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Jurnale medicale The Lancet Oncology

19 Decembrie 2014 00:01
In MDV3100-11 (NCT01889238), an open-label, two-stage study, Tiffany Traina (New York, NY, USA) and colleagues assessed enzalutamide (160 mg/day) in patients with breast cancer expressing the androgen receptor (??10%), but triple negative for oestrogen receptor, progesterone receptor, and HER2. The mai mult
The Lancet Oncology
19 Decembrie 2014 00:01
The US Food and Drug Administration (FDA) has approved a new version of Merck's cervical cancer vaccine, Gardasil 9, which has the potential to prevent roughly 90% of cervical, vulvar, vaginal, and anal cancers. mai mult
The Lancet Oncology
19 Decembrie 2014 00:01
Adding ovarian suppression to adjuvant tamoxifen does not have a significant effect on disease-free survival for premenopausal women with hormone-receptor-positive breast cancer, according to the primary analysis of the phase 3 SOFT study. The patients had all had prior surgery and were randomly ass mai mult
The Lancet Oncology
31 Decembrie 2014 00:01
The activity and safety profile of single-agent ibrutinib in CLL with TP53 aberrations is encouraging and supports its consideration as a novel treatment option for patients with this high-risk disease in both first-line and second-line settings. mai mult
The Lancet Oncology
31 Decembrie 2014 00:01
Our data indicate that CME surgery is associated with better disease-free survival than is conventional colon cancer resection for patients with stage I??III colon adenocarcinoma. Implementation of CME surgery might improve outcomes for patients with colon cancer. mai mult
The Lancet Oncology
31 Decembrie 2014 00:01
Major improvements in outcomes for rectal cancer have occurred in the 30 years since the introduction of total mesorectal excision and multidisciplinary treatment.1 This situation should continue to improve with more radical surgery for low rectal cancer. Pioneering work by leaders of rectal cancer mai mult
The Lancet Oncology
9 Ianuarie 2015 00:01
Women with HER2-positive metastatic breast cancer who took paclitaxel once weekly with trastuzumab and pertuzumab had comparable progression-free survival to??and lower toxicity than??women in the CLEOPATRA trial, who received docetaxel-based combination therapy, according to a new study. mai mult
The Lancet Oncology
9 Ianuarie 2015 00:01
HPV vaccination is not associated with an increased risk of multiple sclerosis (MS) or other demyelinating diseases, a study of almost 4 million people has confirmed. mai mult
The Lancet Oncology
12 Ianuarie 2015 00:02
Although afatinib did not improve overall survival in the whole population of either trial, overall survival was improved with the drug for patients with del19 EGFR mutations. The absence of an effect in patients with Leu858Arg EGFR mutations suggests that EGFR del19-positive disease might be distin mai mult
The Lancet Oncology
12 Ianuarie 2015 00:02
The frequency and characteristics of EGFR mutations in patients with non-small-cell lung cancer, and their correlation with outcome in patients receiving tyrosine kinase inhibitors, have been previously reported in the scientific literature.1 In The Lancet Oncology, James Chih-Hsin Yang and colleagu mai mult
The Lancet Oncology
12 Ianuarie 2015 00:02
Overall, adjuvant fluorouracil-based chemotherapy did not improve overall survival, disease-free survival, or distant recurrences. However, adjuvant chemotherapy might benefit patients with a tumour 10??15 cm from the anal verge in terms of disease-free survival and distant recurrence. Further stud mai mult
The Lancet Oncology
13 Ianuarie 2015 00:01
Beyond surgery, the optimum treatment for thymic epithelial tumours is unresolved owing to their rarity, histological heterogeneity, and unknown molecular pathogenesis.1,2 The response of thymic epithelial tumours to current chemotherapy agents differs by histological features: advanced stage thymom mai mult
The Lancet Oncology
13 Ianuarie 2015 00:01
Sunitinib is active in previously treated patients with thymic carcinoma. Further studies are needed to identify potential biomarkers of activity. mai mult
The Lancet Oncology
15 Ianuarie 2015 00:01
EGFR expression is detectable in 95% of squamous-cell carcinomas of the head and neck (SCCHN)1 and anti-EGFR antibodies have been investigated in both the palliative-intent and curative-intent therapy settings. Cetuximab is a chimeric mouse IgG1 monoclonal anti-EGFR antibody, and panitumumab is a fu mai mult
The Lancet Oncology
15 Ianuarie 2015 00:01
In patients with locally advanced squamous-cell carcinoma of the head and neck, the addition of panitumumab to standard fractionation radiotherapy and cisplatin did not confer any benefit, and the role of EGFR inhibition in these patients needs to be reassessed. mai mult
The Lancet Oncology
15 Ianuarie 2015 00:01
