy. This study was aimed at investigating the influence of pregnancy on a pre-existing po

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

To review the published literature on the effects of telecare intervention in patients with type 2 diabetes and inadequate glycemic control.

Design and methods

A review of randomized controlled trials on telecare intervention in patients with type 2 diabetes, and a search of electronic da

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

Intravenous glucocorticoid (i.v.GC) pulse therapy for Graves' ophthalmopathy (GO) can be associated with acute liver damage (ALD), which was roughly estimated to occur in ~1% of patients, with an overall mortality of 0.4%. The aim of this study was to evaluate the frequency of ALD after th

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European Journal of Endocrinology current issue
6 Februarie 2015 11:54
Objective

Specific germline mutations in the RET proto-oncogene are correlated with clinical features in multiple endocrine neoplasia type 2A (MEN2A); however, data are scarce regarding differences in clinical profiles dependent on the type of nucleotide and amino acid substitution at the same codon

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European Journal of Endocrinology current issue
7 Februarie 2015 14:26

Summary

Objective

To investigate the response of serum fibroblast growth factor 21 (FGF21) to a meal and to insulin infusion in haemodialysis (HD) patients.

Design and Patients

Meal study: in a cross-over design, 12 non-diabetic HD patients were randomly assigned to: 1) a non-HD day with one meal serv

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Clinical Endocrinology
7 Februarie 2015 14:26

Abstract

Objectives

Lower circulating androgens and poorer lung function are associated with increased cardiovascular risk and mortality in men. The association between androgens and lung function is unclear. We tested the hypothesis that circulating testosterone (T) and its metabolites dihydrotestos

mai mult
Clinical Endocrinology
5 Februarie 2015 14:12

Abstract

Objective

Serum thyroglobulin (Tg) is a marker of residual differentiated thyroid cancer (DTC) after total thyroidectomy, however circulating anti-thyroglobulin antibodies (TgAb) may interfere with the immunoassay for Tg. Ultrasensitive assays may have a more significant role in detecting ci

mai mult
Clinical Endocrinology
30 Ianuarie 2015 12:05

Summary

Objective

Insulin resistance and subclinical inflammation are characteristics in the development of type 2 diabetes mellitus (T2DM). The adipokine chemerin has been associated with both factors. The aim of this study was to analyse whether chemerin predicts T2DM.

Design

Blood samples of 440 pa

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Clinical Endocrinology
31 Ianuarie 2015 07:46

Abstract

Objective

A calcium load to suppress PTH secretion can help to perform the diagnosis in some case of primary hyperparathyroidism (PHPT) with atypical presentation. A similar test with calcimimetic, that avoids hypercalcemia, would be of interest. Our proof of concept study was conducted to c

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Clinical Endocrinology
1 Februarie 2015 10:28

Abstract

Addison's disease is associated with low bone mineral density and increased risk of hip fractures. Causes are multi-factorial, contributed by underlying adrenocortical hormonal deficiency, associated autoimmune endocrinopathies, electrolyte disturbances, and in some patients, supra-physiolo

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Clinical Endocrinology
2 Februarie 2015 06:56

Abstract

Acromegaly is a chronic disorder usually diagnosed late in the disease evolution. Such delayed diagnosis may result in substantial morbidity and mortality as well as the inability to achieve the treatment goals of normalizing biochemical disease markers and controlling tumour mass without h

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Clinical Endocrinology
2 Februarie 2015 06:57

Abstract

Objective

The association of low vitamin D status with mild cognitive impairment (MCI), a preclinical condition that can lead to dementia, has not yet been fully explored. Our aim was to investigate the association between vitamin D status and the future risk of MCI and dementia in older adu

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Clinical Endocrinology
2 Februarie 2015 06:57

Abstract

Objective

To examine associations between metabolic syndrome (MetS) and its individual components with risk of mild cognitive impairment (MCI) among community elderly and explore the age difference.

Design

Cross-sectional study.

Subjects

2,102 aged 60 and older community residents in Beijing m

mai mult
Clinical Endocrinology
2 Februarie 2015 06:58

Abstract

Objective

There are no consistent data on the prevalence and bone status of normocalcaemic hypoparathyroidism (NHYPO) as defined by normal adjusted calcium and low PTH level. Our aim was to determine the prevalence and the metabolic bone profile of NHYPO in older women, assessing its evoluti

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Clinical Endocrinology
3 Februarie 2015 16:16

Summary

Objective

It has been reported that the positive feedback mechanism of estrogens and progesterone is preserved, although attenuated, in late postmenopausal years. Whether this is also true for the positive feedback effect of estrogens alone has not been investigated.

Design

Prospective interve

mai mult
Clinical Endocrinology
27 Ianuarie 2015 10:11

Abstract

Glucocorticoid hormones are essential for life in vertebrates. They act through the glucocorticoid receptor, which is expressed in virtually all cells of the human body. Yet the actions of glucocorticoids are specific to particular cell types. Broadly glucocorticoids regulate carbohydrate m

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Clinical Endocrinology
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