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Stroke current issue
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Jurnale medicale Stroke current issue

26 Ianuarie 2015 21:01
Background and Purpose—

Multiple studies have shown that negative computed tomographic angiograms (CTAs) are reliable in excluding aneurysms in patients with isolated perimesencephalic subarachnoid hemorrhage (pSAH). We evaluate the use of digital subtraction angiography versus CTA for initial diagn

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

We examined blood pressure 1 year after stroke discharge and its association with treatment intensification.

Methods—

We examined the systolic blood pressure (SBP) stratified by discharge SBP (≤140, 141–160, or >160 mm Hg) among a national cohort of Veterans discharged after

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

The Combined Approach to Lysis Utilizing Eptifibatide and rt-PA in Acute Ischemic Stroke-Enhanced Regimen (CLEAR-ER) trial demonstrated safety of recombinant tissue-type plasminogen activator (r-tPA) plus eptifibatide in acute ischemic stroke (AIS). CLEAR-ER randomized AIS pa

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
26 Ianuarie 2015 21:01
Background and Purpose—

Fibroblast growth factor 23 (FGF23) is a hormone that regulates phosphorus and vitamin D metabolism. Elevated FGF23 concentrations are associated with excess risk of cardiovascular disease. Associations of FGF23 with stroke outcomes are less clear.

Methods—

Using a case–coho

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

We tested the hypothesis that observationally and genetically elevated YKL-40 is associated with elevated lipids and lipoproteins and with increased risk of ischemic vascular disease.

Methods—

We conducted cohort and Mendelian randomization studies in 96 110 individuals from

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

A better understanding of the stroke risk factors in children with congenital heart disease (CHD) could inform stroke prevention strategies. We analyzed pediatric stroke associated with CHD in a large community-based case–control study.

Methods—

From 2.5 million children (ag

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

White matter hyperintensities (WMH) of presumed vascular origin increase the risk of stroke and dementia. Despite strong WMH heritability, few gene associations have been identified. Relevant experimental models may be informative.

Methods—

We tested the associations between

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

Epidemiological studies suggest that white matter hyperintensities (WMH) are extremely heritable, but the underlying genetic variants are largely unknown. Pathophysiological heterogeneity is known to reduce the power of genome-wide association studies (GWAS). Hypertensive and

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

The mechanisms underlying frontal lobe dysfunction in moyamoya disease (MMD) are unknown. We aimed to determine whether chronic ischemia induces subtle microstructural brain changes in adult MMD and evaluated the association of changes with neuropsychological performance.

Me mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

The characteristics of intracerebral hemorrhage (ICH) may vary by ICH location because of differences in the distribution of underlying cerebral small vessel diseases. Therefore, we investigated the incidence, characteristics, and outcome of lobar and nonlobar ICH.

Methods— mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

Prophylactic anticoagulation for deep venous thrombosis prevention after intracerebral hemorrhage (ICH) is safe. Current guidelines recommend prophylactic anticoagulation after cessation of hematoma growth. We aimed to evaluate nationwide trends in deep venous thrombosis prop

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

We developed and validated a simple algorithm to predict the risk of hematoma growth in acute spontaneous intracerebral hemorrhage (ICH) to better inform clinicians and researchers in their efforts to improve outcomes for patients.

Methods—

We analyzed data from the computed

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

Diffusion MRI is a promising, clinically feasible imaging technique commonly used to describe white matter changes after stroke. We investigated the sensitivity of diffusion MRI to detect microstructural alterations in gray matter after sensorimotor cortex stroke in adult mal

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

Experimental evidence has indicated the benefits of simvastatin for the treatment of subarachnoid hemorrhage. Two randomized placebo-controlled pilot trials that used the highest clinically approved dose of simvastatin (80 mg daily) gave positive results despite the fact that

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

Norrin and its receptor Frizzled-4 have important roles in the blood–brain barrier development. This study is to investigate a potential role and mechanism of Norrin/Frizzled-4 on protecting blood–brain barrier integrity after subarachnoid hemorrhage (SAH).

Methods—

One hund

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

Large longitudinal studies on stroke outcome are scarce. The aim of this study was to analyze predictors and changes in functional outcome during the first year poststroke.

Methods—

Data on patients who were independent in activities of daily living (ADL) and hospitalized fo

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

We previously showed that the microRNA miR-424 protects against permanent cerebral ischemic injury in mice by suppressing microglia activation. This study investigated the role of miR-424 in transient cerebral ischemia in mice with a focus on oxidative stress–induced neuronal

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

Pneumonia is a major cause of mortality and morbidity in patients with stroke fed via nasogastric tubes and may be because of vomiting and gastro-oesophageal regurgitation. The aim of the study was to assess whether regular treatment with metoclopramide, a D2-receptor antagon

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

Following intracerebral hemorrhage (ICH), high-mobility group box 1 protein (HMGB1) may promote neurogenesis that supports functional recovery. How HMGB1 regulates or participates in this process is unclear, as are the pattern recognition receptors and signaling pathways invo

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

Cough protects the lungs from aspiration. We investigated whether respiratory muscle training may improve respiratory muscle and cough function, and potentially reduce pneumonia risk in acute stroke.

Methods—

We conducted a single-blind randomized placebo-controlled trial in

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

17β-estradiol (E2) has been reported to reduce bleeding and brain injury in experimental intracerebral hemorrhage (ICH) model. However, it is not clear if E2 can prevent early hematoma expansion (HE) induced by hyperglycemia in acute ICH. The aim of this study is to evaluate

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

In vivo changes in tissue pH and energy metabolism are key to understanding stroke pathophysiology. Our goal was to study pH changes in subacute ischemic stroke and their relation to energy metabolism, which, unlike acidosis in acute stroke, are not yet well understood.

Meth mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

Variable sex differences in clinical outcomes after stroke have been reported worldwide. This study aimed to elucidate whether sex is an independent risk factor of poor functional outcome after acute ischemic stroke.

Methods—

Using the database of patients with acute stroke

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

The relationships between cerebrovascular lesions visible on imaging and cognition are complex. We explored the possibility that the cerebral cortical volume mediated these relationships.

Methods—

Total of 1906 nondemented participants (59% women; 25% African–American; mean

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

Expression of numerous chemokine-related genes is increased in the brain after ischemic stroke. Here, we tested whether post-stroke administration of a chemokine-binding protein (CBP), derived from the parapoxvirus bovine papular stomatitis virus, might reduce infiltration of

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

White matter hyperintensities (WMH) are associated with clinically heterogeneous symptoms that cannot be explained by these lesions alone. It is hypothesized that these lesions are associated with distant cortical atrophy and cortical thickness network measures, which can res

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

Diabetes mellitus is a disease with vascular components. Consequently, the blood–brain barrier disruption after stroke may differ between diabetic and nondiabetic animals. However, few studies have documented the longitudinal blood–brain barrier disruption afte stroke in diab

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

Diffusion-weighted imaging (DWI) can reliably identify critically ischemic tissue shortly after stroke onset. We tested whether thresholded computed tomographic cerebral blood flow (CT-CBF) and CT-cerebral blood volume (CT-CBV) maps are sufficiently accurate to substitute for

mai mult
Stroke current issue
26 Ianuarie 2015 21:01
Background and Purpose—

Despite the effectiveness of recombinant tissue-type plasminogen activator (r-tPA) during the acute phase of ischemic stroke, the therapy remains limited by a narrow time window and the occurrence of occasional vascular side effects, particularly symptomatic hemorrhages. Our

mai mult
Stroke current issue
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