Jurnale medicale Psihiatrie
Lymphomatosis cerebri (LC) is a rare variant of primary central nervous system lymphoma (PCNSL) pathologically characterised by diffuse cerebral infiltration of a non-cohesive mass of malignant lymphoid cells. We describe a case of rapidly progressive dementia where MRI demonstrated a d
There is less data available regarding the characteristics of cognitive impairment in patients with amyotrophic lateral sclerosis (ALS) in a population-based series.
Patients with ALS incident in Piemonte, Italy, between 2009 and 2011 underwent an extensive neuropsychological
A 46-year-old woman from Brazil complained about increasing headaches for 2 weeks. On admission, she presented with neck rigidity and disorientation. The cranial MRI was unremarkable (
Since liver transplant (LT) was introduced to treat patients with familial amyloid polyneuropathy carrying the V30M mutation (ATTR-V30M), ocular and cardiac complications have developed. Long-term central nervous system (CNS) involvement was not investigated. Our goals were to: (1) identi
The association between intracranial pressure (ICP) and different shunt valve opening pressures in relation to body positions is fundamental for understanding the physiological function of the shunt.
To analyse the ICP and ICP wave amplitude (AMP) at different shunt settings an
Limited data are available on radiation-induced myopathy (RIM) in adult cancer survivors.
We retrospectively reviewed the clinical, electrophysiological, serological, radiological and pathological findings of patients with RIM seen in the neurology clinic over a 11-year period (2
Alemtuzumab is a newly licensed treatment of active relapsing-remitting multiple sclerosis (RRMS) in Europe, which in phase II and III studies demonstrated superior efficacy over β-interferon in reducing disability progression over 2–3 years. In this observational cohort study, we sought
Reduced deactivation within the default mode network (DMN) is common in individuals with primary affective disorders relative to healthy volunteers (HVs). It is unknown whether similar network abnormalities are present in temporal lobe epilepsy (TLE) patients with a history of affective ps
In 1908, Oluf Bang and Vilhelm Ellerman laid the foundation for theory of oncoviruses by demonstrating that the avian erythroblastosis (a form of chicken leukaemia) could be transmitted by cell-free extracts. Since then, it has been shown very convincingly that viruses can directly cause several hummai mult Journal of Neurology, Neurosurgery & Psychiatry current issue
Recently, several large randomised controlled trials about the treatments of cognitive impairment or dementia due to Parkinson's disease (CIND-PD or PDD) and dementia with Lewy bodies (DLB) were completed. Here, we systematically reviewed the studies (including the recent reports) to provi
Simple, robust, sensitive and clinically meaningful outcome measures are required for neuroprotective trials in Parkinson's disease (PD). We explored the feasibility of a composite binary outcome measure, ‘dead or dependent’, in such trials using data from a prospective follow-up study of
We aimed to examine the association of apolipoprotein E (APOE) 4 genotype with neuroimaging markers of Alzheimer's disease: hippocampal volume, brain amyloid deposition and cerebral metabolism.
We performed a systematic review and meta-analysis of 14 cross-sectional studies identi