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The Lancet
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Jurnale medicale The Lancet

12 Octombrie 2014 23:01
CD19-CAR T cell therapy is feasible, safe, and mediates potent anti-leukaemic activity in children and young adults with chemotherapy-resistant B-precursor acute lymphoblastic leukaemia. All toxicities were reversible and prolonged B-cell aplasia did not occur. mai mult
The Lancet
12 Octombrie 2014 23:01
In The Lancet, Daniel Lee and colleagues1 report on a novel approach for the treatment of childhood acute lymphoblastic leukaemia, with important implications for other cancers. B-lineage acute lymphoblastic leukaemia is the commonest childhood cancer, with some 400 new cases a year in the UK. Despi mai mult
The Lancet
13 Octombrie 2014 23:01
Long-term functional outcome and risk of fatal or disabling stroke are similar for stenting and endarterectomy for symptomatic carotid stenosis. mai mult
The Lancet
13 Octombrie 2014 23:01
In The Lancet, Leo Bonati and colleagues1 describe the results of the International Carotid Stenting Study (ICSS), a randomised controlled trial comparing carotid artery stenting and carotid endarterectomy. I compliment the authors for completing the largest trial of these two revascularisation stra mai mult
The Lancet
15 Octombrie 2014 15:42
In The Lancet, Steven Schwartz and colleagues1 report the mid-term and long-term outcomes of the use of human embryonic stem-cell (hESC)-derived retinal pigment epithelial cells for the treatment of dry atrophic age-related macular degeneration and Stargardt's macular dystrophy, the leading causes o mai mult
The Lancet
15 Octombrie 2014 15:42
The results of this study provide the first evidence of the medium-term to long-term safety, graft survival, and possible biological activity of pluripotent stem cell progeny in individuals with any disease. Our results suggest that hESC-derived cells could provide a potentially safe new source of c mai mult
The Lancet
28 Octombrie 2014 00:01
A 10-year-old boy, 144 cm tall, was referred to our hospital in October, 2012, with a 2 month history of persistent pain in the buttocks. He had altered gait due to pain, but no disturbance of bladder or bowels. Radiographs, CT, and MRI showed a large osteolytic lesion in the sacrum, and examination mai mult
The Lancet
6 Noiembrie 2014 00:01
In high-income countries, life expectancy at age 60 years has increased in recent decades. Falling tobacco use (for men only) and cardiovascular disease mortality (for both men and women) are the main factors contributing to this rise. In high-income countries, avoidable male mortality has fallen si mai mult
The Lancet
6 Noiembrie 2014 00:01
The ageing of populations is poised to become the next global public health challenge. During the next 5 years, for the first time in history, people aged 65 years and older in the world will outnumber children aged younger than 5 years.1 Advances in medicine and socioeconomic development have subst mai mult
The Lancet
6 Noiembrie 2014 00:01
Ageing, says Richard Suzman, is ??reshaping our world?. Like climate change, ??it seems inexorable, and is gradual?, he says; but the global impact of ageing on health, disability, wellbeing, and poverty might eventually turn out almost as profound for society as rising temperatures. As Direct mai mult
The Lancet
6 Noiembrie 2014 00:01
Recently, a medical student entered an operating room in a tertiary care medical centre affiliated with a leading American medical school. The room had pale walls, bright lights, lots of chrome, and a gurney on which lay a large, unconscious man, his abdomen open. A surgeon greeted the student enthu mai mult
The Lancet
6 Noiembrie 2014 00:01
Ageing is a dynamic process, and trends in the health status of older adults aged at least 60 years vary over time because of several factors. We examined reported trends in morbidity and mortality in older adults during the past two decades to identify patterns of ageing across the world. We showed mai mult
The Lancet
6 Noiembrie 2014 00:01
23% of the total global burden of disease is attributable to disorders in people aged 60 years and older. Although the proportion of the burden arising from older people (??60 years) is highest in high-income regions, disability-adjusted life years (DALYs) per head are 40% higher in low-income and mai mult
The Lancet
26 Ianuarie 2015 00:01
The news headlines are filled with mentions of infectious diseases??eg, Ebola, influenza, malaria, and tuberculosis, but the reality is that the global burden of disease is shifting from infectious diseases to non-communicable diseases (NCDs).1 A 2014 report by WHO2 about NCDs in 194 countries stat mai mult
The Lancet
6 Februarie 2015 22:00
