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Jurnale medicale The Lancet Neurology

26 Octombrie 2014 23:01
????Come on you know who that is, it's you honey?? It is a movie about you ??no kidding [chuckle] I'll be me.? mai mult
The Lancet Neurology
31 Octombrie 2014 00:01
The Science Museum (London, UK) is a playground for the mind. It provokes a childlike curiosity and gets you thinking??an ideal space for parents to visit with their children, and with so much interactive stimuli set in a dynamic learning environment there is little scope for boredom. The exhibitio mai mult
The Lancet Neurology
8 Decembrie 2014 00:01
Multiple system atrophy is a neurodegenerative disorder characterised by autonomic, extrapyramidal, pyramidal, or cerebellar features, or a combination of these features.1,2 At present, no medications are able to slow the relentless disease progression, and treatment of symptoms is inadequate. Thus, mai mult
The Lancet Neurology
8 Decembrie 2014 00:01
In this population of patients with the parkinsonian variant of multiple system atrophy, treatment with rasagiline 1 mg per day did not show a significant benefit as assessed by UMSARS. The study confirms the sensitivity of clinical outcomes for multiple system atrophy to detect clinically significa mai mult
The Lancet Neurology
30 Decembrie 2014 00:01
In boys with Duchenne muscular dystrophy and preserved ejection fraction, addition of eplerenone to background ACEI or ARB therapy attenuates the progressive decline in left ventricular systolic function. Early use of available drugs warrants consideration in this population at high risk of cardiac mai mult
The Lancet Neurology
30 Decembrie 2014 00:01
Duchenne muscular dystrophy is a severe X-linked disease due to loss of dystrophin in skeletal and cardiac muscle. Boys develop progressive weakness and lose the ability to walk by 10 years of age, then develop dilated cardiomyopathy, a leading cause of death. In this context, Subha V Raman and coll mai mult
The Lancet Neurology
5 Ianuarie 2015 00:01
The results of this cross-sectional baseline analysis of the EFACTS cohort suggest that earlier disease onset is associated with larger numbers of GAA repeats and more rapid disease progression. The differential estimated progression of ataxia symptoms related to age of onset have implications for t mai mult
The Lancet Neurology
5 Ianuarie 2015 00:01
Often, the development of therapeutic approaches for rare disease lags behind that of other disorders not because of poor understanding of the basic pathophysiology, but because of a paucity of systematic clinical information. The ideal way to address this scarcity of clinical knowledge and to facil mai mult
The Lancet Neurology
7 Ianuarie 2015 00:01
Our results support a revision of the NeuPSIG recommendations for the pharmacotherapy of neuropathic pain. Inadequate response to drug treatments constitutes a substantial unmet need in patients with neuropathic pain. Modest efficacy, large placebo responses, heterogeneous diagnostic criteria, and p mai mult
The Lancet Neurology
7 Ianuarie 2015 00:01
Neuropathic pain affects 7??8% of people and will become increasingly common because of the ageing population, increasing incidence of diabetes, and improved survival from cancer. Unfortunately, neuropathic pain is undertreated and has a large detrimental effect on quality of life, partly because o mai mult
The Lancet Neurology
31 Ianuarie 2015 22:00
Progressive multiple sclerosis is characterised clinically by the gradual accrual of disability independent of relapses and can occur with disease onset (primary progressive) or can be preceded by a relapsing disease course (secondary progressive). An effective disease-modifying treatment for progre mai mult
The Lancet Neurology
31 Ianuarie 2015 22:00
Nadine Attal is an associate professor of neurology at University Versailles Saint-Quentin, Paris, France. She received her MD from the Piti??-Salp??tri?re Hospital, and her PhD in neurosciences from the Paris VI University, both in Paris. She specialises in neurology and pain, with a focus on neur mai mult
The Lancet Neurology
31 Ianuarie 2015 22:00
A better understanding of the pathological mechanisms that drive neurodegeneration in individuals with multiple sclerosis is needed to develop therapies that will effectively treat patients in the primary and secondary progressive stages of the disease. We propose that the inflammatory demyelinating mai mult
The Lancet Neurology
31 Ianuarie 2015 22:00
A new study shows that intra-arterial treatment given within 6 h after stroke onset can lead to an increase in functional independence in daily life after 3 months, without an increase in mortality, in patients with proximal arterial occlusion in the anterior circulation. The MR CLEAN investigators mai mult
The Lancet Neurology
31 Ianuarie 2015 22:00
Constraint-induced movement therapy (CIMT) was developed to overcome upper limb impairments after stroke and is the most investigated intervention for the rehabilitation of patients. Original CIMT includes constraining of the non-paretic arm and task-oriented training. Modified versions also apply c mai mult
