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Jurnale medicale Nephrology Dialysis Transplantation - current issue

28 Ianuarie 2015 15:07
28 Ianuarie 2015 15:07
Background

There have been few studies of earlier systematic intervention to reduce the impact of acute kidney injury (AKI). In 2009, we piloted an AKI outreach service with a before and after study, and we report on the study and its longer-term follow-up.

Methods

AKI patients were identified usin

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Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07

In the kidney transplant population with atrial fibrillation (AF), evidence regarding the effectiveness and safety of warfarin treatment is lacking. We used fee-for-service Medicare claims to identify kidney transplant recipients with newly diagnosed AF from the United States Renal Data System. Warf

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Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07
Background

Galactose-deficient O-glycans in the hinge region (HR) of immunoglobulin A1 (IgA1) play a key role in the pathogenesis of IgA nephropathy (IgAN). O-Glycans of circulatory IgA1 consist of N-acetylgalactosamine (GalNAc) with a β1,3-linked galactose; both sugars may be sialylated. In patients

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Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07
Background

The likelihood of peritoneal dialysis (PD) utilization following a PD catheter insertion attempt is poorly described. We explored the risk factors for PD nonuse, focusing on the method of PD catheter implantation.

Methods

This population-based retrospective cohort study employed Ontario

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Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07
Background

αKlotho is the prototypic member of the Klotho family and is most highly expressed in the kidney. αKlotho has pleiotropic biologic effects, and in the kidney, its actions include regulation of ion transport, cytoprotection, anti-oxidation and anti-fibrosis. In rodent models of chronic kid

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Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07
Background

Sclerostin is a Wnt pathway antagonist regulating osteoblast activity and bone turnover, and it plays a role in cardiovascular calcification processes. Previous findings indicate that sclerostin regulation is disturbed in chronic kidney disease (CKD). The aim of this study was to assess t

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Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07

In this position article, DESCARTES (Developing Education Science and Care for Renal Transplantation in European States) board members describe the current strategies aimed at expanding living and deceased donor kidney pools. The article focuses on the recent progress in desensitization and kidney p

mai mult
Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07
Background

Obese sarcopenia characterized by increased fat mass and protein-energy wasting (PEW) is not uncommon in chronic kidney disease (CKD) stage 5 patients in whom it is associated with worse outcomes. Serum hepatocyte growth factor (HGF) is associated with obesity in the general population an

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Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07

BK virus, first isolated in 1971, is a significant risk factor for renal transplant dysfunction and allograft loss. Unfortunately, treatment options for BK virus infection are limited, and there is no effective prophylaxis. Although overimmunosuppression remains the primary risk factor for BK infect

mai mult
Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07
Background

The progression of diabetic nephropathy (DN) is frequently determined by clinical parameters; however, the predictive value of histologic lesions remains largely unknown. Our aim was to evaluate the relationship between histologic changes and renal outcome in patients with type 2 diabetes

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Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07
28 Ianuarie 2015 15:07
Background

Puumala virus (PUUV) is the most common species of hantavirus in Central Europe. Nephropathia epidemica (NE), caused by PUUV, is characterized by acute kidney injury (AKI) and thrombocytopenia. The major goals of this study were to provide a clear clinical phenotyping of AKI in patients w

mai mult
Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder and is known to affect all ethnic groups with a prevalence of 1:400–1:1000 live births. The kidney in ADKPD is characterized by the formation of numerous cysts which progressively expand and eventually

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Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07

Mutations in the UMOD gene coding for uromodulin cause autosomal dominant tubulointerstitial kidney disease. Uromodulin is known to regulate transport processes in the thick ascending limb, but it remains unknown whether UMOD mutations are associated with functional tubular alterations in the early

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Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07

The management of anemia in patients with chronic kidney disease (CKD) is difficult. The availability of erythropoiesis-stimulating agents (ESAs) has increased treatment options for previously transfusion-requiring patients, but the recent evidence of ESA side effects has prompted the search for com

mai mult
Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07
Background

Haemodiafiltration (HDF), by successfully removing the larger solutes and protein-bound compounds, may offer a feasible approach to improve dialysis outcomes. Recently, three large, randomized, controlled trials have tested this hypothesis, but only one showed an improved survival associa

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Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07

Fluid management has been a vital part of routine clinical care for more than 180 years. The increasing number of available fluids has generated controversy about the optimal choice of resuscitation fluid. In this review, we provide a critical overview of the different fluids available, their compos

mai mult
Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07
Background

Chronic systemic inflammation is common in patients with chronic kidney disease on dialysis (CKD5D) and has been considered a key mediator of the increased cardiovascular risk in this patient population. In this study, we tested the hypothesis that supplementation of omega-3 polyunsaturat

mai mult
Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07

Despite identification of several cellular mechanisms being thought to underlie the development of septic acute kidney injury (AKI), the pathophysiology of the occurrence of AKI is still poorly understood. It is clear, however, that instead of a single mechanism being responsible for its aetiology,

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Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07
28 Ianuarie 2015 15:07

Phosphorus is an essential element for life but is a rare element in the universe. On Earth, it occurs mostly in the form of phosphates that are widespread but predominantly at very low concentration. This relative rarity has resulted in a survival advantage, in evolutionary terms, to organisms that

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Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07
Background

Recent studies have shown an increasing risk of hypothyroidism with incrementally lower estimated glomerular filtration rate (eGFR) in cohorts comprised of patients with normal to mildly impaired kidney function. We sought to confirm these findings in a nationally representative cohort of

mai mult
Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07
28 Ianuarie 2015 15:07
Background

Diabetes is the leading cause of end-stage kidney disease (ESKD). Because of conflicting results in observational studies, it is still subject to debate whether in diabetic patients the dialysis modality selected as first treatment (haemodialysis or peritoneal dialysis) may have a major i

mai mult
Nephrology Dialysis Transplantation - current issue
28 Ianuarie 2015 15:07
28 Ianuarie 2015 15:07
Background

Serum sodium is commonly measured by direct potentiometry (DNa), in blood gas panels, or indirect potentiometry (INa), in metabolic panels run on chemistry analyzers. Abnormal values of the serum non-water fraction interfere with INa, with low values causing pseudohypernatremia (INa > DNa

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Nephrology Dialysis Transplantation - current issue
8 Ianuarie 2015 00:04
Background

The obective of this study was to perform a cost-effectiveness analysis comparing intermittent with continuous renal replacement therapy (IRRT versus CRRT) as initial therapy for acute kidney injury (AKI) in the intensive care unit (ICU).

Methods

Assuming some patients would potentially

mai mult
Nephrology Dialysis Transplantation - current issue
8 Ianuarie 2015 00:04
Background

The mTOR pathway, which consists of mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), is activated in polycystic kidney disease (PKD) kidneys. Sirolimus and everolimus indirectly bind and inhibit mTORC1. A novel group of drugs, the mTOR kinase inhibitors, directly bind to mTOR kinase,

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Nephrology Dialysis Transplantation - current issue
8 Ianuarie 2015 00:04
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