More than 60 years ago, Virginia Apgar proposed a score to describe the postnatal condition of every newborn.1 mai mult
The Lancet
6 Februarie 2015 22:00
With interest, we read Dominic Stoop and colleagues' Series paper on fertility preservation (Oct 4, p 1311).1 Fertility preservation is likely to expand in the next 5 years, for both risk of premature ovarian failure and social reasons.1??6 Cryopreservation of ovarian tissue is now gaining ground a mai mult
The Lancet
6 Februarie 2015 22:00
We thank Jacques Donnez and colleagues, and Ben Mol and Miriam Zoll for their interest in our report.1 We share the opinion expressed by Donnez and colleagues about the absence of an accurate account of the number of re-implantations in reported studies. For this reason, tables 2 and 3 of our report mai mult
The Lancet
6 Februarie 2015 22:00
Chatterji S, Byles J, Cutler D, et al. Health, functioning, and disability in older adults??present status and future implications. Lancet 2015; 385: 563??75??In this Series paper, the affiliation for Professor Byles has been corrected: Research Centre for Gender Health and Ageing, University of Newc mai mult
The Lancet
6 Februarie 2015 22:00
We acknowledge the concerns of Caren Lanting and Jacobus van Wouwe; the mothers' age of 10 years was an a priori threshold established before the analysis on the basis of biological plausibility that there might be no records of births by mothers younger than this age. mai mult
The Lancet
6 Februarie 2015 22:00
Pioneer of Chinese nephrology. She was born in Qingdao, China, on July 8, 1937, and died from a heart attack in Beijing, China, on Dec 11, 2014, aged 77 years. mai mult
The Lancet
6 Februarie 2015 22:00
Dominic Stoop and colleagues1 discussed the application of fertility preservation techniques to counter natural age-related fertility decline. We are concerned about some factual rates presented by the authors. Most importantly, the authors fail to mention that natural conception rates in women olde mai mult
The Lancet
6 Februarie 2015 22:00
As part of the Lancet fertility preservation Series, Michel De Vos and colleagues (Oct 4, p 1302)1 presented a concise overview of fertility preservation methods for women with cancer. Here, we aim to emphasise that contraception counselling is just as important. mai mult
The Lancet
6 Februarie 2015 22:00
Although studies that ascribe future health of infants as a function of Apgar scores at birth often examine the Apgar score at 5 min,1 little physiological evidence exists for its use. About 5??10% of newborns need ventilatory assistance, and less than 1% need extensive resuscitation.2 These measur mai mult
The Lancet
6 Februarie 2015 22:00
Last week, Human Rights Watch (HRW) released World Report 2015, their 25th annual global review documenting human rights practices in more than 90 countries and territories in 2014. The content is based on a comprehensive investigation by HRW staff, together with in-country human rights activists. I mai mult
The Lancet
6 Februarie 2015 22:00
In 1828 John Martin??painter of vigorously cinematic Biblical apocalypses??drew up an elegant and apparently practical plan for modernising London's antiquated system of water supply, and presented it to a parliamentary commission. Over the next 8 years his scheme was repeatedly rejected, partly o mai mult
The Lancet
6 Februarie 2015 22:00
Health services in east Ukraine are running out of essential medicines and facing serious shortages of doctors as fighting continues between the army and pro-Russian separatists. Ed Holt reports. mai mult
The Lancet
6 Februarie 2015 22:00
The director of No Control, Jessica Solce, aimed to ??create an open framework for debate?, on the role of guns in the USA. This is no small feat, given the entrenched ideological positions that this topic provokes between Americans who see guns as a constitutional and cultural right, and those w mai mult
The Lancet
6 Februarie 2015 22:00
Donors responded overwhelmingly at the recent GAVI replenishment meeting, pledging slightly more than the US$7?5 billion fundraising target for 2016??20. Ann Danaiya Usher reports. mai mult
The Lancet
6 Februarie 2015 22:00
Despite evidence that overcrowded, poorly maintained housing is leading to health problems in Canada's Indigenous communities, the government has yet to act. Paul C Webster reports. mai mult
The Lancet
6 Februarie 2015 22:00
As patient groups and hepatologists we applaud and support the work of the Lancet Commission1 in drawing attention to the growing problem of chronic liver disease in the UK. However, we are concerned that the focus was only on lifestyle-related liver disease.1 We do not doubt of the importance of al mai mult
The Lancet
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