Home Jurnale medicale Journal of Hematology & Oncology - Latest Articles
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Jurnale medicale Journal of Hematology & Oncology - Latest Articles

24 Decembrie 2014
Background: Although distinct patterns of homeobox (HOX) gene expression have been described in defined cytogenetic and molecular subsets of patients with acute myeloid leukemia (AML), it is unknown whether these patterns are the direct result of transcriptional alterations or rather represent the d mai mult
Journal of Hematology & Oncology - Latest Articles
19 Decembrie 2014 12:00
Background: Most patients with small cell lung cancer (SCLC) or neuroblastoma (NB) already show clinically detectable metastases at diagnosis and have an extremely poor prognosis even when treated with combined modalities. The HuD-antigen is a neuronal RNA-binding protein that is expressed in 100% o mai mult
Journal of Hematology & Oncology - Latest Articles
12 Decembrie 2014 12:00
According to the 2008 World Health Organization classification, chronic neutrophilic leukemia, chronic myelomonocytic leukemia and atypical chronic myeloid leukemia are rare diseases. The remarkable progress in our understanding of the molecular genetics of myeloproliferative neoplasms and myelodysp mai mult
Journal of Hematology & Oncology - Latest Articles
14 Decembrie 2014 12:00
We characterized bone marrow stromal cells (BMSC) from patients with pre-fibrotic myeloproliferative neoplasms (MPN). MPN-BMSC showed decreased capacity to stimulate the proliferation of colony-forming units of normal hematopoietic stem and progenitor cells and displayed increased matrix remodelling mai mult
Journal of Hematology & Oncology - Latest Articles
10 Decembrie 2014 12:00
Long non-coding RNAs (lncRNAs) govern fundamental biochemical and cellular processes. lncRNA HOX transcript antisense RNA (HOTAIR) represses gene expression through recruitment of chromatin modifiers. The expression of HOTAIR is elevated in lung cancer and correlates with metastasis and poor prognos mai mult
Journal of Hematology & Oncology - Latest Articles
10 Decembrie 2014 12:00
The proviral insertion in murine (PIM) lymphoma proteins are a serine/threonine kinase family composed of three isoformes: Pim-1, Pim-2 and Pim-3. They play a critical role in the control of cell proliferation, survival, homing and migration. Recently, overexpression of Pim kinases has been reported mai mult
Journal of Hematology & Oncology - Latest Articles
7 Decembrie 2014 12:00
Background: The presence of somatic mutations in splicing factor 3b subunit 1 (SF3B1) in patients with Myelodysplastic syndromes with ring sideroblasts (MDS-RS) highlights the importance of the RNA-splicing machinery in MDS. We previously reported the presence of bone marrow (BM) RS in Sf3b1 heteroz mai mult
Journal of Hematology & Oncology - Latest Articles
5 Decembrie 2014 12:00
Shuttling of specific proteins out of the nucleus is essential for the regulation of the cell cycle and proliferation of both normal and malignant tissues. Dysregulation of this fundamental process may affect many other important cellular processes such as tumor growth, inflammatory response, cell c mai mult
Journal of Hematology & Oncology - Latest Articles
5 Decembrie 2014 12:00
Through epithelial-mesenchymal transition (EMT), cancer cells acquire enhanced ability of migration and invasion, stem cell like characteristics and therapeutic resistance. Notch signaling regulates cell-cell connection, cell polarity and motility during organ development. Recent studies demonstrate mai mult
Journal of Hematology & Oncology - Latest Articles
5 Decembrie 2014 12:00
Background: Peripheral T-cell lymphomas (PTCLs) are often aggressive tumors and resistant to conventional chemotherapy. Dysregulation of extrinsic apoptosis plays an important role on tumor cell sensitivity to chemotherapeutic agents. Cellular FLICE inhibitory protein (c-FLIP) is a key regulator of mai mult
Journal of Hematology & Oncology - Latest Articles
5 Decembrie 2014 12:00
Since the discovery of circulating microRNAs (miRNAs) in body fluids, an increasing number of studies have focused on their potential as non-invasive biomarkers and as therapeutic targets or tools for many diseases, particularly for cancers. Because of their stability, miRNAs are easily detectable i mai mult
Journal of Hematology & Oncology - Latest Articles
30 Noiembrie 2014 12:00
While microRNAs (miRNAs) and the KRAS oncogene are known to be dysregulated in various cancers, little is known about the role of miRNAs in the regulation of KRAS in cancer. Here we review a selection of studies published in 2014 that have contributed to our understanding of the molecular mechanisms mai mult
Journal of Hematology & Oncology - Latest Articles
25 Noiembrie 2014 12:00
Dysregulation of microRNA networks has been implicated in hematological malignancies. One of the reasons for disturbed miRNA-mediated regulation are polymorphisms in miRNA-binding sites (miRSNPs), which alter the strength of miRNA interaction with target transcripts. In the recent years the first fi mai mult
Journal of Hematology & Oncology - Latest Articles
13 Noiembrie 2014 12:00
Recent identification of synthetic lethal interactions involving several proteins of the SWI/SNF complex discussed in this Research Highlight has opened the possibility of new cancer therapeutic approaches. mai mult
Journal of Hematology & Oncology - Latest Articles
31 Octombrie 2014 12:00
Endothelial dysfunction is a pathological status of the vascular system, which can be broadly defined as an imbalance between endothelium-dependent vasoconstriction and vasodilation. Endothelial dysfunction is a key event in the progression of many pathological processes including atherosclerosis, t mai mult
