Jurnale medicale Neuropsihiatrie
Lymphomatosis cerebri (LC) is a rare variant of primary central nervous system lymphoma (PCNSL) pathologically characterised by diffuse cerebral infiltration of a non-cohesive mass of malignant lymphoid cells. We describe a case of rapidly progressive dementia where MRI demonstrated a d
There is less data available regarding the characteristics of cognitive impairment in patients with amyotrophic lateral sclerosis (ALS) in a population-based series.
Patients with ALS incident in Piemonte, Italy, between 2009 and 2011 underwent an extensive neuropsychological
A 46-year-old woman from Brazil complained about increasing headaches for 2 weeks. On admission, she presented with neck rigidity and disorientation. The cranial MRI was unremarkable (
Since liver transplant (LT) was introduced to treat patients with familial amyloid polyneuropathy carrying the V30M mutation (ATTR-V30M), ocular and cardiac complications have developed. Long-term central nervous system (CNS) involvement was not investigated. Our goals were to: (1) identi
The association between intracranial pressure (ICP) and different shunt valve opening pressures in relation to body positions is fundamental for understanding the physiological function of the shunt.
To analyse the ICP and ICP wave amplitude (AMP) at different shunt settings an
Limited data are available on radiation-induced myopathy (RIM) in adult cancer survivors.
We retrospectively reviewed the clinical, electrophysiological, serological, radiological and pathological findings of patients with RIM seen in the neurology clinic over a 11-year period (2
Alemtuzumab is a newly licensed treatment of active relapsing-remitting multiple sclerosis (RRMS) in Europe, which in phase II and III studies demonstrated superior efficacy over β-interferon in reducing disability progression over 2–3 years. In this observational cohort study, we sought
Reduced deactivation within the default mode network (DMN) is common in individuals with primary affective disorders relative to healthy volunteers (HVs). It is unknown whether similar network abnormalities are present in temporal lobe epilepsy (TLE) patients with a history of affective ps
In 1908, Oluf Bang and Vilhelm Ellerman laid the foundation for theory of oncoviruses by demonstrating that the avian erythroblastosis (a form of chicken leukaemia) could be transmitted by cell-free extracts. Since then, it has been shown very convincingly that viruses can directly cause several hummai mult Journal of Neurology, Neurosurgery & Psychiatry current issue
Recently, several large randomised controlled trials about the treatments of cognitive impairment or dementia due to Parkinson's disease (CIND-PD or PDD) and dementia with Lewy bodies (DLB) were completed. Here, we systematically reviewed the studies (including the recent reports) to provi
Simple, robust, sensitive and clinically meaningful outcome measures are required for neuroprotective trials in Parkinson's disease (PD). We explored the feasibility of a composite binary outcome measure, ‘dead or dependent’, in such trials using data from a prospective follow-up study of
We aimed to examine the association of apolipoprotein E (APOE) 4 genotype with neuroimaging markers of Alzheimer's disease: hippocampal volume, brain amyloid deposition and cerebral metabolism.
We performed a systematic review and meta-analysis of 14 cross-sectional studies identi
It is an exciting time to be involved in the treatment of multiple sclerosis (MS). While the exact cause still remains elusive, over the last decade there have been a plethora of new treatments and approaches: disease modifying and symptomatic. This third edition therefore comes at exactly the rightmai mult Journal of Neurology, Neurosurgery & Psychiatry current issue
In the recent paper by Farahmand et al
This review argues that even with the tremendous advances in diagnostic neuroimaging that the clinical skills involved in clinical neurology (ie, history, examination, localisation and differential diagnosis) remain key. Yet a number of recent audits suggest that large numbers of patients are failinmai mult Journal of Neurology, Neurosurgery & Psychiatry current issue
The highest standards of clinical evidence are phase III randomised, double-blind, controlled clinical trials. Their significance to clinical medicine is given theoretically by the fact that patients as well as doctors are blind to the treatment and no bias can subvert patients’ assignments to eithemai mult Journal of Neurology, Neurosurgery & Psychiatry current issue
Altered reactivity of peripheral blood mononuclear cells (PBMC) and their production of cytokines may affect multiple sclerosis (MS) clinical course. We assessed the relationship of stimulated PBMC-produced IFN-, TNF-α, IL-4 and IL-10 in modulating relapse risk using a prospective cohort
Liver transplantation is a well-established treatment for transthyretin (TTR)-type familial amyloid polyneuropathy (TTR-FAP).
To assess the frequency of symptoms of impulse control disorders (ICD, namely pathological gambling, compulsive sexual behaviour, compulsive eating and compulsive shopping) and related behaviours (hobbyism, punding, walkabout and dopamine dysregulation syndrome) in patients with Parkinson'
Nicholl and Appleton
Giant cell arteritis (GCA) is the most common vasculitis in people ≥50 years and can be associated with stroke. We aimed to evaluate the epidemiology and characteristics of stroke in patients with GCA.
All patients with a biopsy-proven diagnosis of GCA were identified among resid
The past 20 years have witnessed a boom in medical education in sub-Saharan Africa,
Neurology in Afrimai mult Journal of Neurology, Neurosurgery & Psychiatry current issue
Sustained disability improvement was observed in about 30% of patients with multiple sclerosis (MS) treated with natalizumab (Tysabri, Biogen Idec, Cambridge, Massachusetts, USA), thus suggesting the occurrence of reversal of neurological dysfunction.
Impulse control disorders (ICD), including pathological gambling, are common in Parkinson's disease (PD) and tend to improve after subthalamic (STN) stimulation after a marked reduction of dopaminergic medication. In order to investigate the effect of STN stimulation on impulsive decision
Holmes tremor, also known as rubral tremor, is defined as the combination of rest, action and postural tremor in the upper extremities with the frequency around 4.5 Hz.
Dementia with Lewy bodies (DLB) is recognised as the second most common form of dementia in older people. Delirium is a condition of acute brain dysfunction for which a pre-existing diagnosis of dementia is a risk factor. Conversely delirium is associated with an increased risk of developing dementimai mult Journal of Neurology, Neurosurgery & Psychiatry current issue
Serial electrophysiology has been suggested as essential for accurate diagnosis in Guillain–Barré syndrome (GBS). However, whether more adapted electrophysiological criteria may allow a single study to be sufficient is unknown.
We retrospectively reviewed records of 365 consecuti
The use of clinical staging in the fatal neurodegenerative disease amyotrophic lateral sclerosis would have value in optimising future therapeutic trials. We aimed to use previous clinical trial data to determine the length of time patients spend in each of four proposed stages, its range
A wide variety of pharmacological agents are used in the management of neuropsychiatric symptoms, which are common in Alzheimer's disease (AD), but results from randomised controlled trials (RCTs) on the efficacy and safety of these agents are conflicting.
To quantify the effi
Staging of disease severity is useful for prognosis, decision-making and resource planning. However, no commonly used, validated staging system exists for amyotrophic lateral sclerosis (ALS). Our purpose was to develop an ALS staging system (ALS Milano-Torino Staging) that captures the ob