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Jurnale medicale
European Heart Journal - current issue
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Jurnale medicale European Heart Journal - current issue

7 Februarie 2015 08:05
7 Februarie 2015 08:05
7 Februarie 2015 08:05
Aims

Acute coronary syndromes (ACSs) are driven by inflammation within coronary plaque. Interleukin-1 (IL-1) has an established role in atherogenesis and the vessel-response to injury. ACS patients have raised serum markers of inflammation. We hypothesized that if IL-1 is a driving influence of infl

mai mult
European Heart Journal - current issue
7 Februarie 2015 08:05
7 Februarie 2015 08:05
Aims

This randomized controlled trial (RCT) evaluated whether a process with single combined testing of copeptin and troponin at admission in patients with low-to-intermediate risk and suspected acute coronary syndrome (ACS) does not lead to a higher proportion of major adverse cardiac events (MACE)

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European Heart Journal - current issue
7 Februarie 2015 08:05
7 Februarie 2015 08:05
7 Februarie 2015 08:05
7 Februarie 2015 08:05
7 Februarie 2015 08:05
7 Februarie 2015 08:05
Aims

Several methods provide new insights into understanding clinical trial composite endpoints, using both conventional and novel methods. The TRILOGY ACS trial is used as a contemporary example to prospectively compare these methods side by side.

Methods and results

The traditional time-to-first-

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European Heart Journal - current issue
7 Februarie 2015 08:05
7 Februarie 2015 08:05
Aim

Heart disease is recognized as a consequence of dysregulation of cardiac gene regulatory networks. Previously, unappreciated components of such networks are the long non-coding RNAs (lncRNAs). Their roles in the heart remain to be elucidated. Thus, this study aimed to systematically characterize

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European Heart Journal - current issue
2 Februarie 2015 10:14
2 Februarie 2015 10:14
2 Februarie 2015 10:14
Aim

To investigate the long-term risk of thromboembolism and serious bleeding associated with oral anticoagulation (OAC) therapy beyond 3 months after radiofrequency ablation (RFA) of atrial fibrillation (AF).

Methods and results

Linking Danish administrative registries, 4050 patients undergoing fi

mai mult
European Heart Journal - current issue
2 Februarie 2015 10:14
2 Februarie 2015 10:14
Aim

Anticoagulation prophylaxis for stroke is recommended for at-risk patients with either persistent or paroxysmal atrial fibrillation (AF). We compared outcomes in patients with persistent vs. paroxysmal AF receiving oral anticoagulation.

Methods and results

Patients randomized in the Rivaroxaban

mai mult
European Heart Journal - current issue
2 Februarie 2015 10:14
2 Februarie 2015 10:14
2 Februarie 2015 10:14
2 Februarie 2015 10:14
Background

Patients who have both atrial fibrillation (AF) and renal failure have an increased risk of thrombo-embolism. Renal failure is also a risk factor for bleeding, which makes decisions regarding thromboprophylaxis complicated. Our aim was to determine risks for ischaemic stroke and bleeding

mai mult
European Heart Journal - current issue
2 Februarie 2015 10:14
2 Februarie 2015 10:14
2 Februarie 2015 10:14
2 Februarie 2015 10:14
Aims

The pattern of atrial fibrillation (AF) occurrence—paroxysmal, persistent, or permanent—is associated with progressive stages of atrial dysfunction and structural changes and may therefore be associated with progressively higher stroke risk. However, previous studies have not consistently shown

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European Heart Journal - current issue
21 Ianuarie 2015 15:45
21 Ianuarie 2015 15:45
21 Ianuarie 2015 15:45
Aims

An increasing number of clinical studies highlight the importance of the inflammatory mediator prostaglandin F2α (PGF). Prostaglandin F2α activity has been suggested to play pivotal roles in the development of cardiovascular diseases and cancer. However, whether systemic PGF concentrations

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European Heart Journal - current issue
21 Ianuarie 2015 15:45
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