The Lancet Neurology
31 Ianuarie 2015 22:00
We'd perhaps best decide, and quick, because it's here. UK citizens can now have their DNA checked cheaply and quickly for disease-associated mutations. But is that a good thing? Adrian Burton investigates. mai mult
The Lancet Neurology
31 Ianuarie 2015 22:00
Rachel Ventura and colleagues1 have identified a gap in the scientific literature in their recent Review of the neuro-ophthalmology of head trauma. Traumatic brain injury is a challenging area of clinical medicine. The usefulness and promise of neuro-ophthalmological assessment as a screening method mai mult
The Lancet Neurology
31 Ianuarie 2015 22:00
Few neurological disorders have seen so great a transformation in public perception as multiple sclerosis. Over the past 20 years, the disease has moved from being an untreatable disorder with few management options to one with active management underpinned by a wide range of oral and injectable tre mai mult
The Lancet Neurology
31 Ianuarie 2015 22:00
Raman SV, Hor KN, Mazur W, et al. Eplerenone for early cardiomyopathy in Duchenne muscular dystrophy: a randomised, double-blind, placebo-controlled trial. Lancet Neurol 2015; 14: 153??61??In this Article (published online Dec 30, 2014), the second sentence of the Study design and participants section mai mult
The Lancet Neurology
31 Ianuarie 2015 22:00
The past two decades have seen a profound change in the treatment of multiple sclerosis. With recent regulatory approvals, 12 disease-modifying treatments are available in many countries for relapsing-remitting multiple sclerosis (RRMS) and there is a robust pipeline of experimental treatments at va mai mult
The Lancet Neurology
31 Ianuarie 2015 22:00
Studies of the human brain have played a vital part in the advancement of modern neuroscience. Microscopic and histological inventions used by Camillo Golgi, Santiago Ram??n y Cajal, and others to study human brain tissue contributed to the formulation of the reticular theory and neuron doctrine, wh mai mult
The Lancet Neurology
31 Ianuarie 2015 22:00
We thank Michel Belliveau and Davin Johnson for their comments on our Review.1 They note some important features in the diagnosis and management of orbital compartment syndrome. We agree with them that the afferent pupillary defect is an important sign of optic nerve dysfunction in such patients. Li mai mult
The Lancet Neurology
31 Ianuarie 2015 22:00
Disease-modifying drugs have mostly failed as treatments for progressive multiple sclerosis. Management of the disease therefore solely aims to minimise symptoms and, if possible, improve function. The degree to which this approach is based on empirical data derived from studies of progressive disea mai mult
The Lancet Neurology
31 Ianuarie 2015 22:00
The creation of a virtual Center Without Walls to study sudden unexpected death in epilepsy (SUDEP) was announced by the US National Institute of Neurological Disorders and Stroke (NINDS) on Dec 8, 2014. For the epilepsy community??at that time gathered in Seattle, WA, USA, for the Annual Meeting o mai mult
The Lancet Neurology
31 Ianuarie 2015 22:00
Nikolaus Friedreich (1825??1882) was a German neurologist, who is probably best remembered for giving his name to the rare progressive autosomal neurodegenerative disease Friedreich's ataxia, but he was also interested in several other branches of medicine. He was instrumental in the establishment mai mult
The Lancet Neurology
31 Ianuarie 2015 22:00
Hans Lassmann is ??one of the great pioneers of the immunopathology of multiple sclerosis research?, according to Reinhard Hohlfeld of the Institute of Neuroimmunology at LMU Munich, Germany. High praise indeed for someone who combines modesty about his achievements with a good sense of humour an mai mult
The Lancet Neurology
20 Iulie 2014 23:01
Music is deeply personal and can elicit strong emotions. Joy and chills predictably return each time we revisit a favourite melody, hook, or rhythm??it seems as if this response is hard-wired in the brain. Some have also found this musical bliss to completely disappear during a life changing event, mai mult
The Lancet Neurology
21 August 2014 23:01
??Where words fail, music speaks?, a statement that perhaps resonates with us all. We have likely been on the receiving end of a parental wisecrack??if only you could recite your French verbs as well as you can your lyrics to songs??and it is often the case that arranging words or phrases to a mai mult
The Lancet Neurology
14 Noiembrie 2014 00:01
In The Lancet Neurology, the Huntington Study Group Reach2HD Investigators1 report their findings from Reach2HD, a safety and tolerability study of PBT2 in Huntington's disease. PBT2 is a metal-attenuating compound that has already undergone a phase 2 trial in Alzheimer's disease.2 The compound is h mai mult
The Lancet Neurology
14 Noiembrie 2014 00:01
PBT2 was generally safe and well tolerated in patients with Huntington's disease. The potential benefit on executive function will need to be confirmed in a larger study. mai mult
The Lancet Neurology
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