Panitumumab cannot replace cisplatin in the combined treatment with radiotherapy for unresected stage III??IVb squamous-cell carcinoma of the head and neck, and the role of EGFR inhibition in locally advanced squamous-cell carcinoma of the head and neck needs to be reassessed. mai mult
The Lancet Oncology
16 Ianuarie 2015 00:01
In The Lancet Oncology, Jeffrey Bradley and colleagues1 report a randomised controlled trial of chemoradiotherapy for patients with stage III non-small-cell lung cancer. Patients were randomly assigned to receive high-dose (74 Gy in 37 fractions) or standard dose (60 Gy in 30 fractions) radiotherapy mai mult
The Lancet Oncology
16 Ianuarie 2015 00:01
In this randomised phase 3 trial with a median follow-up of more than 4 years, treatment with abiraterone acetate prolonged overall survival compared with prednisone alone by a margin that was both clinically and statistically significant. These results further support the favourable safety profile mai mult
The Lancet Oncology
16 Ianuarie 2015 00:01
Commercial solariums have been banned across most of Australia from Jan 1, 2015, after a long-running campaign by cancer bodies and patients with melanoma. mai mult
The Lancet Oncology
16 Ianuarie 2015 00:01
Only half of US patients with early-stage Hodgkin's lymphoma (HL) receive combined modality treatment (CMT), according to results from the first analysis of population-based treatment patterns, which also show better survival with CMT than with chemotherapy alone. mai mult
The Lancet Oncology
16 Ianuarie 2015 00:01
Adjuvant paclitaxel and trastuzumab is effective in restricting disease recurrence for patients with low-risk HER2-positive breast cancer, according to new research. The single group study administered the therapy prospectively to 406 patients with small, node-negative, HER2-positive tumours. Treatm mai mult
The Lancet Oncology
16 Ianuarie 2015 00:01
74 Gy radiation given in 2 Gy fractions with concurrent chemotherapy was not better than 60 Gy plus concurrent chemotherapy for patients with stage III non-small-cell lung cancer, and might be potentially harmful. Addition of cetuximab to concurrent chemoradiation and consolidation treatment provide mai mult
The Lancet Oncology
16 Ianuarie 2015 00:01
A combination of two vaccines, the Cy/GVAX pancreas tumour vaccine and the immunostimulant CRS-207 significantly improved overall survival in patients with previously treated, metastatic pancreatic ductal adenocarcinoma (PDA), according to results from the first randomised study to show an improveme mai mult
The Lancet Oncology
16 Ianuarie 2015 00:01
In The Lancet Oncology, Charles Ryan and colleagues report the final analysis of overall survival from COU-AA-302, a randomised phase 3 trial of abiraterone and prednisone versus placebo plus prednisone in chemotherapy-naive patients with metastatic, castration-resistant prostate cancer.1 Although i mai mult
The Lancet Oncology
31 Ianuarie 2015 22:00
Familial gastric cancer comprises at least three major syndromes: hereditary diffuse gastric cancer, gastric adenocarcinoma and proximal polyposis of the stomach, and familial intestinal gastric cancer. The risk of development of gastric cancer is high in families affected b-y these syndromes, but o mai mult
The Lancet Oncology
31 Ianuarie 2015 22:00
The benefits of adjuvant radiotherapy in positive axillary nodal regions after breast-conserving and postmastectomy surgery have been recently demonstrated.1,2 Even though sentinel lymph node biopsy has largely replaced lymphadenectomy in the assessment of micrometastases in sentinel lymph nodes, it mai mult
The Lancet Oncology
31 Ianuarie 2015 22:00
We appreciate Lorenzo Livi, Icro Meattini, and Paolo Farace and colleagues' comments on our AMAROS study1 which examined whether axillary radiation therapy can replace axillary lymph node dissection (ALND) and whether axillary structures could be better spared using axillary radiotherapy. mai mult
The Lancet Oncology
31 Ianuarie 2015 22:00
Palliative care??defined by WHO as ??an approach that improves the quality of life of patients and their families facing the problems associated with life-threatening illness, through the prevention and relief of suffering?1??has been largely absent from the global health dialogue and consequen mai mult
The Lancet Oncology
31 Ianuarie 2015 22:00
In January, 2015, the UK National Health Service (NHS) reported a record number of patients using accident and emergency (A&E) departments, which led to several hospitals declaring ??major incident? status. This status meant cancelling outpatient services and non-essential surgeries (including ca mai mult
The Lancet Oncology
31 Ianuarie 2015 22:00
What Men Won't Talk About??and Women Need to Know: A Woman's Perspective on Prostate Cancer by Glenda Standeven is a practical book, designed with a specific purpose??to help women whose husbands have prostate cancer. The slim book is written in an engaging, conversational style as if Standeven is mai mult
The Lancet Oncology
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