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Gastroenterologie

Jurnale medicale Gastroenterologie

5 Februarie 2015 12:00
Background: Tofacitinib, a novel, oral Janus kinase inhibitor, demonstrated a dose-dependent efficacy for induction of clinical response and remission in patients with active ulcerative colitis (UC). The objective of the current study was to determine the effect of tofacitinib on patient-reported ou mai mult
BMC Gastroenterology - Latest Articles
5 Februarie 2015 12:00
Background: Colonoscopy offers limited protection against right-sided colon cancer, a significant proportion of which arise from the serrated pathway of carcinogenesis. The aim of this study was to compare cap-assisted colonoscopy and standard high-definition white light colonoscopy regarding serrat mai mult
BMC Gastroenterology - Latest Articles
5 Februarie 2015 12:00
Contributing reviewersThe editors of BMC Gastroenterology would like to thank all our reviewers who have contributed to the journal in Volume 14 (2014). mai mult
BMC Gastroenterology - Latest Articles
5 Februarie 2015 12:00
Background: Cross-sectional imaging techniques as magnetic resonance enterography (MRE) may offer additional information on transmural inflammation, stricturing and fistulising complications in Crohn?s disease (CD). The purpose of our study was to evaluate the diagnostic accuracy of Magnetic Resonan mai mult
BMC Gastroenterology - Latest Articles
5 Februarie 2015
Background: Although poor sleep is common in numerous gastrointestinal diseases, data are scarce on the risk of poor sleep in celiac disease. The objective of this study was to estimate the risk of repeated use of hypnotics among individuals with celiac disease as a proxy measure for poor sleep. Met mai mult
BMC Gastroenterology - Latest Articles
5 Februarie 2015
Background: Intra-tumor heterogeneity is a potential cause for failure of targeted therapy in gastric cancer, but the extent of heterogeneity of established (HER2) or potential (EGFR, CCND1) target genes and prognostic gene alterations (MYC) had not been systematically studied. Methods: To study het mai mult
BMC Gastroenterology - Latest Articles
5 Februarie 2015
Background: Endoscopic biliary stenting (EBS) is one of the most important palliative treatments for biliary tract cancer. However, reflux cholangitis arising from bacterial adherence to the inner wall of the stent must be avoided. We evaluated the use of EBS above the sphincter of Oddi to determine mai mult
BMC Gastroenterology - Latest Articles
5 Februarie 2015
Background: Environmental and genetic factors contribute to variation in irritable bowel syndrome (IBS), anxiety and depression. Comorbidity between these disorders is high. A previous investigation of our population-based twin cohort revealed that low birth weight increased the risk for development mai mult
BMC Gastroenterology - Latest Articles
30 Ianuarie 2015 09:25

Abstract

Background and Aim

To evaluate the role of antiviral therapy with nucleoside analogues (NAs) in sorafenib treated patients with hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC).

Methods

A retrospective cohort study was done in 151 HBV-related HCC patients treated with sora

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Journal of Gastroenterology and Hepatology
3 Februarie 2015 13:40

We appreciate the opportunity to comment on the controversial issues surrounding treatment options for patients with hepatocellular carcinoma. In the field of surgery or interventional radiology it is common to emphasise technical feasibility and early morbidity/mortality rather than medium/long-ter

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Gut current issue
3 Februarie 2015 13:40
Clinical presentation

An 81-year-old man underwent percutaneous mitral valve repair (MitraClip) due to severe symptomatic mitral valve regurgitation. Coronary heart disease was excluded prior to mitral valve repair. Approximately 8 h after the uneventful and successful intervention, the patient pres

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Gut current issue
3 Februarie 2015 13:40
<p>Marlicz and Loniewski<cross-ref type="bib" refid="gutjnl-2014-308107R1">1</cross-ref> offer complementary comments regarding the design and execution of our study of exercise and associated dietary extremes on gut microbial diversity.<cross-ref type="bib" refid="gutjnl-2014-308107R2">2</cross-ref mai mult
Gut current issue
3 Februarie 2015 13:40
Background

Bacteria play a role in the onset and perpetuation of intestinal inflammation in IBD. Compositional alterations may also change the metabolic capacities of the gut bacteria.