Journal of Hematology & Oncology - Latest Articles
7 Noiembrie 2014 12:00
Here, we report and investigate the genomic alterations of two novel cases of Non-Hodgkin Lymphoma (NHL) in children with Williams-Beuren syndrome (WBS), a multisystem disorder caused by 7q11.23 hemizygous deletion. Additionally, we report the case of a child with NHL and a somatic 7q11.23 deletion. mai mult
Journal of Hematology & Oncology - Latest Articles
4 Noiembrie 2014 12:00
Background: Leukemia is a systemic malignancy originated from hematopoietic cells. The extracellular environment has great impacts on the survival, proliferation and dissemination of leukemia cells. The spleen is an important organ for extramedullary hematopoiesis and a common infiltration site in l mai mult
Journal of Hematology & Oncology - Latest Articles
23 Octombrie 2014 12:00
Recently it was reported that microRNA from the miR-17??~??92 family may have a key role in chronic lymphocytic leukemia (CLL). Here, we designed specific oligonucleotides to target endogenous miR-17 (antagomiR17). In-vitro administration of antagomiR17 effectively reduced miR-17 expression and th mai mult
Journal of Hematology & Oncology - Latest Articles
17 Octombrie 2014
Background: Renal cell carcinoma (RCC) is a complex with diverse biological characteristics and distinct molecular signature. New target therapies to molecules that drive RCC initiation and progression have achieved promising responses in some patients, but the total effective rate is still far from mai mult
Journal of Hematology & Oncology - Latest Articles
15 Octombrie 2014 12:00
The WHO 2008 definition of chronic neutrophilic leukemia (CNL) is based on clinical and laboratory parameters but not on molecular abnormalities. Mutations in CSF3R, SETBP1 and CALR are reported in patients with chronic neutrophilic leukemia (CNL). However, because CNL is rare, there are few large s mai mult
Journal of Hematology & Oncology - Latest Articles
15 Octombrie 2014 12:00
Dysregulation of the nucleo-cytoplasmic transport of proteins plays an important role in carcinogenesis. The nuclear export of proteins depends on the activity of transport proteins, exportins. Exportins belong to the karyopherin ? superfamily. Exportin-1 (XPO1), also known as chromosomal region ma mai mult
Journal of Hematology & Oncology - Latest Articles
10 Octombrie 2014 12:00
Background: The identification of fusion genes such as SYT-SSX1/SSX2, PAX3-FOXO1, TPM3/TPM4-ALK and EWS-FLI1 in human sarcomas has provided important insight into the diagnosis and targeted therapy of sarcomas. No recurrent fusion has been reported in human osteosarcoma. Methods: Transcriptome seque mai mult
Journal of Hematology & Oncology - Latest Articles
30 Septembrie 2014 12:00
Background: Studying DNA methylation changes in the context of structural rearrangements and point mutations as well as gene expression changes enables the identification of genes that are important for disease onset and progression in different subtypes of acute myeloid leukemia (AML) patients. The mai mult
Journal of Hematology & Oncology - Latest Articles
1 Octombrie 2014 12:00
Background: It has recently been reported that the extracts of green tea polyphenol have cancer preventive effects. In this study, we investigated the effect of the natural composition from green tea leaves Catechins on acute promyelocytic leukemia (APL). Methods: In vitro, APL cell lines NB4, retin mai mult
Journal of Hematology & Oncology - Latest Articles
2 Octombrie 2014
Immune thrombocytopenia is an autoimmune disease with abnormal T cell immunity. Cytotoxic T cells, abnormal T regulatory cells, helper T cell imbalance, megakaryocyte maturation abnormalities and abnormal T cell anergy are involved in the pathogenesis of this condition. The loss of T cell-mediated i mai mult
Journal of Hematology & Oncology - Latest Articles
3 Octombrie 2014 12:00
Technological advancements in the molecular characterization of cancers have enabled researchers to identify an increasing number of key molecular drivers of cancer progression. These discoveries have led to multiple novel anticancer therapeutics, and clinical benefit in selected patient populations mai mult
Journal of Hematology & Oncology - Latest Articles
4 Octombrie 2014 12:00
Background: De novo acute myeloid leukemia (AML) with concurrent DNMT3A, FLT3 and NPM1 mutations (AML DNMT3A/FLT3/NPM1 ) has been suggested to represent a unique AML subset on the basis of integrative genomic analysis, but the clinical features of such patien mai mult
Journal of Hematology & Oncology - Latest Articles
4 Octombrie 2014 12:00
Regulation of protein trafficking between the nucleus and cytoplasm represents a novel control point for antineoplastic intervention. Several proteins involved with cellular growth and survival depend on precise and timely positioning within the cell to fulfill their functions, and the nuclear membr mai mult
Journal of Hematology & Oncology - Latest Articles
5 Octombrie 2014
Background: Exportin 1 (XPO1), also called chromosome region maintenance 1 (CRM1), is the sole exportin mediating transport of many multiple tumor suppressor proteins out of the nucleus.Aim and methods: To verify the hypothesis that XPO1 inhibition affects prostate cancer (PCa) metastatic potential, mai mult
Journal of Hematology & Oncology - Latest Articles
27 Septembrie 2014 12:00
Background: Head and neck squamous cell carcinoma (HNSCC) mortality rates have not shown significant reduction in decades. Platelets are being implicated in having cancer-promoting roles, an observation supported by the adverse outcomes in many malignancies associated with thrombocytosis. However, t mai mult
Journal of Hematology & Oncology - Latest Articles
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