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Rheumatology - current issue
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Jurnale medicale Rheumatology - current issue

21 Ianuarie 2015 13:38

Objective. To evaluate left ventricular (LV) function and carotid intima-media thickness (IMT) in patients with axial SpA in relationship to underlying disease severity.

Methods. We recruited 104 patients with axial SpA and 50 controls. Detailed transthoracic echocardiography was performed and analy

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38

Objectives. The 28-joint DAS (DAS28), clinical disease activity index (CDAI) and simplified disease activity index (SDAI) are indices frequently used to assess disease activity in RA patients. Cut-off values were defined to classify the states of RA disease activity: remission, low, moderate and hig

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38
21 Ianuarie 2015 13:38
21 Ianuarie 2015 13:38
21 Ianuarie 2015 13:38

Mesenchymal stem cells (MSCs) are multipotent cells with the capacity to undergo chondrogenic differentiation. Systemically administered MSCs have been shown to preferentially accumulate at sites of tissue damage and inflammation, thus MSC-based therapy holds great promise for the treatment of infla

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38
21 Ianuarie 2015 13:38

SS is a chronic systemic autoimmune disease characterized by decreased exocrine gland function. A variety of other disease manifestations may also be present, including general constitutional symptoms and extraglandular features. A multidisciplinary approach focused on both local and systemic medica

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38

Early differentiation between infection and aseptic inflammation is difficult and is a challenge often faced in the rheumatology practice. Procalcitonin (PCT) is a biomarker that is preferentially induced in patients with bacterial infections, and a growing body of evidence supports its use for impr

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38

Objective. The most widely used classification criteria for SLE are those derived and validated in adult patients by the ACR. Alternatives include the Boston weighted (BW) and SLICC criteria. The aim of this study was to compare the performance of BW and SLICC criteria with the 1997 ACR criteria in

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38

Objective. Pain, the most common manifestation of rheumatological conditions, is highly prevalent among older adults, with worse health outcomes found in those with co-morbid insomnia. Proactive prevention of insomnia may reduce the overall disease burden of pain and rheumatological conditions. To i

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38

Objective. SLE is more prevalent in females, but may cause more severe organ damage in males. The underlying mechanism is incompletely understood. Since macrophage plays a key role in SLE pathogenesis, the present work aimed to investigate whether inflammasomes in male and female SLE macrophages are

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38
21 Ianuarie 2015 13:38

Objective. The aim of this study was to examine the impact of smoking on health-related quality of life (HRQoL) among AS patients who were taking biologic DMARDS.

Methods. This is a longitudinal cohort study of AS patients with anti-TNF treatment in the Australian Rheumatology Association Database (

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38

Objective. We performed a qualitative study to better understand how patients with RA approach risk–benefit trade-offs inherent in the choice of remaining with their current treatment vs escalating care.

Methods. We used a think-aloud protocol to examine how patients with RA approach risk–benefit tr

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38

Objective. The aim of this study was to assess the degree of fluctuation of osteitis on MRI during long-term treatment with etanercept (ETN) in patients with early axial SpA (axSpA) with active inflammation (osteitis) on whole-body MRI in the spine and/or the SI joints at baseline.

Methods. We analy

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38

Objective. To estimate the prevalence of inadequate pain relief (IPR) among patients with symptomatic knee OA prescribed analgesic therapy and to characterize patients with IPR.

Methods. Patients ≥50 years old with physician-diagnosed knee OA who had taken topical or oral pain medication for at leas

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38

Objective. Glucocorticoid injections are used by rheumatologists to treat chronic tendinopathy. Surprisingly, the mechanisms by which corticosteroids induce pain relief in this condition have not been investigated. Previous studies have shown local substance P (SP) levels to be correlated with tendo

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38

Objectives. The aim of the study was to examine the effect of bosentan on blood flow in the hand in a subset of patients who had reduced blood flow relative to healthy subjects. Additionally, the relationship between blood flow in the hands of SSc patients and the presence of digital ulcers (DUs) wa

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38

Objective. The aim of this study was to conduct a cost–utility analysis of the Education, Self-management and Upper Limb Exercise Training in People with RA (EXTRA) programme compared with usual care.

Methods. A within-trial incremental cost–utility analysis was conducted with 108 participants rando

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38

Objective. The aim of this study was to investigate the effect of umbilical cord mesenchymal stem cells (UC-MSCs) on circulating T follicular helper (cTfh) cells in primary SS (pSS) patients.

Methods. The percentage of CXCR5+PD-1+CD4+ T cells in peripheral blood mononuclear cells (PBMCs) was analyse

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38

Objective. The aim of this study was to investigate the pathogenic role of calcium (Ca2+) influx-regulated microRNAs (miRNAs) in T cells from patients with SLE.

Methods. Expression profiles of 270 human miRNAs in Jurkat cells co-cultured with or without ionomycin were analysed by real-time PCR. Diff

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38

Objective. The aim of this study was to identify cold-associated autoantibodies in patients with RP secondary to CTDs.

Methods. Indirect immunofluorescence staining was performed on non-permeabilized cold-stimulated normal human dermal microvascular endothelial cells (dHMVECs), using patients’ sera.

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38

Objective. Granulomatosis with polyangiitis (GPA) is a rare autoimmune systemic vasculitis considered to result from the interaction of environmental factors with a genetically predisposed host. The HLA-DPB1*0401 allele, the PI*Z allele of the gene encoding α1-antitrypsin (SERPINA1) and the proteina

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38

Objective. The autoinflammatory hyperimmunoglobulinaemia D and periodic fever syndrome (HIDS) is characterized by recurrent episodes of fever and inflammation. As part of the mevalonate kinase deficiency spectrum, it is caused by MVK mutations, resulting in decreased mevalonate kinase activity in th

mai mult
Rheumatology - current issue
21 Ianuarie 2015 13:38
21 Ianuarie 2015 13:38
21 Ianuarie 2015 13:38
21 Ianuarie 2015 13:38
21 Ianuarie 2015 13:38
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