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Jurnale medicale
Nefrologie

Jurnale medicale Nefrologie

6 Februarie 2015 08:02

Abstract

Aim

This study evaluated the safety and efficacy of influenza vaccination in patients with anti-neutrophil cytoplasmic antibody associated vasculitis.

Methods

31 patients who were in remission were randomised to receive either a trivalent influenza vaccine or no vaccine. Vaccine efficacy was

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Nephrology
4 Februarie 2015 08:32

Abstract

Aim

Hyperuricemia is a common finding in subjects with life-style related diseases. This study was performed to examine its association with chronic kidney disease in relation to other risk factors in a community-based population.

Methods

Data from 187,914 participants, excepting chronic kidn

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Nephrology
30 Ianuarie 2015 08:58

Abstract

Background

Whether socioeconomic status confers worse outcomes after kidney transplantation is unknown. Its influence on allograft and patient survival following kidney transplantation in Ireland was examined.

Methods

A retrospective, observational cohort study of adult deceased-donor first k

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Nephrology
3 Februarie 2015 09:06

Abstract

Background

Coagulation abnormalities, endothelial dysfunction and arteriosclerosis play a key role in cardiovascular disease state observed in transplanted patients. Plasma adiponectin levels are lower following kidney transplantation. However, there is still a debate about this topic in the

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Nephrology
3 Februarie 2015 09:06

Abstract

Background

Congenital anomalies of the kidneys and urinary tract (CAKUT) comprise various entities of structural malformations that result from defects in morphogenesis of the kidney and/or urinary tract. These anomalies are the most common diagnosed malformations in the prenatal period and

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Nephrology
30 Ianuarie 2015 18:01

Although APOL1 gene variants are associated with nephropathy in African Americans, little is known about APOL1 protein synthesis, uptake, and localization in kidney cells. To address these questions, we examined APOL1 protein and mRNA localization in human kidney and human kidney-derived cell lines.

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01
30 Ianuarie 2015 18:01

Hyperglycemia results in increased oxygen consumption and decreased oxygen tension in the kidney. We tested the hypothesis that activation of hypoxia-inducible factors (HIFs) protects against diabetes-induced alterations in oxygen metabolism and kidney function. Experimental groups consisted of cont

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01
30 Ianuarie 2015 18:01
30 Ianuarie 2015 18:01
30 Ianuarie 2015 18:01

African Americans are at increased risk for cardiovascular and metabolic diseases, including obesity, high BP, diabetes, CKD, myocardial infarction, and stroke. Here we summarize the current risks and provide an overview of the underlying risk factors that may account for these associations. By revi

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01

Loss of podocytes underlies progression of CKD. Detachment of podocytes from the glomerular basement membrane (GBM) rather than apoptosis or necrosis seems to be the major mechanism of podocyte loss. Such detachment of viable podocytes may be caused by increased mechanical distending and shear force

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01
30 Ianuarie 2015 18:01

Anion exchanger-1 (AE1) mediates chloride-bicarbonate exchange across the plasma membranes of erythrocytes and, via a slightly shorter transcript, kidney epithelial cells. On an omnivorous human diet, kidney AE1 is mainly active basolaterally in α-intercalated cells of the collecting duct, where it

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01

Indoxyl sulfate and p-cresol sulfate have been suggested to induce kidney tissue remodeling. This study aimed to clarify the molecular mechanisms underlying this tissue remodeling using cultured human proximal renal tubular cells and half-nephrectomized mice treated with indoxyl sulfate or p-cresol

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01

A noninvasive means to predict the onset and recurrence of lupus nephritis (LN) before overt renal injury is needed to optimize and individualize treatment. Colony-stimulating factor-1 (CSF-1) is expressed by kidney tubules at the onset of LN, increases with disease progression, and spills into the

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01

A variety of genetic backgrounds cause the loss of function of thiazide-sensitive sodium chloride cotransporter, encoded by SLC12A3, responsible for the phenotypes in Gitelman syndrome. Recently, the phenomenon of exon skipping, in which exonic mutations result in abnormal splicing, has been associa

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01

Conventional markers of macrophages (Mfes) and dendritic cells (DCs) lack specificity and often overlap, leading to confusion and controversy regarding the precise function of these cells in kidney and other diseases. This study aimed to identify the phenotype and function of renal mononuclear phago

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01

Podocytes are critically involved in the maintenance of the glomerular filtration barrier and are key targets of injury in many glomerular diseases. Chronic injury leads to progressive loss of podocytes, glomerulosclerosis, and renal failure. Thus, it is essential to maintain podocyte survival and a

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01

Proteinase 3 (PR3) and myeloperoxidase (MPO) are two major autoantigens in patients with vasculitis with ANCA. The genes encoding these autoantigens are abnormally expressed in peripheral granulocytes of patients with active ANCA-associated vasculitis. This study provides evidence that this transcri

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01

Phospholipase A2 receptor 1 (PLA2R) is a target autoantigen in 70% of patients with idiopathic membranous nephropathy. We describe the location of a major epitope in the N-terminal cysteine-rich ricin domain of PLA2R that is recognized by 90% of human anti-PLA2R autoantibodies. The epitope was sensi

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01

Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults. Recent clinical studies established that >70% of patients with idiopathic (also called primary) MN (IMN) possess circulating autoantibodies targeting the M-type phospholipase A2 receptor-1 (PLA2R) on the surface of glomer

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01

AKI is associated with increased morbidity, mortality, and cost of care, and therapeutic options remain limited. Reactive oxygen species are critical for the genesis of ischemic AKI. Stanniocalcin-1 (STC1) suppresses superoxide generation through induction of uncoupling proteins (UCPs), and transgen

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01

Whether inclusion of the coronary artery calcium score improves cardiovascular risk prediction in individuals with CKD, a population with unique calcium-phosphate homeostasis, is unknown. Among 6553 participants ages 45–84 years without prior cardiovascular disease in the Multi-Ethnic Study of Ather

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01

ANCA-activated phagocytes cause vasculitis and necrotizing crescentic GN (NCGN). ANCA-induced phagocyte NADPH oxidase (Phox) may contribute by generating tissue-damaging reactive oxygen species. We tested an alternative hypothesis, in which Phox restrains inflammation by downregulating caspase-1, th

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01

Aldosterone-independent mechanisms may contribute to K+ homeostasis. We studied aldosterone synthase knockout (AS–/–) mice to define renal control mechanisms of K+ homeostasis in complete aldosterone deficiency. AS–/– mice were normokalemic and tolerated a physiologic dietary K+ load (2% K+, 2 days)

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01

Patients with Gitelman syndrome (GS), an inherited salt-losing tubulopathy, are usually treated with potassium-sparing diuretics or nonsteroidal anti-inflammatory drugs and oral potassium and magnesium supplementations. However, evidence supporting these treatment options is limited to case series s

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01

Arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis (HD). However, many AVFs fail before starting dialysis. To assess the optimal time for AVF placement in the elderly, we linked data from the US Renal Data System with Medicare claims data to identify 17,511 patients≥67 yea

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Journal of the American Society of Nephrology current issue
30 Ianuarie 2015 18:01

Antibody-mediated rejection (AMR) is a major cause of kidney graft loss, yet assessment of individual risk at diagnosis is impeded by the lack of a reliable prognosis assay. Here, we tested whether the capacity of anti-HLA antibodies to bind complement components allows accurate risk stratification

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Journal of the American Society of Nephrology current issue
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