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The Oncologist current issue
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Diabetes Care Journal current issue Diabetes Journal current issue Diabetes Spectrum Journal current issue
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Jurnale medicale The Oncologist current issue

6 Februarie 2015 15:59
6 Februarie 2015 15:59
Background.

Limited data are available regarding outcomes in elderly head and neck cancer patients. This retrospective study was designed to characterize head and neck cancer in geriatric patients.

Patients and Methods.

This study included all patients in a large university-based tumor registry who

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The Oncologist current issue
6 Februarie 2015 15:59
6 Februarie 2015 15:59
Background.

Treatment of borderline ovarian tumors (BOTs) remains contentious, and there is no consensus regarding therapy for BOTs with invasive implants (BOTi). The benefits of platinum-based adjuvant treatment were evaluated in patients with BOTi at primary diagnosis.

Methods.

The PubMed databas

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The Oncologist current issue
6 Februarie 2015 15:59
6 Februarie 2015 15:59
Background.

nab-Paclitaxel in combination with gemcitabine has emerged as a new treatment option for patients with metastatic pancreatic cancer (MPC), based on superiority over gemcitabine demonstrated in the phase III MPACT trial. Previously, Karnofsky performance status (KPS) score and the presenc

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The Oncologist current issue
6 Februarie 2015 15:59
Background.

Cancer pain is usually managed by oncologists, occasionally with input from specialists in hospice and palliative medicine (PLM) or pain medicine (PMD). We evaluated the knowledge of cancer pain management in these three specialty groups.

Methods.

Eight vignettes depicting challenging s

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The Oncologist current issue
6 Februarie 2015 15:59

Over the last several decades, the incidence of adenocarcinoma of the gastroesophageal junction (GEJ) has been increasing in developed countries. Although complete surgical resection remains the cornerstone of treatment for resectable disease, long-term outcomes are poor and recurrence rates are hig

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The Oncologist current issue
6 Februarie 2015 15:59

Cancer is the leading disease-related cause of death in adolescents and young adults (AYAs). This population faces many short- and long-term health and psychosocial consequences of cancer diagnosis and treatment, but many programs for cancer treatment, survivorship care, and psychosocial support do

mai mult
The Oncologist current issue
6 Februarie 2015 15:59
Background.

Approximately 20% of patients with stage II colorectal cancer will experience a relapse. Current clinical-pathologic stratification factors do not allow clear identification of these high-risk patients. ColoPrint (Agendia, Amsterdam, The Netherlands, http://www.agendia.com) is a gene exp

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The Oncologist current issue
6 Februarie 2015 15:59

Bevacizumab, currently an option for treatment of different types of tumors including glioblastoma, has a peculiar toxicity profile related to its antiangiogenic effect. Because some bevacizumab-related adverse events can be life threatening, it is important to identify risk factors and to establish

mai mult
The Oncologist current issue
6 Februarie 2015 15:59
Background.

The treatment of differentiated thyroid cancer refractory to radioactive iodine (RAI) had been hampered by few effective therapies. Recently, tyrosine kinase inhibitors (TKIs) have shown activity in this disease. Clinical guidance on the use of these agents in RAI-refractory thyroid canc

mai mult
The Oncologist current issue
6 Februarie 2015 15:59
6 Februarie 2015 15:59
Background.

The approved capecitabine regimen as monotherapy in metastatic breast cancer (MBC) is 1,250 mg/m2 twice daily for 2 weeks on and 1 week off (Cint). Dose modifications are often required because of severe hand-foot syndrome (HFS). We tested a continuous regimen with a lower daily dose but

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The Oncologist current issue
6 Februarie 2015 15:59
Background.

Many cancer patients receive supplemental ascorbate (vitamin C) in the belief that it synergizes the anticancer effects of chemotherapy and reduces its toxicity.

Methods.

A systematic review was performed to evaluate the antitumor effects and toxicity of ascorbate treatment. Medline (19

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The Oncologist current issue
6 Februarie 2015 15:59
Background.

Anthracyclines and taxanes are effective drugs in breast cancer (BC), but their toxicity profiles limit their use in combination. A dose-finding study was performed to determine maximum tolerated doses (MTDs) of nonpegylated liposomal doxorubicin (TLC-D99) and docetaxel (DTX) as a dose-d

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The Oncologist current issue
6 Februarie 2015 15:59

Immunotoxins are a novel class of antibody-conjugated therapeutics currently in clinical development for a variety of malignancies. They consist of an antibody-based targeting domain fused to a bacterial toxin payload for cell killing. Immunotoxins kill cells by inhibiting protein synthesis, a uniqu

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The Oncologist current issue
6 Februarie 2015 15:59
Background.

Patients with a newly diagnosed glioblastoma multiforme (GBM) have a high risk of recurrent disease with a dismal outcome despite intensive treatment of sequential surgery and chemoradiotherapy with temozolomide (TMZ), followed by TMZ as a single agent. Bevacizumab (BV) may increase resp

mai mult
The Oncologist current issue
6 Februarie 2015 15:59
6 Februarie 2015 15:59
Background.

Platinum plus etoposide is the standard therapy for extensive-stage small cell lung cancer (ES-SCLC) and is associated with significant myelosuppression. We hypothesized that the combination of carboplatin and nanoparticle albumin-bound paclitaxel (nab-paclitaxel) would be better tolerat

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The Oncologist current issue
6 Februarie 2015 15:59
6 Februarie 2015 15:59

This review considers the potential utility of positron emission tomography (PET) tracers in the setting of response monitoring in breast cancer, with a special emphasis on glucose metabolic changes assessed with 18F-fluorodeoxyglucose (FDG). In the neoadjuvant setting of breast cancer, the metaboli

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The Oncologist current issue
6 Februarie 2015 15:59

Axitinib is a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 1 (VEGFR-1), VEGFR-2, and VEGFR-3. Based on the positive opinion from the European Medicines Agency (EMA), a marketing authorization valid throughout the European Union (EU) was issued for the treatment of advance

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The Oncologist current issue
14 Ianuarie 2015 18:14
14 Ianuarie 2015 18:14
Purpose.

This study evaluated age-related changes in pharmacokinetic and pharmacodynamic parameters of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) in patients with metastatic breast cancer.

Methods.

Forty patients received nab-paclitaxel (100 mg/m2 weekly for 3 weeks followed by a 1-week

mai mult
The Oncologist current issue
14 Ianuarie 2015 18:14
14 Ianuarie 2015 18:14
Background.

We compared the public perception of cancer care in Poland and Austria. Both countries are members of the European Union (EU) but reflect two extremes in health-related per capita spending. Recently, the EUROCARE-5 study reported on very discrepant cancer outcomes between the two countri

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The Oncologist current issue
14 Ianuarie 2015 18:14
Background.

Both the American Society of Clinical Oncology and the European Society for Medical Oncology strongly endorse integrating oncology and palliative care (PC); however, a global consensus on what constitutes integration is currently lacking. To better understand what integration entails, we

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The Oncologist current issue
14 Ianuarie 2015 18:14

Thyroid nodules are commonly diagnosed in adults. Although rare in children, the risk for thyroid cancer is much higher in the pediatric population compared with adults. Presenting as either a solitary nodule or a multinodular goiter, thyroid nodular disease in children requires a thorough workup th

mai mult
The Oncologist current issue
14 Ianuarie 2015 18:14
Background.

Health-related quality of life (QoL) has been validated as a prognostic factor for cancer patients; however, to be used in routine practice, QoL scores must be dichotomized. Cutoff points are usually based on arbitrary percentile values. We aimed to identify optimal cutoff points for six

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The Oncologist current issue
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