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Jurnale medicale European Journal of Nuclear Medicine and Molecular Imaging (Online First™)

25 Noiembrie 2012 21:39

Abstract
Purpose  
Myocardial perfusion imaging contributes >20 % of the average medical radiation exposure to the population in the USA. Imaging protocols able to achieve a radiation exposure ?9 mSv in 50 % of the studies by 2014 have been recommended. The aim of this study was to analyse the t

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
25 Noiembrie 2012 21:39

Abstract
Purpose  
Radionuclide imaging of insulin-like growth factor type 1 receptor (IGF-1R) expression in tumours might be used for selection of patients who would benefit from IGF-1R-targeted therapy. We have previously shown the feasibility of IGF-1R imaging using the Affibody molecule 111In-

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
25 Noiembrie 2012 21:39

Abstract
Purpose  
Positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) has been used with limited success in the past in primary diagnosis and locoregional staging of urinary bladder cancer, mainly because of the pharmacokinetics of renal excretion of 18F-FDG

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
25 Noiembrie 2012 21:39

Abstract
Purpose  
Prostate-specific membrane antigen (PSMA) is a cell surface protein with high expression in prostate carcinoma (PC) cells. Recently, procedures have been developed to label PSMA ligands with 68Ga, 99mTc and 123/124/131I. Our initial experience with Glu-NH-CO-NH-Lys-(Ahx)-[68Ga(HB

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
19 Noiembrie 2012 15:12

Abstract
Purpose  
Phosphodiesterase 10A (PDE10A) is a cAMP/cGMP-hydrolysing enzyme with a central role in striatal signalling and implicated in neuropsychiatric disorders such as Huntington??s disease, Parkinson??s disease, schizophrenia and addiction. We have developed a novel PDE10A PET ligan

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
19 Noiembrie 2012 15:12

Abstract
Purpose  
Dopamine transporter (DAT) imaging with [123I]FP-CIT (DaTSCAN) is an established diagnostic tool in parkinsonism and dementia. Although qualitative assessment criteria are available, DAT quantification is important for research and for completion of a diagnostic evaluation. One c

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European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
19 Noiembrie 2012 15:12

Reply to comment on Pepe et al.: Somatostatin receptor SPECT

  • Content Type Journal Article
  • Category Letter to the Editor
  • Pages 1-1
  • DOI 10.1007/s00259-012-2283-9
  • Authors
    • Giovanna Pepe, Nuclear Medicine, IRCCS Humanitas, Milan, Italy
    • Arturo Chiti, Nuclear Medicine, IRCCS Humanitas, Milan, Italy
    • Jo
mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
14 Noiembrie 2012 19:02

Abstract
Purpose  
To compare the performance of eight metabolic indices for the early assessment of tumour response in patients with metastatic colorectal cancer (mCRC) treated with chemotherapy.
Methods  
Forty patients with advanced mCRC underwent two FDG PET/CT scans, at baseline and on

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
14 Noiembrie 2012 19:02

Abstract
Purpose  
The active form of vitamin D (1,25(OH)2D) contributes to blood flow regulation in skeletal muscle. The aim of the present study was to determine whether this hormone also modulates coronary physiology, and thus whether abnormalities in its bioavailability contribute to excess car

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
14 Noiembrie 2012 19:02

Abstract
Purpose  
The aim of this study was to evaluate the performance of a novel flat-panel single photon emission computed tomography (SPECT)/CT in patients with suspicion of osteomyelitis (OM) of the jaw in comparison with conventional orthopantomography (OPT), planar bone scintigraphy (PS) a

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
14 Noiembrie 2012 19:02

Abstract
Purpose  
To determine the diagnostic efficacy of 11C-choline PET/CT in patients with prostate cancer (PC) after radical prostatectomy who presented with increasing PSA levels during follow-up in spite of being on hormone treatment (HT), and therefore showing HT resistance.
Method

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European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
14 Noiembrie 2012 19:02

Abstract  
Data available in patients suffering from squamous cell carcinoma of the head and neck, lung carcinoma, oesophageal carcinoma and gynaecological malignancies suggest that metabolic tumour volume and to a lesser extent total lesion glycolysis have the potential to become valuable in the i

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
14 Noiembrie 2012 19:02

Abstract
Purpose  
The purpose of this study was to assess the diagnostic performance of breast-specific gamma imaging (BSGI) as an adjunct modality to mammography for detecting breast cancer.
Methods  
Comprehensive searches of MEDLINE (1984 to August 2012) and EMBASE (1994 to August 2012)

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
14 Noiembrie 2012 19:02

Abstract
Purpose  
The aim of this study was to evaluate the impact of 68Ga-labelled DOTA0-lanreotide (68Ga-DOTA-LAN) on the diagnostic assessment of neuroendocrine tumour (NET) patients with low to moderate uptake on planar somatostatin receptor (SSTR) scintigraphy or 68Ga-labelled DOTA0,Tyr3-octr

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
15 Noiembrie 2012 18:56

Abstract
Purpose  
This study evaluated the potential of functional imaging to monitor disease activity and response to treatment with disease-modifying antirheumatic drugs (DMARD) in DMARD-naive patients with early rheumatoid arthritis (RA).
Methods  
The study involved 17 patients with ac

