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Jurnale medicale
Medicina interna

Jurnale medicale Medicina interna

1 Februarie 2015 22:00
Chronic heart failure (CHF) is a major cause of morbidity and mortality, and cardiac cachexia and sarcopenia are serious complications associated with weight loss and increased catabolism. Fat-free mass index (FFMI) is an indicator of resting energy expenditure and is used for the clinical diagnosis mai mult
European Journal of Internal Medicine
29 Ianuarie 2015 21:00

Oxidative stress has long been implicated in cardiovascular disease, but more recently, the role of reactive oxygen species (ROS) in normal physiological signaling has been elucidated. Signaling pathways modulated by ROS are complex and compartmentalized, and we are only beginning to identify the mo

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
Rationale:

To maintain cardiac mechanical and structural integrity after an ischemic insult, profound alterations occur within the extracellular matrix. Osteoglycin is a small leucine-rich proteoglycan previously described as a marker of cardiac hypertrophy.

Objective:

To establish whether osteogly

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00

Autophagy is an important physiological process in the heart, and alterations in autophagic activity can exacerbate or mitigate injury during various pathological processes. Methods to assess autophagy have changed rapidly because the field of research has expanded. As with any new field, methods an

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
Rationale:

A major goal for the treatment of heart tissue damaged by cardiac injury is to develop strategies for restoring healthy heart muscle through the regeneration and repair of damaged myocardium. We recently demonstrated that administration of a specific combination of microRNAs (miR combo) i

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00

There is increasing interest in the role of autophagic flux in maintaining normal vessel wall biology and a growing suspicion that autophagic dysregulation may be a common pathway through which vascular aging and associated pathologies develop. Within endothelial and smooth muscle cells, diverse but

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
Rationale:

The mechanisms leading to an expanded neutrophil and monocyte supply after stroke are incompletely understood.

Objective:

To test the hypothesis that transient middle cerebral artery occlusion (tMCAO) in mice leads to activation of hematopoietic bone marrow stem cells.

Methods and Resul mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00

Autophagy is a catabolic recycling pathway triggered by various intra- or extracellular stimuli that is conserved from yeast to mammals. During autophagy, diverse cytosolic constituents are enveloped by double-membrane vesicles, autophagosomes, which later fuse with lysosomes or the vacuole to degra

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
Rationale:

Proper patterning of the atrioventricular canal (AVC) is essential for delay of electrical impulses between atria and ventricles, and defects in AVC maturation can result in congenital heart disease.

Objective:

To determine the role of canonical Wnt signaling in the myocardium during AVC

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
Rationale:

Preclinical evidence demonstrates that inorganic nitrite, after its in situ conversion to nitric oxide, attenuates consequent myocardial reperfusion injury.

Objective:

We investigated whether intracoronary injection of nitrite during primary percutaneous coronary intervention might impro

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
29 Ianuarie 2015 21:00

Coronary artery disease causes acute myocardial infarction and heart failure. Identifying coronary vascular progenitors and their developmental program could inspire novel regenerative treatments for cardiac diseases. The developmental origins of the coronary vessels have been shrouded in mystery an

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
29 Ianuarie 2015 21:00

Autophagy is a reparative, life-sustaining process by which cytoplasmic components are sequestered in double-membrane vesicles and degraded on fusion with lysosomal compartments. Growing evidence reveals that basal autophagy is an essential in vivo process mediating proper vascular function. Moreove

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
29 Ianuarie 2015 21:00
29 Ianuarie 2015 21:00
29 Ianuarie 2015 21:00
Rationale:

Trimethylamine-N-oxide (TMAO), a gut microbial-dependent metabolite of dietary choline, phosphatidylcholine (lecithin), and l-carnitine, is elevated in chronic kidney diseases (CKD) and associated with coronary artery disease pathogenesis.

Objective:

To both investigate the clinical pro

mai mult
Circulation Research current issue
29 Ianuarie 2015 21:00
29 Ianuarie 2015 21:00

Autophagy is an evolutionarily conserved process by which long-lived proteins and organelles are sequestered by autophagosomes and subsequently degraded by lysosomes for recycling. Autophagy is important for maintaining cardiac homeostasis and is a survival mechanism that is upregulated during stres

mai mult
Circulation Research current issue
2 Februarie 2015 21:00
2 Februarie 2015 21:00
Background—

Many young adults with moderate hyperlipidemia do not meet statin treatment criteria under the new American Heart Association/American College of Cardiology cholesterol guidelines because they focus on 10-year cardiovascular risk. We evaluated the association between years of exposure to

mai mult
Circulation current issue
2 Februarie 2015 21:00
2 Februarie 2015 21:00
2 Februarie 2015 21:00
Background—

Temporary interruption of oral anticoagulation for procedures is often required, and some propose using bridging anticoagulation. However, the use and outcomes of bridging during oral anticoagulation interruptions in clinical practice are unknown.

Methods and Results—

The Outcomes Regis

mai mult
Circulation current issue
2 Februarie 2015 21:00
2 Februarie 2015 21:00
Background—

This study sought to evaluate the prevalence of previously undiagnosed arrhythmias in candidates for transcatheter aortic valve replacement (TAVR) and to determine the impact on therapy changes and arrhythmic events after the procedure.

Methods and Results—

A total of 435 candidates for

mai mult
Circulation current issue
2 Februarie 2015 21:00
2 Februarie 2015 21:00
2 Februarie 2015 21:00
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