Objective

To examine the metabolic activity of the microbiota of patients with Crohn's disease (CD), UC or pouchit

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Gut current issue
3 Februarie 2015 13:40

Dear Editor,

With interest we read the paper by Juste et al1 proposing the amount of zymogen-granule membrane glycoprotein 2 (GP2) on the surface of intestinal bacteria as a Crohn's disease (CD) marker. Indeed, a decreased GP2 level was found on microbes in patients with CD as compared to those of

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Gut current issue
3 Februarie 2015 13:40
Objective

Although paediatric-onset IBD is becoming more common, few medications have a registered paediatric indication. There are multiple hurdles to performing clinical trials in children, emphasising the importance of choosing an appropriate outcome measure, which can facilitate enrolment, and t

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Gut current issue
3 Februarie 2015 13:40

Dear Sir,

We read with interest the article by Habegger et al1 who demonstrated that duodenal nutrient exclusion using duodenal endoluminal sleeve (DES) improves metabolic syndrome and stimulates intestinal villus hyperplasia, especially the bypassed duodenum, in a rodent model of type 2 diabetes m

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Gut current issue
3 Februarie 2015 13:40
Objective

Adherent-invasive Escherichia coli (AIEC) are abnormally predominant on Crohn's disease (CD) ileal mucosa. AIEC strains adhere to enterocytes via interaction between type 1 pili and CEACAM6 receptors abnormally expressed on CD ileal mucosa, leading to gut inflammation. We analysed whether

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Gut current issue
3 Februarie 2015 13:40

MicroRNAs (miRNAs) are small non-coding RNAs, 18–23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miR

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Gut current issue
3 Februarie 2015 13:40
Objective

Understanding the neural circuitry of placebo analgesia in the context of visceral pain is increasingly important given evidence of clinical benefit of placebo treatment in IBS. This functional MRI study addressed placebo analgesia in IBS, UC and healthy control (HC) volunteers.

Design

Pa

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Gut current issue
3 Februarie 2015 13:40
Objective

Although direct-acting antiviral agents (DAAs) have markedly improved the outcome of treatment in chronic HCV infection, there continues to be an unmet medical need for improved therapies in difficult-to-treat patients as well as liver graft infection. Viral entry is a promising target for

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Gut current issue
3 Februarie 2015 13:40
Objective

Intestinal dysbiosis has been associated with coeliac disease (CD), but whether the alterations are cause or consequence of the disease is unknown. This study investigated whether the human leukocyte antigen (HLA)-DQ2 genotype is an independent factor influencing the early gut microbiota c

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Gut current issue
3 Februarie 2015 13:40
Objective

Commensal bacteria and innate immunity play a major role in the development of colorectal cancer (CRC). We propose that selected commensals polarise colon macrophages to produce endogenous mutagens that initiate chromosomal instability (CIN), lead to expression of progenitor and tumour ste

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Gut current issue
3 Februarie 2015 13:40
Objective

To clarify the effectiveness of second-look endoscopy (SLE) at preventing bleeding after gastric endoscopic submucosal dissection (ESD).

Design

A multicentre prospective randomised controlled non-inferiority trial was conducted at five referral institutions across Japan. Patients with a s

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Gut current issue
3 Februarie 2015 13:40

Sir,

We read with great interest the leading article by Bruix et al1 published in Gut. This article recommended palliative treatments for patients with hepatocellular carcinoma (HCC) involving macrovascular invasion, multiple tumours, or portal hypertension.

With better patient selection and improve

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Gut current issue
3 Februarie 2015 13:40
Background

Epigenetic alterations accumulate in normal-appearing tissues of patients with cancer, producing an epigenetic field defect. Cross-sectional studies show that the degree of the defect may be associated with risk in some types of cancer, especially cancers associated with chronic inflammat

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Gut current issue
3 Februarie 2015 13:40

Dear Sir,

I read with interest the study by Steenholdt et al1 which concluded that individualised infliximab therapy was more cost effective compared with empirical dose escalation in Crohn's disease (CD) patients who developed secondary non-response to infliximab.

The study methodology has a number

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Gut current issue
3 Februarie 2015 13:40
Objective

The two major histological types of oesophageal cancer—adenocarcinoma (AC) and squamous cell carcinoma (SCC)—are known to differ greatly in terms of risk factors and epidemiology. To date, global incidence estimates for individual subtypes are still lacking. This study for the first time q

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Gut current issue
3 Februarie 2015 13:40
Objective

To elucidate the association between antiviral therapy and extrahepatic outcomes in individuals infected with HCV.

Methods

This nationwide cohort study screened 293 480 Taiwanese residents with HCV infection and excluded those with substantial comorbidity. A total of 12 384 eligible patie

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Gut current issue
3 Februarie 2015 13:40
Objective

Current diagnostic methods for gastro-oesophageal reflux disease (GORD) have moderate sensitivity/specificity and can be invasive and expensive. Pepsin detection in saliva has been proposed as an ‘office-based’ method for GORD diagnosis. The aims of this study were to establish normal valu

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Gut current issue
3 Februarie 2015 13:40

GORD has been defined by international consensus based on symptoms of heartburn and regurgitation.1 While this definition is useful for patients with the typical reflux syndrome, these symptoms may not be present in patients with extra-oesophageal GORD. The limitations of pH testing and endoscopy we

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Gut current issue
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