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European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
15 Noiembrie 2012 18:56

Abstract
Purpose  
The thymidine analog 3??-deoxy-3??-[18F]fluorothymidine (18F-FLT) has been developed as a positron emission tomography (PET) tracer to assess the proliferation activity of tumors in vivo. The present study investigated the relationship between the kinetic parameters of 18F-FLT

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
13 Noiembrie 2012 19:08

EJNMMI: the European way of communicating science

  • Content Type Journal Article
  • Category Editorial
  • Pages 1-3
  • DOI 10.1007/s00259-012-2301-y
  • Authors
    • Ignasi Carri??, Nuclear Medicine Department, Hospital Sant Pau, Barcelona, Spain
mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
13 Noiembrie 2012 19:08

Abstract
Purpose  
A higher prevalence of cardiovascular risk factors (CRFs) in HIV-infected patients, together with chronic infection and treatments, has resulted in an increased risk of silent myocardial ischaemia (SMI). The objective of this study was to evaluate whether myocardial SPECT should

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
10 Noiembrie 2012 10:46

Defining the role for dosimetry and radiobiology in combination therapies

  • Content Type Journal Article
  • Category Editorial Commentary
  • Pages 1-2
  • DOI 10.1007/s00259-012-2281-y
  • Authors
    • Manuel Bardi?s, UMR 1037 INSERM/UPS, Centre de Recherche en Canc??rologie, 133 Route de Narbonne, 31062 Toulouse, Franc
mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
10 Noiembrie 2012 10:46

Abstract
Purpose  
To assess the additional functional vascular information and the relationship between perfusion measurements and glucose metabolism (SUVmax) obtained by including a perfusion CT study in a whole-body contrast-enhanced PET/CT protocol in primary lung cancer lesions.
Meth

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
8 Noiembrie 2012 07:00

Abstract
Purpose  
Stroke induces strong expression of the 72-kDa heat-shock protein (HSP-70) in the ischaemic brain, and neuronal expression of HSP-70 is associated with the ischaemic penumbra. The aim of this study was to image induction of Hsp-70 gene expression in vivo after brain ischaemia us

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
8 Noiembrie 2012 07:00

Abstract
Purpose  
Two allosteric modulators of the group I metabotropic glutamate receptors (mGluR1 and mGluR5) were evaluated as positron emission tomography (PET) radioligands for mGluR1.
Methods  
LY2428703, a full mGluR1 antagonist (IC50 8.9 nM) and partial mGluR5 antagonist (IC50 118 

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
25 Octombrie 2012 06:09

Abstract
Purpose  
To analyse the diagnostic value of 18F-FDG PET and MRI for the evaluation of active lesions in paediatric Langerhans cell histiocytosis.
Methods  
We compared 21 18F-FDG PET scans with 21 MRI scans (mean time interval 17 days) in 15 patients (11 male, 4 female, age range 4

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
25 Octombrie 2012 06:09

Abstract
Purpose  
We investigated whether myocardial 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy predicts impairment of myocardial functional reserve in response to dobutamine stress in patients with idiopathic dilated cardiomyopathy (DCM).
Methods  
Forty DCM patients (LVEF 39?

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
25 Octombrie 2012 06:09

Abstract
Purpose  
Vascular endothelial growth factor receptors (VEGFRs) are associated with tumor growth and induction of tumor angiogenesis and are known to be overexpressed in various human tumors. In the present study, we prepared and evaluated 68Ga-1,4,7-triazacyclononane-1,4,7-triacetic acid-

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
26 Octombrie 2012 12:23

Abstract
Purpose  
Extensive deposition of senile plaques and neurofibrillary tangles in the brain is a pathological hallmark of Alzheimer??s disease (AD). Although several PET imaging agents have been developed for in vivo detection of senile plaques, no PET probe is currently available for sele

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
26 Octombrie 2012 12:23

Abstract
Objective  
When deciding on therapy, FDG PET/CT-positive results should be confirmed by histology if possible. We evaluated the impact of percutaneous PET/CT-guided biopsies on histological confirmation of PET/CT-positive lesions.
Methods  
We prospectively evaluated 126 patients

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
28 Octombrie 2012 12:55

Abstract
Purpose  
Florbetaben is a ?-amyloid-targeted PET tracer with significant potential for augmenting the toolbox in the clinical diagnosis of Alzheimer??s disease (AD). In dementia imaging, shortening of scan duration may simplify future clinical use. The aim of this retrospective study w

mai mult
European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
3 Noiembrie 2012 05:44

Comment on Marciano et. al.: Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease

  • Content Type Journal Article
  • Category Letter to the Editor
  • Pages 1-1
  • DOI 10.1007/s00259-012-2246-1
  • Authors
    • Luca Presotto
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European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
3 Noiembrie 2012 05:44

Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease: reply to Presotto

  • Content Type Journal Article
  • Category Letter to the Editor
  • Pages 1-1
  • DOI 10.1007/s00259-012-2252-3
  • Authors
    • Caterina Marciano, Depa
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European Journal of Nuclear Medicine and Molecular Imaging (Online First™)
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